公开(公告)号：US20190202802A1

公开(公告)日：2019-07-04

申请号：US15861641

申请日：2018-01-03

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong JIANG ,  Li-Ping BAI ,  Xiaobo ZHOU ,  Kam Wai Vincent WONG ,  Zhiyuan ZHENG ,  Yuen Kwan Betty LAW

IPC: C07D401/12 ,  A61P35/00 ,  C07D413/14

CPC classification number: C07D401/12 ,  A61P35/00 ,  C07D413/14

Abstract: One embodiment provides a compound of Formula I that activates autophagy, a pharmaceutical composition and use thereof:

公开(公告)号：US20180305300A1

公开(公告)日：2018-10-25

申请号：US15495949

申请日：2017-04-24

Applicant: Macau University of Science and Technology

Inventor： Guo-Yuan ZHU ,  Zhi-Hong JIANG ,  Ji YANG ,  Xiao-Jun YAO ,  Xin LIU ,  Jing FU ,  Li-Ping BAI ,  Liang LIU

IPC: C07C237/26 ,  C07C231/24

CPC classification number: A61K31/00 ,  A61P25/28 ,  C07C235/82 ,  C07C2603/97

Abstract: One example embodiment is a lignanamide that includes a benzo-angular triquinane skeleton. The lignanamide is represented by formula (I) and any derivative of the formula (I), in which R is represented by —OH or —OCH3. Another example embodiment relates to a method of treating neurodegenerative disease by administering the lignanamide of the formula (I) to a person in need thereof.