公开(公告)号：US09974766B2

公开(公告)日：2018-05-22

申请号：US14953860

申请日：2015-11-30

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Yuen Kwan Law ,  Thomas Efferth ,  Onat Kadioglu ,  Liang Liu

IPC: A61K31/352 ,  A61K31/704 ,  A61K31/337

CPC classification number: A61K31/352 ,  A61K31/337 ,  A61K31/704 ,  A61K2300/00

Abstract: Prenylated isoflavones are suitable to specifically inhibit P-glycoprotein in multidrug-resistant cancer cells leading to an accumulation of cytotoxic compounds or therapeutic compounds in the cells while having exceptionally increased cytotoxic activity specifically towards multidrug-resistant cancer cells and while allowing for an increased activity of chemotherapeutic compounds towards which the cells are resistant.Also in accordance with the present invention is a method for specifically targeting cancer cells with multidrug-resistance as well as a method of potentiating the activity of a chemotherapeutic compound in multidrug-resistant cancer cells. In a further aspect, a kit including a prenylated isoflavone and a chemotherapeutic compound is provided.

公开(公告)号：US20170151212A1

公开(公告)日：2017-06-01

申请号：US14953860

申请日：2015-11-30

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Yuen Kwan Law ,  Thomas Efferth ,  Onat Kadioglu ,  Liang Liu

IPC: A61K31/352 ,  A61K31/337 ,  A61K31/704

CPC classification number: A61K31/352 ,  A61K31/337 ,  A61K31/704 ,  A61K2300/00

Abstract: Prenylated isoflavones are suitable to specifically inhibit P-glycoprotein in multidrug-resistant cancer cells leading to an accumulation of cytotoxic compounds or therapeutic compounds in the cells while having exceptionally increased cytotoxic activity specifically towards multidrug-resistant cancer cells and while allowing for an increased activity of chemotherapeutic compounds towards which the cells are resistant.Also in accordance with the present invention is a method for specifically targeting cancer cells with multidrug-resistance as well as a method of potentiating the activity of a chemotherapeutic compound in multidrug-resistant cancer cells. In a further aspect, a kit including a prenylated isoflavone and a chemotherapeutic compound is provided.