公开(公告)号：US20060155335A1

公开(公告)日：2006-07-13

申请号：US10529430

申请日：2003-08-19

申请人： Magnus Ohman ,  Berit Larsson

发明人： Magnus Ohman ,  Berit Larsson

IPC分类号： A61N1/39

CPC分类号： A61N1/3962 ,  A61N1/3621 ,  A61N1/3712

摘要： An implantable cardiac stimulator, such as a cardioverter defibrillator, is operable in an autocapture mode. Following the delivery of a defibrillation or cardioversion shock, the stimulator switches from the autocapture mode to a post-shock mode, in which predetermined pacing pulse parameter settings are used for the delivery of pacing pulses. Following the expiration of a predetermined time interval, which may be extendable, the stimulator switches back to the autocapture mode.

摘要翻译： 可植入的心脏刺激器，例如心律转复除颤器，可在自动捕获模式中操作。 在除颤或心脏复律冲击的传递之后，刺激器从自动捕获模式切换到冲击后模式，其中使用预定的起搏脉冲参数设置来递送起搏脉冲。 在可以扩展的预定时间间隔期满之后，刺激器切换回自动捕获模式。

公开(公告)号：US07054688B1

公开(公告)日：2006-05-30

申请号：US09719739

申请日：1999-06-09

申请人： Åsa Uhrenius ,  Berit Larsson ,  Goran Budgifvars ,  Peter Andersson ,  Feresteh Shojaei

发明人： Åsa Uhrenius ,  Berit Larsson ,  Goran Budgifvars ,  Peter Andersson ,  Feresteh Shojaei

IPC分类号： A61N1/365

CPC分类号： A61N1/371 ,  A61N1/3716

摘要： A heart stimulator has a pulse generator which emits stimulation pulses of different amplitudes, which are delivered to a patient's heart via a lead connected to the pulse generator. The pulse generator is controlled by a control unit, in a procedure for determining a stimulation threshold value, to emit stimulation pulses of successively unidirectionally changing amplitudes. Each stimulation pulse is followed by a test pulse having a predetermined high, constant amplitude delivered in a period corresponding to the refractory period after the preceding stimulation pulse. Each test pulse has an amplitude sufficient to capture a non-refractory heart. A measurement unit is connected to the electrode lead, and measures a signal picked up by the lead after each test pulse. The measured signals are supplied to a comparator, which compares the signals following the test pulses with each other. A significant change in the measured signal after the test pulses indicates that the amplitude of the stimulation pulses has passed the threshold value.

摘要翻译： 心脏刺激器具有脉冲发生器，其发射不同振幅的刺激脉冲，其通过连接到脉冲发生器的引线传送到患者的心脏。 在用于确定刺激阈值的过程中，由控制单元控制脉冲发生器，以发射连续单向改变幅度的刺激脉冲。 每个刺激脉冲之后是具有预定的高，恒定幅度的测试脉冲，其在与先前的刺激脉冲之后的不适期相对应的时间段内递送。 每个测试脉冲具有足以捕获非难治心脏的振幅。 测量单元连接到电极引线，并且在每个测试脉冲之后测量由引线拾取的信号。 测量的信号被提供给比较器，比较测试脉冲之后的信号。 在测试脉冲之后的测量信号的显着变化表明刺激脉冲的幅度已经超过阈值。

公开(公告)号：US20100099994A1

公开(公告)日：2010-04-22

申请号：US12528160

申请日：2007-02-28

申请人： Nils Holmström ,  Andreas Blomqvist ,  Berit Larsson ,  Karin Järverud ,  Sven-Erik Hedberg

发明人： Nils Holmström ,  Andreas Blomqvist ,  Berit Larsson ,  Karin Järverud ,  Sven-Erik Hedberg

IPC分类号： A61B5/02

CPC分类号： A61B5/1107 ,  A61B5/0051 ,  A61B5/4519 ,  A61B5/6869 ,  A61N1/36578

摘要： An implantable heart analyzing device has a housing and a control circuit located within said housing. The control circuit generates an output signal adapted to actuate an activator, which is able to make a wall of the heart deflect or vibrate. The control circuit also communicates with a sensor, which can be identical with the activator, with which the movement of the heart wall can be sensed. The control circuit executes a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of the heart wall. An implantable heart analyzing includes the aforementioned heart analyzing device, as well as the activator and the sensor. The heart analyzing device and the system implement a method that results in generation of the aforementioned information concerning the tension of the heart wall.

