公开(公告)号：US20180215802A1

公开(公告)日：2018-08-02

申请号：US15747805

申请日：2016-07-21

Applicant: MUSC Foundation for Research Development

Inventor： Galina S. Bogatkevich ,  Yuichiro Shirai ,  Richard M. Silver

IPC: C07K14/705 ,  A61P17/00 ,  A61K38/17 ,  A61K45/06

CPC classification number: C07K14/705 ,  A61K38/00 ,  A61K38/177 ,  A61K45/06 ,  A61P17/00 ,  C07K14/71 ,  C07K2319/50

Abstract: The invention provides anti-fibrotic peptides derived from the C-terminal region of the MET receptor tyrosine kinase. Polynucleotides encoding these peptides, host cells transformed with the polynucleotides, and methods of using these peptides and polynucleotides are included in the invention. Uses of these peptides, polynucleotides and expression vectors include the treatment of fibrosis in a subject.

公开(公告)号：US10344071B2

公开(公告)日：2019-07-09

申请号：US15747805

申请日：2016-07-21

Applicant: MUSC Foundation for Research Development

Inventor： Galina S. Bogatkevich ,  Yuichiro Shirai ,  Richard M. Silver

IPC: C07K14/705 ,  A61K45/06 ,  C07K14/71 ,  A61P17/00 ,  A61K38/17 ,  A61K38/00

Abstract: The invention provides anti-fibrotic peptides derived from the C-terminal region of the MET receptor tyrosine kinase. Polynucleotides encoding these peptides, host cells transformed with the polynucleotides, and methods of using these peptides and polynucleotides are included in the invention. Uses of these peptides, polynucleotides and expression vectors include the treatment of fibrosis in a subject.

公开(公告)号：US20190352368A1

公开(公告)日：2019-11-21

申请号：US16441045

申请日：2019-06-14

Applicant: MUSC Foundation for Research Development

Inventor： Galina S. Bogatkevich ,  Yuichiro Shirai ,  Richard M. Silver

IPC: C07K14/705 ,  A61P17/00 ,  A61K45/06 ,  A61K38/17 ,  C07K14/71

Abstract: The invention provides anti-fibrotic peptides derived from the C-terminal region of the MET receptor tyrosine kinase. Polynucleotides encoding these peptides, host cells transformed with the polynucleotides, and methods of using these peptides and polynucleotides are included in the invention. Uses of these peptides, polynucleotides and expression vectors include the treatment of fibrosis in a subject.