专利检索 ap:("MUSC FOUNDATION FOR RESEARCH DEVELOPMENT") AND inv:"Zihai Li" 第 1 页

1.

发明授权
Methods for treatment and diagnosis of cancer by targeting glycoprotein A repetitions predominant (GARP) and for providing effective immunotherapy alone or in combination 有权

公开(公告)号：US11046782B2

公开(公告)日：2021-06-29

申请号：US16089498

申请日：2017-03-30

申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

发明人： Zihai Li

IPC分类号： C07K16/34 , C07K16/30 , C07K16/28 , A61P35/00 , A61K9/00 , A61K31/675 , A61K31/7076 , A61K45/06 , A61K39/395 , A61K39/00

摘要： Isolated or recombinant monoclonal antibodies that bind to GARP are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. Further provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of an anti-platelet agent and a T cell therapy.