公开(公告)号：US20240190995A1

公开(公告)日：2024-06-13

申请号：US18383464

申请日：2023-10-24

申请人： Donaldson Company, Inc.

发明人： Jinxiang Zhou ,  Graham Temples

IPC分类号： C07K16/34 ,  A61K35/16 ,  B01D15/20 ,  B01D15/38 ,  B01J20/26 ,  B01J20/28 ,  B01J20/32

CPC分类号： C07K16/34 ,  A61K35/16 ,  B01D15/203 ,  B01D15/3809 ,  B01J20/264 ,  B01J20/28033 ,  B01J20/3219 ,  B01J20/3278

摘要： Separation media that includes a support substrate and a plurality of separation ligands immobilized on the support substrate. The plurality of separation ligands include an affinity capable of recognizing and binding to blood type antigen recognizing domain. Methos of making the separation media and methods of using the separation media.

公开(公告)号：US11945857B2

公开(公告)日：2024-04-02

申请号：US17126396

申请日：2020-12-18

申请人： THE UAB RESEARCH FOUNDATION

发明人： Max D. Cooper ,  Brantley R. Herrin ,  Matthew N. Alder

IPC分类号： C07K16/12 ,  C07K16/10 ,  C07K16/34

CPC分类号： C07K16/1278 ,  C07K16/1018 ,  C07K16/1063 ,  C07K16/34 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/76

摘要： Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs). More particularly, disclosed are a variety of antigen specific polypeptides, including soluble, monoclonal, and multivalent forms, as well as methods of using the polypeptides, antibodies that bind the antigen specific polypeptides, and nucleic acids, vectors and expression systems that encode the polypeptides. Antigen specific polypeptides that selectively bind pathogens, like anthrax, and carbohydrates, like blood group determinants, are specifically disclosed.

公开(公告)号：US11046782B2

公开(公告)日：2021-06-29

申请号：US16089498

申请日：2017-03-30

申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

发明人： Zihai Li

IPC分类号： C07K16/34 ,  C07K16/30 ,  C07K16/28 ,  A61P35/00 ,  A61K9/00 ,  A61K31/675 ,  A61K31/7076 ,  A61K45/06 ,  A61K39/395 ,  A61K39/00

摘要： Isolated or recombinant monoclonal antibodies that bind to GARP are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. Further provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of an anti-platelet agent and a T cell therapy.

公开(公告)号：US10781265B2

公开(公告)日：2020-09-22

申请号：US15988875

申请日：2018-05-24

申请人： Development Center for Biotechnology

发明人： Chia-Cheng Wu ,  Szu-Liang Lai ,  Yu-Jung Chen ,  Chih-Yung Hu ,  Tzu-Yin Lin

IPC分类号： C07K16/34

摘要： A humanized anti-Globo H antibody, or an scFv or Fab fragment thereof, comprising a heavy-chain variable domain having three complementary regions consisting of HCDR1, HCDR2, and HCDR3 and a light-chain variable domain having three complementary regions consisting of LCDR1, LCDR2, and LCDR3, wherein the sequence of HCDR1 is GYISSDQILN (SEQ ID NO:4), the sequence of HCDR2 is RIYPVTGVTQYXHKFVG (SEQ ID NO:5, wherein X is any amino acid), and the sequence of HCDR3 is GETFDS (SEQ ID NO:6), wherein the sequence of LCDR1 is KSNQNLLX′SGNRRYZLV (SEQ ID NO:7, wherein X′ is F, Y, or W, and Z is C, G, S or T), the sequence of LCDR2 is WASDRSF (SEQ ID NO:8), and the sequence of LCDR3 is QQHLDIPYT (SEQ ID NO:9).

公开(公告)号：US20200247903A1

公开(公告)日：2020-08-06

申请号：US16757053

申请日：2018-10-19

申请人： CSL LTD. ,  Canadian Blood Services

发明人： Alan Lazarus ,  Fabian Kaesermann ,  Sandra Koernig ,  Andrew Crow

IPC分类号： C07K16/34 ,  C07K16/28 ,  C07K16/42

摘要： The invention relates to an antibody to a red blood cell for use in treating or preventing an inflammatory disorder, and to methods of treating or preventing an inflammatory disorder comprising administering to a subject in need thereof a therapeutically effective amount of an antibody to a red blood cell.

