公开(公告)号：US20250065131A1

公开(公告)日：2025-02-27

申请号：US18949065

申请日：2024-11-15

Applicant: Synchron Australia Pty Limited ,  The University of Melbourne

Inventor： Nicholas Lachlan OPIE ,  Thomas James OXLEY ,  Gil Simon RIND

IPC: A61N1/36 ,  A61N1/375 ,  A61N1/378

Abstract: Systems, apparatus, and methods for treating medication refractory epilepsy are disclosed. In one embodiment, a method of treating epilepsy is disclosed comprising detecting, using a first electrode array coupled to a first endovascular carrier, an electrophysiological signal of a subject. The method further comprises analyzing the electrophysiological signal using a neuromodulation unit electrically coupled to the first electrode array and stimulating an intracorporeal target of the subject using a second electrode array coupled to a second endovascular carrier implanted within a part of a bodily vessel superior to a base of the skull of the subject.

公开(公告)号：US20250054298A1

公开(公告)日：2025-02-13

申请号：US18719543

申请日：2022-12-14

Applicant: Rubicon Research Pty Ltd ,  The University of Melbourne

Inventor： Zitian Gao ,  Danlu Guo ,  Andrew William Western ,  Dongryeol Ryu ,  David John Aughton

IPC: G06V20/10 ,  G06T3/40 ,  G06T7/13 ,  G06V10/762 ,  G06V10/764

Abstract: An automated method of classifying irrigation status of fields within a geographical region includes identifying a plurality of field areas delineated by field boundaries within the geographical region. Seasonal normalised difference vegetation index (NDVI) time series data are processed to generate a plurality of aggregate field NDVI feature values for each identified field area. Irrigation status of each identified field area is classified by executing a decision tree classifier that is configured to determine a classification as either ‘irrigated’ or ‘non-irrigated’ based upon the corresponding plurality of aggregate field NDVI feature values.

公开(公告)号：US20250026793A1

公开(公告)日：2025-01-23

申请号：US18703126

申请日：2022-10-21

Applicant: THE UNIVERSITY OF MELBOURNE

Inventor： Adam Kenneth WHEATLEY ,  Hyon Xhi TAN ,  Jennifer Ann JUNO ,  Stephen John KENT

IPC: C07K14/005 ,  A61K39/215 ,  A61P31/14

Abstract: The present invention relates to chimeric coronavirus spike polypeptides and uses thereof, including in vaccines.

公开(公告)号：US20250009917A1

公开(公告)日：2025-01-09

申请号：US18696307

申请日：2022-09-29

Applicant: THE UNIVERSITY OF MELBOURNE ,  OLIVIA NEWTON-JOHN CANCER RESEARCH INSTITUTE

Inventor： Katherine Anne Morgan ,  Paul Stephen Donnelly ,  Christian Werner Wichmann ,  Andrew Mark Scott

IPC: A61K51/10 ,  A61K51/04 ,  A61P35/00 ,  C07B59/00

Abstract: The present invention relates to compounds of formula (I) that have the ability to be used as metal complexes in radiotherapy. wherein A is selected from the group consisting of CO2R1, and PO3R1; B is selected from the group consisting of CO2R2, and PO3R2; R1, R2 and R3 are each independently selected from the group consisting of H and C1-C12alkyl; each Ra is independently selected from the group consisting of H, F, Cl, Br, I, CH3, CH2CH3, CH(CH3)2, OH, OCH3, OCH2CH3, CF3, OCF3, NO2, NH2, and CN; each Rb is independently selected from the group consisting of H, F, Cl, Br, I, CH3, CH2CH3, CH(CH3)2, OH, OCH3, OCH2CH3, CF3, OCF3, NO2, NH2, and CN; L is a linker having from 1 to 20 atoms in the normal chain; or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240377328A1

公开(公告)日：2024-11-14

申请号：US18686805

申请日：2022-08-24

Applicant: The University of Melbourne ,  The Florey Institute of Neuroscience & Mental Health

Inventor： Gawain MCCOLL ,  David Allan SIMPSON ,  Liam Terres HALL ,  Erin Susanne GRANT

IPC: G01N21/64 ,  G01N33/90

Abstract: A method for determining one or more properties of a molecular metal ligand in a sample comprises the steps of: providing a quantum sensor: exposing the quantum sensor to the sample: applying an illumination signal to the quantum sensor for a first predetermined duration: and detecting a photoluminescence intensity emitted from the quantum sensor. A characteristic of the detected photoluminescence intensity is indicative of one of the properties of the molecular metal ligand in the sample.

