公开(公告)号：US11963980B2

公开(公告)日：2024-04-23

申请号：US16095828

申请日：2017-04-25

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Chrystal M. Paulos ,  Michelle H. Nelson ,  Stefanie R. Bailey

IPC: A61K35/17 ,  A61K38/19 ,  A61K39/00 ,  A61P35/00 ,  C12N5/0783 ,  C12N5/16

CPC classification number: A61K35/17 ,  A61K38/19 ,  A61K39/0011 ,  A61K39/001156 ,  A61K39/001168 ,  A61P35/00 ,  C12N5/0636 ,  C12N5/163 ,  A61K2039/5156 ,  A61K2039/5158 ,  C12N2510/00 ,  G01N2800/52

Abstract: Provided herein are methods for the production of activated CD26high T cells by co-stimulation with inducible coactivator (ICOS). Further provided are methods for treatment of cancer by administration of the of activated CD26high T cells as an adoptive T cell therapy.