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    Nucleic acid encoding anti-GM-CSF antibodies
    3.
    发明授权
    Nucleic acid encoding anti-GM-CSF antibodies 有权

    公开(公告)号：US11028165B2

    公开(公告)日：2021-06-08

    申请号：US16442779

    申请日：2019-06-17

    Applicant: MORPHOSYS AG

    Inventor： Stefan Steidl ,  Elisabeth Thomassen-Wolf

    IPC: C12N15/63 ,  C12N15/64 ,  C07K16/24 ,  A61K39/00

    Abstract: The present invention provides recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific for GM-CSF, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, inflammatory diseases such as rheumatoid arthritis. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of GM-CSF in the progression of various disorders. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

    ANTI-GM-CSF ANTIBODIES
    4.
    发明申请
    ANTI-GM-CSF ANTIBODIES 审中-公开

    公开(公告)号：US20200024340A1

    公开(公告)日：2020-01-23

    申请号：US16442779

    申请日：2019-06-17

    Applicant: MORPHOSYS AG

    Inventor： Stefan Steidl ,  Elisabeth THOMASSEN-WOLF

    IPC: C07K16/24

    Abstract: The present invention provides recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific for GM-CSF, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, inflammatory diseases such as rheumatoid arthritis. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of GM-CSF in the progression of various disorders. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

    Methods of treatment using anti-GM-CSF antibodies
    7.
    发明授权
    Methods of treatment using anti-GM-CSF antibodies 有权

    公开(公告)号：US10377820B2

    公开(公告)日：2019-08-13

    申请号：US15386152

    申请日：2016-12-21

    Applicant: MORPHOSYS AG

    Inventor： Stefan Steidl ,  Elisabeth Thomassen-Wolf

    IPC: A61K39/395 ,  C07K16/24 ,  A61K39/00

    Abstract: The present invention provides recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific for GM-CSF, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, inflammatory diseases such as rheumatoid arthritis. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of GM-CSF in the progression of various disorders. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

    Use of c-Fms antagonists
    9.
    发明申请
    Use of c-Fms antagonists 有权
    使用c-Fms拮抗剂

    公开(公告)号：US20160185867A1

    公开(公告)日：2016-06-30

    申请号：US14970578

    申请日：2015-12-16

    Applicant: MorphoSys AG ,  The University of Melbourne

    Inventor： Stefan Steidl ,  John Allan Hamilton ,  Andrew David Cook

    IPC: C07K16/28 ,  C07K16/24

    CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K16/243 ,  C07K16/244 ,  C07K16/249 ,  C07K2317/76

    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.

    Abstract translation: 本发明一般涉及治疗和/或预防骨关节炎（OA）和/或疼痛的方法。 根据本发明，c-Fms的拮抗剂对于治疗骨关节炎和/或疼痛是有效的。 M-CSF的拮抗剂包括但不限于对M-CSF，IL-34或c-Fms特异性的抗体。

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