公开(公告)号：US20240369580A1

公开(公告)日：2024-11-07

申请号：US18773152

申请日：2024-07-15

Applicant: THE UNIVERSITY OF MELBOURNE ,  THE FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH

Inventor： Wah Chin BOON ,  Ute ROESSNER ,  Thusitha Wasantha Thilaka PASINGHE ,  Enie LEI

IPC: G01N33/68 ,  A61K31/575 ,  G01N33/50 ,  G01N33/92

Abstract: The present invention generally relates to method for evaluating and improving cognitive function in a subject. In particular, the invention generally relates to methods for evaluating cognitive function in a subject by determining the level of cholesteryl esters in a subject, and to improving cognitive function in a subject comprising the administration of cholesteryl oleate, or analogues thereof.

公开(公告)号：US11938016B2

公开(公告)日：2024-03-26

申请号：US16943883

申请日：2020-07-30

Applicant: The University of Melbourne

Inventor： Nicholas Lachlan Opie ,  Thomas James Oxley ,  Gil Simon Rind ,  Stephen Michael Ronayne ,  Sam Emmanuel John

IPC: A61B5/00 ,  A61B5/24 ,  A61B5/283 ,  A61B5/291 ,  A61F2/06 ,  A61F2/90 ,  A61N1/05 ,  A61B5/0215 ,  A61F2/88

CPC classification number: A61F2/06 ,  A61B5/24 ,  A61B5/283 ,  A61B5/291 ,  A61B5/4052 ,  A61B5/4064 ,  A61B5/6862 ,  A61F2/90 ,  A61N1/0529 ,  A61B5/0215 ,  A61B5/4836 ,  A61B5/7207 ,  A61B2505/09 ,  A61F2/88 ,  A61F2230/0067 ,  A61F2250/0001

Abstract: Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.

公开(公告)号：US20230272048A1

公开(公告)日：2023-08-31

申请号：US18007859

申请日：2021-06-10

Applicant: The University of Melbourne

Inventor： Damian PURCELL ,  Behnaz HEYDARCHI

IPC: C07K16/08 ,  C12N15/63 ,  A61P31/18

CPC classification number: C07K16/081 ,  C12N15/63 ,  A61P31/18 ,  C07K2317/76 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92

Abstract: The invention relates to antigen binding sites, antibodies and fragments thereof, as well as compositions, kits and uses thereof for the treatment, attenuation and/or prevention of human immunodeficiency virus type 1 (HIV-1).

公开(公告)号：US20230193389A1

公开(公告)日：2023-06-22

申请号：US17967277

申请日：2022-10-17

Applicant: ITEK VENTURES PTY LTD ,  The University of Melbourne ,  Central Adelaide Local Health Network Incorporated

Inventor： Sarah Elizabeth Heron ,  Leanne Michelle Dibbens ,  Samuel Frank Berkovic ,  Ingrid Eileen Scheffer ,  John Charles Mulley

IPC: C12Q1/6883 ,  C07K14/705 ,  C07K14/47 ,  C07K16/18 ,  G01N27/447

CPC classification number: C12Q1/6883 ,  C07K14/705 ,  C07K14/47 ,  C07K16/18 ,  G01N27/447 ,  C12Q2600/156 ,  C12Q2600/118 ,  C12Q2600/136

Abstract: The present invention related to the proline rich transmembrane protein 2 (PRRT2) gene, and the identification of mutations and variations in PRRT2 that give rise to seizure and movement disorders. Accordingly, the present invention provides methods for the diagnosis or prognosis of such disorders by identifying alterations in the PRRT2 gene. Identification of alterations in the PRRT2 gene also enables the identification of subjects with an increased likelihood of having an offspring predisposed to such disorders. The present invention also provides an isolated nucleic acid molecule comprising an alteration in the PRRT2 gene, wherein said alteration produces a seizure and/or movement disorder phenotype. Also provided is an isolated PRRT2 polypeptide that comprises an alteration which produces a seizure and/or movement disorder phenotype. Furthermore, the present invention provides kit for diagnosing or prognosing a seizure and/or movement disorder in a subject, or for identifying a subject with an increased likelihood of having an offspring predisposed to a seizure and/or movement disorder, wherein the kit includes one or more components for testing for the presence of an alteration in the PRRT2 gene in the subject.

公开(公告)号：US20230146291A1

公开(公告)日：2023-05-11

申请号：US18087672

申请日：2022-12-22

Applicant: The University of Melbourne

Inventor： Alastair Stewart ,  Christine Keenan ,  Trudi Harris

IPC: A61K31/519 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/58 ,  A61K31/573 ,  A61P35/00 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04

CPC classification number: A61K31/519 ,  A61K31/58 ,  A61K31/444 ,  A61K31/506 ,  A61K31/573 ,  A61K31/4439 ,  A61K45/06 ,  A61P35/00 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04

Abstract: The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs. The present invention also provides a method of treating or preventing a condition of the airway or lung involving fibrosis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1 or an inhibitor of ALK5, thereby treating or preventing a condition of the airway or lung involving fibrosis in a subject.