-
公开(公告)号：US20110144091A1
公开(公告)日：2011-06-16
申请号：US12961714
申请日：2010-12-07
申请人： Macklin Brian Arnold , Thomas James Beauchamp , Emily Jane Canada , Erik James Hembre , Jianliang Lu , John Robert Rizzo , John Mehnert Schaus , Qing Shi
发明人： Macklin Brian Arnold , Thomas James Beauchamp , Emily Jane Canada , Erik James Hembre , Jianliang Lu , John Robert Rizzo , John Mehnert Schaus , Qing Shi
IPC分类号： A61K31/55 , C07D487/04 , A61P3/04 , A61P3/00
CPC分类号： C07D487/04
摘要： This invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof; as well as a method for treating obesity, a method for treating diabetes, and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐; 以及用于治疗肥胖症的方法，治疗糖尿病的方法和药物组合物。
-
公开(公告)号：US08299061B2
公开(公告)日：2012-10-30
申请号：US12961714
申请日：2010-12-07
申请人： Macklin Brian Arnold , Thomas James Beauchamp , Emily Jane Canada , Erik James Hembre , Jianliang Lu , John Robert Rizzo , John Mehnert Schaus , Qing Shi
发明人： Macklin Brian Arnold , Thomas James Beauchamp , Emily Jane Canada , Erik James Hembre , Jianliang Lu , John Robert Rizzo , John Mehnert Schaus , Qing Shi
IPC分类号： A01N43/00 , A61K31/55 , C07D403/00 , C07D235/02
CPC分类号： C07D487/04
摘要： This invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof; as well as a method for treating obesity, a method for treating diabetes, and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐; 以及用于治疗肥胖症的方法，治疗糖尿病的方法和药物组合物。
-
公开(公告)号：US20120302547A1
公开(公告)日：2012-11-29
申请号：US13569899
申请日：2012-08-08
申请人： Macklin Brian Arnold , Yen Dao , Kevin Matthew Gardinier , David Joseph Garmene , Steven James Green , Erik James Hembre , Jianliang Lu
发明人： Macklin Brian Arnold , Yen Dao , Kevin Matthew Gardinier , David Joseph Garmene , Steven James Green , Erik James Hembre , Jianliang Lu
IPC分类号： A61K31/4365 , A61P3/04 , A61K31/496 , C07D495/04 , A61K31/5377
CPC分类号： C07D495/04
摘要： The present invention relates to a melanin concentrating hormone antagonist compound of formula (I) wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.
摘要翻译： 本发明涉及式（I）的黑色素浓缩激素拮抗剂化合物，其中R 1，R a，R b，R 2，L 1，R 3，R 4和R 5如所定义，或其药学上可接受的盐，对映体，非对映异构体或其非对映异构体的混合物 用于治疗，肥胖和相关疾病。
-
公开(公告)号：US08263772B2
公开(公告)日：2012-09-11
申请号：US12298792
申请日：2007-06-08
申请人： Macklin Brian Arnold , Yen Dao , Kevin Matthew Gardinier , David Joseph Garmene , Steven James Green , Erik James Hembre , Jianliang Lu
发明人： Macklin Brian Arnold , Yen Dao , Kevin Matthew Gardinier , David Joseph Garmene , Steven James Green , Erik James Hembre , Jianliang Lu
IPC分类号： C07D515/04 , A61K31/4365
CPC分类号： C07D495/04
摘要： The present invention relates to a melanin concentrating hormone antagonist compound of formula (1): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.
摘要翻译： 本发明涉及式（1）的黑色素浓缩激素拮抗剂化合物：其中R1，Ra，Rb，R2，L1，R3，R4和R5如上定义，或其药学上可接受的盐，对映异构体，非对映体或非对映异构体的混合物 其用于治疗，肥胖和相关疾病。
-
公开(公告)号：US20090093456A1
公开(公告)日：2009-04-09
申请号：US12298792
申请日：2007-06-08
申请人： Macklin Brian Arnold , Yen Dao , Kevin Matthew Gardinier , David Joseph Garmene , Steven James Green , Erik James Hembre , Jianliang Lu
发明人： Macklin Brian Arnold , Yen Dao , Kevin Matthew Gardinier , David Joseph Garmene , Steven James Green , Erik James Hembre , Jianliang Lu
IPC分类号： A61K31/4365 , C07D495/04 , A61K31/5377
CPC分类号： C07D495/04
摘要： The present invention relates to a melanin concentrating hormone antagonist compound of formula (1): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.
摘要翻译： 本发明涉及式（1）的黑色素浓缩激素拮抗剂化合物：其中R1，Ra，Rb，R2，L1，R3，R4和R5如上定义，或其药学上可接受的盐，对映异构体，非对映体或非对映异构体的混合物 其用于治疗，肥胖和相关疾病。
-
公开(公告)号：US06358981B1
公开(公告)日：2002-03-19
申请号：US09744414
申请日：2001-01-23
申请人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： C07D23504
CPC分类号： C07D213/42 , C07C311/03 , C07C311/04 , C07D213/26 , C07D213/81 , C07D333/16 , C07D333/20
摘要： The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及使用某些磺酰胺衍生物增强谷氨酸受体功能。 它还涉及新型磺酰胺衍生物，其制备方法和含有它们的药物组合物。
-
公开(公告)号：US06174922B1
公开(公告)日：2001-01-16
申请号：US09251058
申请日：1999-02-23
IPC分类号： A61K3118
CPC分类号： C07C311/03 , C07C311/04 , C07C311/05 , C07C311/06 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D213/40 , C07D277/12 , C07D277/28 , C07D333/20 , C07D409/04
摘要： The present invention provides novel sulphonamide derivatives which are useful for potentiating glutamate receptor function in a mammal requiring treatment, processes for their preparation, and pharmaceutical compositions containing them.
摘要翻译： 本发明提供了可用于增强需要治疗的哺乳动物的谷氨酸受体功能的新型磺酰胺衍生物，其制备方法和含有它们的药物组合物。
-
公开(公告)号：US06713516B2
公开(公告)日：2004-03-30
申请号：US10318483
申请日：2002-12-12
申请人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61K3118
CPC分类号： C07D213/42 , C07C311/03 , C07C311/04 , C07D213/26 , C07D213/81 , C07D333/16 , C07D333/20
摘要： The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
-
公开(公告)号：US06552086B1
公开(公告)日：2003-04-22
申请号：US09744409
申请日：2001-01-23
申请人： Macklin Brian Arnold , Paul Leslie Ornstein , Edward C. R. Smith , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Macklin Brian Arnold , Paul Leslie Ornstein , Edward C. R. Smith , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61K3118
CPC分类号： C07C311/13 , C07C311/27
摘要： The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
-
公开(公告)号：US06521605B1
公开(公告)日：2003-02-18
申请号：US09744411
申请日：2001-01-23
IPC分类号： A61K3166
CPC分类号： C07F9/2475 , C07F9/58 , C07F9/59 , C07F9/6506 , C07F9/650952 , C07F9/6539 , C07F9/65515 , C07F9/655345 , C07F9/655354
摘要： The present invention provides amidophosphate derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
摘要翻译： 本发明提供了可用于增强哺乳动物中谷氨酸受体功能的酰胺磷酸酯衍生物，因此可用于治疗各种各样的病症，例如精神病和神经障碍。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.035 秒)
