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    Process for the separation of virus from non-viral proteins
    1.
    发明授权
    Process for the separation of virus from non-viral proteins 失效
    从非病毒蛋白分离病毒的过程

    公开(公告)号：US3655509A

    公开(公告)日：1972-04-11

    申请号：US3655509D

    申请日：1969-05-29

    Applicant: MONSANTO CO

    Inventor： FIELDS JOSEPH E ,  JOHNSON JOHN H

    IPC: C12N7/02 ,  C12K7/00

    CPC classification number: C12N7/00 ,  C12N2710/16051 ,  C12N2770/32651 ,  Y10S530/826

    Abstract: Viruses are selectively separated from an aqueous mixture of virus and nonviral protein by contacting the aqueous mixture with a water-insoluble polyelectrolyte polymer containing basic groups to selectively sorb the virus on the polymer and then if desired removing the polymer containing the virus from the aqueous mixture. The polyelectrolyte polymers are polycationic or polyampholytic in nature and contain imide groups selected from the group consisting of diloweralkylaminoloweralkylimide groupings and loweralkyliminodi(loweralkylimide) linkages as exemplified by crosslinked dimethylaminopropylimide derivatives of isobutylene/maleic anhydride copolymers.

    Abstract translation: 通过使含水混合物与含有碱性基团的水不溶性聚电解质聚合物接触，将病毒和非病毒蛋白质的水性混合物选择性地分离，以选择性地吸附聚合物上的病毒，然后如果需要，从含水混合物中除去含有病毒的聚合物 。 聚电解质聚合物本质上是阳离子或聚阴离子的，并且含有选自二异丁烯基氨基低级烷基亚胺基和低级烷基亚氨基（低级烷基亚胺）键的酰亚胺基，如异丁烯/马来酸酐共聚物的交联二甲基氨基丙基酰亚胺衍生物所示例。

    Cross-linked copolymer polyelectrolytes based on alpha,beta-ethylenically unsaturated acids
    4.
    发明授权
    Cross-linked copolymer polyelectrolytes based on alpha,beta-ethylenically unsaturated acids 失效
    基于ALPHA，亚乙基不饱和酸的交联共聚物聚电解质

    公开(公告)号：US3554985A

    公开(公告)日：1971-01-12

    申请号：US3554985D

    申请日：1969-12-15

    Applicant: MONSANTO CO

    Inventor： FIELDS JOSEPH E ,  JOHNSON JOHN H

    IPC: B01J20/22 ,  C02F1/28 ,  C02F1/50 ,  C08F8/00 ,  C08F22/04 ,  C08F27/08

    CPC classification number: C08F22/04 ,  B01J20/22 ,  C02F1/28 ,  C02F1/285 ,  C02F1/50 ,  C08F8/00 ,  C08F20/02

    Abstract: WATER-INSOLUBLE, CROSS-LINKED POLYELECTROLYTE COPOLYMERS OF (A) AN UNSATURATED MONOMER OF 2 TO 12 CARBON ATOMS AND (B) A MONOMER SELECTED FROM THE GROUP CONSISTING OF (1) A MIXTURE OF AN UNSATURATED POLYCARBOXYLIC ACID OR ANHYDRIDE AND AN UNSATURATED POLYCARBOXYLIC ACID AMINE-IMIDE, AND (2) AN UNSATURATED POLYCARBOXYLIC ACID AMINE-IMIDE, THE POLYMERIC UNITS OF THE POLYELECTROLYTE CONTAINING AT LEAST THREE PERCENT OF AN AMINE-IMIDE GROUP, WHICH GROUP IS A DILOWERALKYLAMINOLOWERALKYLIMIDE GROUP WHEREIN LOWER ALKY HAS 1 TO 5 CARBON ATOMS INCLUSIVE, INCLUDING ACID ADDITION AND QUATERNARY AMMONIUM SALTS THEREOF, THE POLYELECTROLYTE HAVING A MOLECULAR WEIGHT OF AT LEAST 1000. THE POLYELECTROLYTES ARE USED FOR PURIFYING WATER CONTAMINATED WITH VIRUSES, COLIFORM BACTERIA, OTHER MICROORGANISMS OR SURFACE ACTIVE AGENTS BY ADSORPTION.

    Method of lowering blood cholesterol level
    8.
    发明授权
    Method of lowering blood cholesterol level 失效
    降低血液胆固醇水平的方法

    公开(公告)号：US3923972A

    公开(公告)日：1975-12-02

    申请号：US35383273

    申请日：1973-04-23

    Applicant: MONSANTO CO

    Inventor： FIELDS JOSEPH E ,  JOHNSON JOHN H

    IPC: A61K31/74 ,  A61K27/00

    CPC classification number: A61K31/74

    Abstract: The level of blood cholesterol in a living animal body in which a state of hypercholesterolemia exists is lowered by orally administering to said animal body a pharmaceutically effective amount of a polymer, which is (1) polymerized unsaturated carboxylic acid or anhydride, or (2) a copolymer of (a) an unsaturated monomer having, for Example, 2 to 30 carbon atoms and, (b) an unsaturated carboxylic acid, anhydride or derivative thereof as exemplified by octadecene-1/maleic anhydride copolymer. Polymers having lipophilic properties are a preferred class. A typical dosage is an amount which represents in the range of from about 0.01 to about 5.0% of the diet.

