公开(公告)号：US09018196B2

公开(公告)日：2015-04-28

申请号：US14251664

申请日：2014-04-14

Applicant: Macau University of Science and Technology

Inventor： Liang Liu ,  Ting Li ,  Fenggen Yan

IPC: A61K31/353 ,  A61K31/573

CPC classification number: A61K31/353 ,  A61K31/573 ,  A61K2300/00

Abstract: This invention provides a method of preventing and/or treating thymus degeneration comprising administering an effective amount of dihydromyricetin to a subject in need thereof, in which the degeneration is induced by dexamethasone. In one embodiment, the thymus degeneration is induced during the course of treatment of inflammation by dexamethasone.

Abstract translation: 本发明提供了一种预防和/或治疗胸腺变性的方法，包括向有需要的受试者施用有效量的二氢黄芪素，其中由地塞米松引起变性。 在一个实施方案中，在用地塞米松治疗炎症过程中诱导胸腺变性。

公开(公告)号：US09955676B2

公开(公告)日：2018-05-01

申请号：US14620141

申请日：2015-02-11

Applicant: Macau University of Science and Technology

Inventor： Liang Liu ,  Ting Li ,  Kam Wai Wong ,  Zhihong Jiang ,  Hua Zhou

IPC: A01K67/027 ,  C12N15/00 ,  A61K49/00 ,  G01N33/573 ,  A61K31/70 ,  G01N33/574

CPC classification number: A01K67/0278 ,  A01K2207/12 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/0368 ,  A61K49/0008 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/91215 ,  G01N2800/102 ,  G01N2800/44

Abstract: The present invention provides an in vivo platform for identifying and determining therapeutic or prophylactic activity of test compounds in delay-type hypersensitivity (DTH) and other inflammatory or cancerous diseases mediated by activation of IKK-βC46A mutants. The in vivo platform of the present invention is a non-human transgenic mammal, e.g., a mouse model, with a site directed mutagenesis at a cysteine residue replaced by alanine in IKK-β protein kinase. The site directed mutagenesis is introduced by a specially designed targeting vector containing a transversion in exon 3 of the Ikbkb genes encoding the IKK-β. The present invention also provides methods for generating the transgenic mammal and for determining and identifying compounds that can inhibit activation of IKK-βC46A mutants.

公开(公告)号：US09901566B1

公开(公告)日：2018-02-27

申请号：US15401250

申请日：2017-01-09

Applicant: Macau University of Science and Technology

Inventor： Liang Liu ,  Ting Li ,  Guoyuan Zhu ,  Fen Yang

IPC: A61K31/365

CPC classification number: A61K31/365

Abstract: A method of treating a subject, in particular a human, suffering from an autoimmune disease, preferably but not exclusively selected from systemic lupus erythematosus, multiple sclerosis or rheumatoid arthritis includes the step of administering an effective amount of a limonoid to the subject. The present invention further relates to methods of inhibiting the differentiation of T helper 17 cells, T helper 1 cells, T helper 2 cells and/or regulatory T cells and a method of screening substances for their inhibition of one or more of T helper 17 cell, T helper 1 cell, T helper 2 cell and/or regulatory T cell differentiation that may be used to treat an autoimmune disease. This invention provides highly advantageous and promising treatment options for autoimmune diseases, namely for attenuating inflammatory lymphocyte function.