摘要翻译： 可植入心脏分析装置具有壳体和位于所述壳体内的控制电路。 控制电路产生适于致动激活器的输出信号，其能够使心脏的壁发生偏转或振动。 控制电路还与传感器通信，传感器可以与激活器相同，通过该传感器可以感测心脏壁的移动。 控制电路执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够得出关于心壁的张力的信息。 可植入心脏分析包括上述心脏分析装置，以及活化剂和传感器。 心脏分析装置和系统实施导致产生上述关于心脏壁张力的信息的方法。

公开(公告)号：US06850800B1

公开(公告)日：2005-02-01

申请号：US09719740

申请日：2001-04-18

申请人： Åsa Uhrenius ,  Berit Larsson ,  Göran Budgifvars ,  Feresteh Shojaei

发明人： Åsa Uhrenius ,  Berit Larsson ,  Göran Budgifvars ,  Feresteh Shojaei

IPC分类号： A61N1/37

CPC分类号： A61N1/371 ,  A61N1/3712

摘要： A heart stimulator has a pulse generator which emits stimulation pulses for delivery to the heart of a patient through a lead connected to the pulse generator and introduced into the heart. The heart stimulator has an evoked response detector which includes a measuring unit for measuring electrode signals picked up by the lead. An averaging unit is supplied with the electrode signals and forms an average value of the amplitude of the respective electrode signals for each heartbeat. A comparator in the evoked response detector compares the average value for each heartbeat with two predetermined limit values and emits a signal indicating that the electrode signal results from a fusion beat if the average values are between the two limit values.

摘要翻译： 心脏刺激器具有脉冲发生器，该脉冲发生器通过连接到脉冲发生器的引线并发射到心脏中，发出刺激脉冲以输送到患者的心脏。 心脏刺激器具有诱发响应检测器，其包括用于测量由引线拾取的电极信号的测量单元。 平均单元被提供有电极信号，并且形成每个心跳的各个电极信号的振幅的平均值。 诱发响应检测器中的比较器将每个心跳的平均值与两个预定极限值进行比较，并且如果平均值在两个极限值之间，则发出指示电极信号由融合搏动产生的信号。

公开(公告)号：US07610087B2

公开(公告)日：2009-10-27

申请号：US10529430

申请日：2003-08-19

申请人： Magnus Öhman ,  Berit Larsson

发明人： Magnus Öhman ,  Berit Larsson

IPC分类号： A61N1/365

CPC分类号： A61N1/3962 ,  A61N1/3621 ,  A61N1/3712

摘要： An implantable cardiac stimulator, such as a cardioverter defibrillator, is operable in an autocapture mode. Following the delivery of a defibrillation or cardioversion shock, the stimulator switches from the autocapture mode to a post-shock mode, in which predetermined pacing pulse parameter settings are used for the delivery of pacing pulses. Following the expiration of a predetermined time interval, which may be extendable, the stimulator switches back to the autocapture mode.