    Abstract translation: 或（2）通过向所述动物体内口服给药药物有效量的聚合物来降低存在高胆固醇血症状态的活体动物体内的血液胆固醇水平，所述聚合物为（1）聚合的不饱和羧酸或酸酐，或（2） （a）具有例如2至30个碳原子的不饱和单体和（b）不饱和羧酸，酸酐或其衍生物的共聚物，例如由十八碳烯-1-马来酸酐共聚物示例。 具有亲油性的聚合物是优选的类别。 典型的剂量是代表饮食约0.01至约5.0％范围内的量。

    Treatment of diarrhea employing certain basic polyelectrolyte polymers
    9.
    发明授权
    Treatment of diarrhea employing certain basic polyelectrolyte polymers 失效
    使用某些基本的聚电解质聚合物处理糖尿病

    公开(公告)号：US3655869A

    公开(公告)日：1972-04-11

    申请号：US3655869D

    申请日：1969-01-02

    Applicant: MONSANTO CO

    Inventor： WHARTON FERDINAND D ,  JOHNSON JOHN H ,  FIELDS JOSEPH E ,  MACHLIN LAWRENCE J

    IPC: A61K31/785 ,  A61K27/00

    CPC classification number: A61K31/785

    Abstract: THE TREATMENT OR PREVENTION OF GASTRO-ENTERITIS DIARRHEAL SYNDROME (IDARRHEA) IN A LIVING ANIMAL BODY IS ACCOMPLISHED BY ORALY ADMINISTERING TO SAID ANIMAL BODY A THERAPEUTICALLY EFFECTIVE AMOUNT OF A BASIC POLYELECTROLYTE POLYMER, WHICH IS (A) A POLYMERIZED UNSATURATED CARBOXYLIC ACID OR ANHYDRIDE AND A DERIVATIVE OF A POLYMERIZED UNSATURATED CARBOXYLIC ACID OR ANHYDRIDE, (B) A DERIVATIVE OF A POLYMERIZED UNSATURATED CARBOXYLIC ACID OR ANHYDRIDE OR (C) A COPOLYMER OF (1) AN UNSATURATED MONOMER HAVING 2 TO 18 CARBON ATOMS AND (2) A MONOMER SELECTED FROM THE GROUP CONSISTING OF (A) AN UNSATURATED CARBOXYLIC ACID OR ANHYDRIDE AND A DERIVATIVE OF AN UNSATURATED CARBOXYLIC ACID OR NHYDRIDE AND (B) A DERIVATIVE OF AN UNSATURATED CARBOXYLIC ACID OR ANHYDRIDE, AS EXEMPLIFIED BY N,N-DIMETHYLAMINOPROPYLIMIDE OF ETHYLENE/MALEIC ANHYDRIDE COPOLYMER. THE BASIC POLYMER IS POLYCATIONIC OR POLYAMPHOLYTIC IN NATURE. TYPICAL DOSAGE IS 0.05 TO 5.0% OF THE TOTAL DIET.

    Apparatus and process for making continuous filament
    10.
    发明授权
    Apparatus and process for making continuous filament 失效
    制造连续薄膜的装置和工艺

    公开(公告)号：US3626041A

    公开(公告)日：1971-12-07

    申请号：US3626041D

    申请日：1968-11-13

    Applicant: MONSANTO CO

    Inventor： FIELDS JOSEPH E ,  MOTTUS EDWARD H

    IPC: B29C70/10 ,  B29C70/14 ,  B29C70/40 ,  B29H1/02 ,  B01D13/02 ,  B06B1/02

    CPC classification number: B29C70/40 ,  B29C70/10 ,  B29C70/14 ,  Y10T428/2967

    Abstract: A process for making a continuous filament from discrete particulate matter including particles and fibers and mixtures thereof which may be initially packed and oriented in any random fashion. The particulate matter is added to a reaction vessel having a pair of electrodes therein. A strong electrokinetic field is established in this vessel and this electrokinetic field will untangle and properly orient the various random fibers and particulate matter through its influence. This action will cause close packing of the particulate matter in a desired pattern. Furthermore, the orientation is made to take place in a polymeric composition or resin matrix system so that the particulate matter is not only oriented, but held in the oriented position without the aid of the electrokinetic field. During the process of alignment and polymerization or partial polymerization, the continuous filament is formed and simultaneously removed outwardly from the vessel and then fully cured.

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