公开(公告)号：US20170030904A1

公开(公告)日：2017-02-02

申请号：US14883622

申请日：2015-10-15

Applicant: Macau University of Science and Technology

Inventor： Liang LIU ,  Jing-Rong WANG ,  Weina GAO ,  Leefong YAU ,  Hao HUANG ,  Qiong MENG ,  Tiantian TONG ,  Zhi-Hong JIANG

IPC: G01N33/564 ,  B01L3/00

CPC classification number: G01N33/564 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/10 ,  B01L2300/069 ,  G01N1/40 ,  G01N1/405 ,  G01N30/08 ,  G01N30/6095 ,  G01N30/7266 ,  G01N33/48 ,  G01N2030/085 ,  G01N2030/8836 ,  G01N2400/10 ,  G01N2440/38 ,  G01N2800/102

Abstract: The present invention discloses a method of determining the presence of autoimmune disease with the use of glycan biomarkers. A method of improving the detection sensitivity of trace glycans from a mixture of glycans and a microfluidic chip therefor are also disclosed.

Abstract translation: 本发明公开了一种使用聚糖生物标志物测定自身免疫性疾病的存在的方法。 还公开了一种从聚糖和微流体芯片的混合物中提高痕量聚糖的检测灵敏度的方法。

公开(公告)号：US20210254066A1

公开(公告)日：2021-08-19

申请号：US17247265

申请日：2020-12-06

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong JIANG ,  Kai-Yue CAO ,  Yu PAN ,  Tong-Meng YAN

IPC: C12N15/113

Abstract: A method of treating a subject suffering from cancer comprising a step of administering an effective amount of a group of double-stranded RNA molecules to the subject, wherein the RNA molecule is isolated or derived from a bacteria of the genus Escherichia. A method of inhibiting growth or proliferation of cancer cells comprising a step of contacting said cells with said RNA molecule; and a pharmaceutical composition for treating cancer comprising said RNA molecule and a pharmaceutically tolerable excipient. Also a double-stranded RNA molecule and a recombinant vector comprising the double-stranded RNA molecule.

公开(公告)号：US20210052630A1

公开(公告)日：2021-02-25

申请号：US16999051

申请日：2020-08-20

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong JIANG ,  Kua HU ,  Tong-Meng YAN

IPC: A61K31/7105 ,  A61K47/54 ,  A61P9/00

Abstract: Application of transfer RNA Molecules and their derived fragments for prevention or treatment of heart disease. The present invention provides a method of preventing or treating a subject suffering from heart diseases comprising administration of transfer RNA molecules and fragments derived from transfer RNA molecules or its functional variants or homologous to the subject, wherein the RNA molecules isolated from or derived from a plant of the genus Panax. The present invention also provides a pharmaceutical composition for the prevention or treatment of heart diseases comprising said effective amount of RNA molecule and a pharmaceutically tolerable vector, virus or excipient. The present invention provides a method for the prevention or treatment of a subject suffering from a heart disease. It is found that transfer RNA molecules from ginseng are particularly effective in the treatment of heart diseases, and also have a restorative effect on the myocardial cytoskeleton after ischemia-reperfusion injury.

公开(公告)号：US20190202802A1

公开(公告)日：2019-07-04

申请号：US15861641

申请日：2018-01-03

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong JIANG ,  Li-Ping BAI ,  Xiaobo ZHOU ,  Kam Wai Vincent WONG ,  Zhiyuan ZHENG ,  Yuen Kwan Betty LAW

IPC: C07D401/12 ,  A61P35/00 ,  C07D413/14

CPC classification number: C07D401/12 ,  A61P35/00 ,  C07D413/14

Abstract: One embodiment provides a compound of Formula I that activates autophagy, a pharmaceutical composition and use thereof:

公开(公告)号：US20190178885A1

公开(公告)日：2019-06-13

申请号：US16281122

申请日：2019-02-21

Applicant: Macau University of Science and Technology

Inventor： Liang LIU ,  Jing-Rong WANG ,  Weina GAO ,  Leefong YAU ,  Hao HUANG ,  Qiong MENG ,  Tiantian TONG ,  Zhi-Hong JIANG

IPC: G01N33/564 ,  B01L3/00 ,  G01N1/40 ,  G01N30/08 ,  G01N30/60 ,  G01N30/72

Abstract: The present invention discloses a method of determining the presence of autoimmune disease with the use of glycan biomarkers. A method of improving the detection sensitivity of trace glycans from a mixture of glycans and a microfluidic chip therefor are also disclosed.

公开(公告)号：US20180305300A1

公开(公告)日：2018-10-25

申请号：US15495949

申请日：2017-04-24

Applicant: Macau University of Science and Technology

Inventor： Guo-Yuan ZHU ,  Zhi-Hong JIANG ,  Ji YANG ,  Xiao-Jun YAO ,  Xin LIU ,  Jing FU ,  Li-Ping BAI ,  Liang LIU

IPC: C07C237/26 ,  C07C231/24

CPC classification number: A61K31/00 ,  A61P25/28 ,  C07C235/82 ,  C07C2603/97

Abstract: One example embodiment is a lignanamide that includes a benzo-angular triquinane skeleton. The lignanamide is represented by formula (I) and any derivative of the formula (I), in which R is represented by —OH or —OCH3. Another example embodiment relates to a method of treating neurodegenerative disease by administering the lignanamide of the formula (I) to a person in need thereof.