摘要翻译： 可植入的心脏刺激器，例如心律转复除颤器，可在自动捕获模式中操作。 在除颤或心脏复律冲击的传递之后，刺激器从自动捕获模式切换到冲击后模式，其中使用预定的起搏脉冲参数设置来递送起搏脉冲。 在可以扩展的预定时间间隔期满之后，刺激器切换回自动捕获模式。

公开(公告)号：US06473650B1

公开(公告)日：2002-10-29

申请号：US09719738

申请日：2001-02-23

申请人： Berit Larsson ,  Asa Uhrenius ,  Peter Andersson ,  Göran Budgivars

发明人： Berit Larsson ,  Asa Uhrenius ,  Peter Andersson ,  Göran Budgivars

IPC分类号： A61N137

CPC分类号： A61N1/3712

摘要： A heart stimulator has an evoked response detector for determining evoked response in the presence of polarization. The heart stimulator produces stimulation pulses of different amplitudes via a lead introduced to the heart of the patient. The evoked response detector measures an electrode signal picked up by the lead after each stimulation pulse. In order to set an evoked response threshold value, the pulse generator of the stimulator is controlled to deliver at least two stimulation pulses with different amplitudes, at least one of these stimulation pulses having a high amplitude that exceeds the stimulation threshold value. A measuring unit in the evoked response detector measures the picked up electrode signals, and a calculating unit in the evoked response detector calculates the polarization for the high stimulation amplitude and identifies a measured electrode signal for the lowest possible stimulation amplitude from the measured electrode signals. The evoked response detector also has an analyzing unit which sets a threshold value for the measured electrode signal from the calculated polarization and lowest possible stimulation amplitude.

摘要翻译： 心脏刺激器具有用于在存在极化的情况下确定诱发反应的诱发响应检测器。 心脏刺激器通过导入患者心脏的导线产生不同振幅的刺激脉冲。 诱发响应检测器测量在每个刺激脉冲之后由引线拾取的电极信号。 为了设定诱发响应阈值，刺激器的脉冲发生器被控制以递送具有不同振幅的至少两个刺激脉冲，这些刺激脉冲中的至少一个具有超过刺激阈值的高幅度。 诱发响应检测器中的测量单元测量所拾取的电极信号，并且所述诱发响应检测器中的计算单元计算所述高刺激振幅的极化，并且从所测量的电极信号识别用于可能的最低刺激振幅的测量电极信号。 诱发响应检测器还具有分析单元，该分析单元根据所计算的极化和最低可能的刺激幅度来设置测量的电极信号的阈值。

公开(公告)号：US20080091239A1

公开(公告)日：2008-04-17

申请号：US11582211

申请日：2006-10-16

申请人： Anna-Karin Johansson ,  Kenth Nilsson ,  Cecilia Tuvstedt ,  Kjell Noren ,  Anders Bjorling ,  Andreas Blomqvist ,  Berit Larsson ,  Sven-Erik Hedberg ,  Karin Jarverud ,  Nils Holmstrom

发明人： Anna-Karin Johansson ,  Kenth Nilsson ,  Cecilia Tuvstedt ,  Kjell Noren ,  Anders Bjorling ,  Andreas Blomqvist ,  Berit Larsson ,  Sven-Erik Hedberg ,  Karin Jarverud ,  Nils Holmstrom

IPC分类号： A61N1/36 ,  A61N1/362 ,  A61N1/39

CPC分类号： A61N1/36514 ,  A61N1/3956

摘要： In a cardiac assist device and method, a microphone is placed in contact with the epicardium of the heart of a patient, and heart and lung sounds are simultaneously detected at the placement location of the microphone. The heart and lung sounds are automatically analyzed to set an appropriate cardiac therapy for the patient.

摘要翻译： 在心脏辅助装置和方法中，将麦克风放置成与患者心脏的心外膜接触，并且在麦克风的放置位置同时检测心脏和肺部的声音。 自动分析心脏和肺部声音，为患者设定适当的心脏治疗。

