公开(公告)号：US10703737B2

公开(公告)日：2020-07-07

申请号：US16351809

申请日：2019-03-13

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Donald R. Menick ,  Chung-Jen James Chou ,  Daniel Herr ,  Xiaoyang Li

IPC: C07D311/82 ,  A61P9/10

Abstract: The present invention relates to histone deacetylase inhibitors, and to pharmaceutical compositions comprising the compounds, useful for the treatment of ischemia-reperfusion injury and for cardioprotection.

公开(公告)号：US20170369847A1

公开(公告)日：2017-12-28

申请号：US15543701

申请日：2016-01-15

Applicant: Clemson University Research Foundation ,  MUSC Foundation for Research Development ,  The University of Chicago

Inventor： Ying Mei ,  Tan Yu ,  Dylan Richards ,  Donald R. Menick ,  Bozhi Tian

IPC: C12N5/077 ,  A61K35/34 ,  G01N33/50 ,  A61L27/30 ,  A61L27/38

CPC classification number: C12N5/0657 ,  A61K35/34 ,  A61L27/306 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3886 ,  A61L2400/12 ,  A61L2430/20 ,  C12N2503/02 ,  C12N2506/45 ,  C12N2513/00 ,  C12N2533/10 ,  G01N33/5061

Abstract: Provided herein are tissues containing semiconductor nanomaterials and methods of preparing and using the same.

公开(公告)号：US10988735B2

公开(公告)日：2021-04-27

申请号：US15543701

申请日：2016-01-15

Applicant: Clemson University Research Foundation ,  MUSC Foundation for Research Development ,  The University of Chicago

Inventor： Ying Mei ,  Tan Yu ,  Dylan Richards ,  Donald R. Menick ,  Bozhi Tian

IPC: C12N5/077 ,  G01N33/50 ,  A61K35/34 ,  A61L27/30 ,  A61L27/38

Abstract: Described herein are tissues containing semiconductor nanomaterials. In some embodiments, the tissues include vascular cells, cardiomyocytes, and/or cardiac fibroblasts. The tissue may be scaffold-free. In some embodiments, the tissue includes an electrically conductive network. The tissue may exhibit synchronized electrical signal propagation within the tissue. In some embodiments, the tissue exhibits increased functional assembly of cardiac cells and/or increased cardiac specific functions compared to a cardiac tissue prepared using a conventional tissue culture method. Methods of preparing and using such tissues are also described herein.

公开(公告)号：US20190284154A1

公开(公告)日：2019-09-19

申请号：US16351809

申请日：2019-03-13

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Donald R. Menick ,  Chung-Jen James Chou ,  Daniel Herr ,  Xiaoyang Li

IPC: C07D311/82 ,  A61P9/10

Abstract: The present invention relates to histone deacetylase inhibitors, and to pharmaceutical compositions comprising the compounds, useful for the treatment of ischemia-reperfusion injury and for cardioprotection.