公开(公告)号：US20210254066A1

公开(公告)日：2021-08-19

申请号：US17247265

申请日：2020-12-06

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong JIANG ,  Kai-Yue CAO ,  Yu PAN ,  Tong-Meng YAN

IPC: C12N15/113

Abstract: A method of treating a subject suffering from cancer comprising a step of administering an effective amount of a group of double-stranded RNA molecules to the subject, wherein the RNA molecule is isolated or derived from a bacteria of the genus Escherichia. A method of inhibiting growth or proliferation of cancer cells comprising a step of contacting said cells with said RNA molecule; and a pharmaceutical composition for treating cancer comprising said RNA molecule and a pharmaceutically tolerable excipient. Also a double-stranded RNA molecule and a recombinant vector comprising the double-stranded RNA molecule.

公开(公告)号：US20210052630A1

公开(公告)日：2021-02-25

申请号：US16999051

申请日：2020-08-20

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong JIANG ,  Kua HU ,  Tong-Meng YAN

IPC: A61K31/7105 ,  A61K47/54 ,  A61P9/00

Abstract: Application of transfer RNA Molecules and their derived fragments for prevention or treatment of heart disease. The present invention provides a method of preventing or treating a subject suffering from heart diseases comprising administration of transfer RNA molecules and fragments derived from transfer RNA molecules or its functional variants or homologous to the subject, wherein the RNA molecules isolated from or derived from a plant of the genus Panax. The present invention also provides a pharmaceutical composition for the prevention or treatment of heart diseases comprising said effective amount of RNA molecule and a pharmaceutically tolerable vector, virus or excipient. The present invention provides a method for the prevention or treatment of a subject suffering from a heart disease. It is found that transfer RNA molecules from ginseng are particularly effective in the treatment of heart diseases, and also have a restorative effect on the myocardial cytoskeleton after ischemia-reperfusion injury.