公开(公告)号：US09884046B1

公开(公告)日：2018-02-06

申请号：US15632406

申请日：2017-06-26

Applicant: Macau University of Science and Technology

Inventor： Xiao Jun Yao ,  Lai Han Elaine Leung ,  Liang Liu ,  Xing Xing Fan ,  Chun Xie

IPC: A61K31/428 ,  C07D277/72 ,  G01N33/574 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/68 ,  A61K38/00

CPC classification number: A61K31/428 ,  A61K38/00 ,  C07D277/72 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/57484 ,  G01N33/68

Abstract: One embodiment relates to a method of treating lung cancer by administering a compound of formula I to a patient. Another embodiment relates to a method of treating cancer with a KRAS mutation that includes administering to a patient the compound with the following formula I:

公开(公告)号：US09884047B1

公开(公告)日：2018-02-06

申请号：US15632407

申请日：2017-06-26

Applicant: Macau University of Science and Technology

Inventor： Xiao Jun Yao ,  Lai Han Elaine Leung ,  Liang Liu ,  Xing Xing Fan ,  Chun Xie

IPC: A61K31/428 ,  G01N33/574 ,  C07D277/72 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/68 ,  A61K38/00

CPC classification number: A61K31/428 ,  A61K38/00 ,  C07D277/72 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/57484 ,  G01N33/68

Abstract: One example embodiment relates to a method of treating non-small cell lung cancer by administering a compound of formula (I) to a patient. Another example embodiment relates to a method of inhibiting progress of tumor growth in a patient with cancer, wherein tumor cells of the cancer have a mutant V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) gene, and the method includes administering to the patient the compound with the following formula I: