公开(公告)号：US09901566B1

公开(公告)日：2018-02-27

申请号：US15401250

申请日：2017-01-09

Applicant: Macau University of Science and Technology

Inventor： Liang Liu ,  Ting Li ,  Guoyuan Zhu ,  Fen Yang

IPC: A61K31/365

CPC classification number: A61K31/365

Abstract: A method of treating a subject, in particular a human, suffering from an autoimmune disease, preferably but not exclusively selected from systemic lupus erythematosus, multiple sclerosis or rheumatoid arthritis includes the step of administering an effective amount of a limonoid to the subject. The present invention further relates to methods of inhibiting the differentiation of T helper 17 cells, T helper 1 cells, T helper 2 cells and/or regulatory T cells and a method of screening substances for their inhibition of one or more of T helper 17 cell, T helper 1 cell, T helper 2 cell and/or regulatory T cell differentiation that may be used to treat an autoimmune disease. This invention provides highly advantageous and promising treatment options for autoimmune diseases, namely for attenuating inflammatory lymphocyte function.