公开(公告)号：US20190177436A1

公开(公告)日：2019-06-13

申请号：US16217290

申请日：2018-12-12

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Kishor Devalaraja-Narashimha

IPC分类号： C07K16/44 ,  C07K16/34 ,  C07K16/40 ,  A61P9/12 ,  A61P3/06 ,  A61P7/04 ,  A61P9/10 ,  C07K14/47

摘要： The present invention relates to combinations of anti-C5 antibodies and antigen-binding fragments which have been determined to exhibit superior activity relative to that of a single anti-C5 antibody or fragment. The combinations include anti-C5 antibodies and antigen-binding fragments which do not compete with one another from C5 binding. Bispecific antibodies comprising antigen-binding domains which do not compete and/or bind the same epitope on C5 are also provided. Compositions and therapeutic methods relating to such anti-C5 combinations and bispecific antibodies are provided herein.

公开(公告)号：US10293058B2

公开(公告)日：2019-05-21

申请号：US15136295

申请日：2016-04-22

申请人： CureVac AG

发明人： Mariola Fotin-Mleczek ,  Aleksandra Kowalczyk ,  Regina Heidenreich ,  Patrick Baumhof ,  Jochen Probst ,  Karl-Josef Kallen

IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K48/00 ,  A61K38/19 ,  A61K38/20 ,  C12N15/117 ,  A61K9/00 ,  A61K38/17 ,  A61K39/145 ,  A61K39/39 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  C12N7/00 ,  C07K16/34 ,  A61K39/12 ,  A61K39/00

摘要： The present invention relates to RNA containing compositions for use in the treatment or prophylaxis of tumor and/or cancer diseases, to a pharmaceutical composition, to a kit and to uses of the RNA containing compositions for the treatment or prophylaxis of tumor and/or cancer diseases.

公开(公告)号：US20180299465A1

公开(公告)日：2018-10-18

申请号：US15949200

申请日：2018-04-10

申请人： LU License AB

发明人： Jill R. Storry ,  Magnus Jöud ,  Björn Nilsson ,  Martin L. Olsson

IPC分类号： G01N33/68 ,  C07K16/34 ,  G01N33/80 ,  C07K7/08 ,  A61K35/18 ,  C07K14/00 ,  C12N15/113 ,  C12Q1/6881 ,  C12Q1/6827

摘要： The present invention relates to methods and tools for discriminating between Vel negative and Vel positive phenotypes. The invention is thus useful for determining Vel blood group status of individuals about to receive blood transfusion.

公开(公告)号：US09989537B2

公开(公告)日：2018-06-05

申请号：US14431424

申请日：2013-10-01

申请人： LU License AB

发明人： Jill R. Storry ,  Magnus Jöud ,  Björn Nilsson ,  Martin L. Olsson

IPC分类号： G01N33/68 ,  A61K35/18 ,  C07K7/08 ,  C07K16/34 ,  C12Q1/68 ,  G01N33/80 ,  C07K14/00

CPC分类号： G01N33/6854 ,  A61K35/18 ,  C07K7/08 ,  C07K14/00 ,  C07K16/34 ,  C07K2317/34 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/531 ,  C12Q1/6827 ,  C12Q1/6881 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/80

摘要： The present invention relates to methods and tools for discriminating between Vel negative and Vel positive phenotypes. The invention is thus useful for determining Vel blood group status of individuals about to receive blood transfusion.

公开(公告)号：US20170210821A1

公开(公告)日：2017-07-27

申请号：US15327629

申请日：2015-07-21

申请人： Bloodworks

发明人： James Charles Zimring

IPC分类号： C07K16/34

CPC分类号： C07K16/34 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92

摘要： Compositions and methods of using antibodies that are able to recognize single amino acid polymorphisms in a protein are provided. Compositions are disclosed which may be used for blood typing or to block hemolytic transfusion reactions and/or hemolytic disease of the fetus and newborn.