公开(公告)号：US20240122986A1

公开(公告)日：2024-04-18

申请号：US18543191

申请日：2023-12-18

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Shikhar MEHROTRA ,  Shilpak CHATTERJEE

IPC: A61K35/17 ,  A61K9/00 ,  A61K35/26 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61K9/0019 ,  A61K35/26 ,  A61K39/39558 ,  A61K45/06 ,  A61P35/00 ,  C07K16/249 ,  C07K16/2896 ,  C07K16/30 ,  C12N5/0636 ,  C12N5/0638 ,  C07K2317/55 ,  C07K2317/76 ,  C12N2501/15 ,  C12N2501/2301 ,  C12N2501/2306 ,  C12N2501/2312 ,  C12N2501/2323 ,  C12N2501/599

Abstract: The present disclosure provides methods of producing hybrid Th1/Th17 cells. Also provided herein are methods of treating cancer comprising targeting the CD38-mediated metabolic axis.

公开(公告)号：US20190255111A1

公开(公告)日：2019-08-22

申请号：US16347743

申请日：2017-11-08

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Shikhar MEHROTRA ,  Shilpak CHATTERJEE

IPC: A61K35/17 ,  A61K35/26 ,  C07K16/24 ,  C07K16/30 ,  C12N5/0783 ,  C07K16/28 ,  A61K9/00 ,  A61P35/00

Abstract: The present disclosure provides methods of producing hybrid Th1/Th17 cells. Also provided herein are methods of treating cancer comprising targeting the CD38-mediated metabolic axis.