公开(公告)号：US06912422B1

公开(公告)日：2005-06-28

申请号：US10111907

申请日：2000-10-03

申请人： Martin Obel ,  Berit Larsson

发明人： Martin Obel ,  Berit Larsson

IPC分类号： A61N1/368 ,  A61N1/37 ,  A61N1/362

CPC分类号： A61N1/3702 ,  A61N1/3682

摘要： The invention relates to an implantable dual chamber heart stimulator comprising a stimulation threshold detector arranged to activate a stimulation threshold search algorithm to perform a stimulation threshold search at predetermined time intervals in order to determine a stimulation threshold of heart tissue. The heart stimulator comprises an AV-interval generator adapted to generate an AV-interval and a controller arranged to temporarily shorten the AV-interval to a threshold search AV-interval when this threshold search is performed. The heart stimulator further comprises AR/PR-interval measure adapted to measure the actual AR/PR conduction time in which this threshold search AV-interval is set by the AV-interval generator and the controller to the measured AR/PR-interval shortened by a predetermined time.

摘要翻译： 本发明涉及可植入双室心脏刺激器，其包括刺激阈值检测器，其被布置成激活刺激阈值搜索算法以在预定的时间间隔执行刺激阈值搜索，以便确定心脏组织的刺激阈值。 心脏刺激器包括适于产生AV间隔的AV间隔发生器和被配置为当执行该阈值搜索时将AV间隔临时缩短到阈值搜索AV间隔的控制器。 心脏刺激器还包括适于测量实际的AR / PR导通时间的AR / PR间隔测量，其中该AV间隔发生器和控制器将该阈值搜索AV间隔设置为经由缩短的测量的AR / PR间隔 一个预定的时间。

公开(公告)号：US06862474B1

公开(公告)日：2005-03-01

申请号：US10030931

申请日：2000-06-19

申请人： Berit Larsson ,  Martin Obel

发明人： Berit Larsson ,  Martin Obel

IPC分类号： A61N1/368 ,  A61N1/362

CPC分类号： A61N1/368 ,  A61N1/3682

摘要： An implantable heart stimulator has an AV-interval generator which generates a variable AV-interval and which is provided with a predetermined basic AV-interval. The heart stimulator has a counter that counts the number of times the AV-interval is changed in response to a fusion avoidance algorithm or a stimulation threshold search algorithm during a predetermined time period. The basic AV-interval is changed if the number of times counted by the counter is greater than a predetermined value.

摘要翻译： 植入式心脏刺激器具有AV间隔发生器，其产生可变AV间隔并且具有预定的基本AV间隔。 心脏刺激器具有计数器，该计数器响应于在预定时间段期间的融合避免算法或刺激阈值搜索算法来计数AV间隔的次数。 如果由计数器计数的次数大于预定值，则基本AV间隔被改变。

公开(公告)号：US06823215B2

公开(公告)日：2004-11-23

申请号：US10239969

申请日：2002-09-25

申请人： Martin Obel ,  Berit Larsson

发明人： Martin Obel ,  Berit Larsson

IPC分类号： A61N1362

CPC分类号： A61N1/3712

摘要： An implantable heart stimulator has a control and detection circuit which operates a pulse generator which emits stimulation pulses which are delivered to cardiac tissue via at least one electrode lead adapted for insertion in the heart of a patient. The electrode lead has an electrode surface which is intended to be in contact with heart tissue. The control and detection circuit performs a microinstability test by causing the pulse generator to emit a predetermined number of stimulation pulses, each having the same stimulation energy. The control and detection circuit determines a microinstability test value, representing a measure of the contact between the electrode surface and the heart tissue, as a ratio of a number of stimulation pulses, within said predetermined number of stimulation pulses, for which capture is detected, and the predetermined number of stimulation pulses.

摘要翻译： 可植入心脏刺激器具有控制和检测电路，其操作脉冲发生器，脉冲发生器发出经由适于插入患者心脏的至少一个电极引线输送到心脏组织的刺激脉冲。 电极引线具有旨在与心脏组织接触的电极表面。 控制和检测电路通过使脉冲发生器发射预定数量的刺激脉冲，每个具有相同的刺激能量来执行微稳定性测试。 控制和检测电路确定表示电极表面和心脏组织之间的接触的量度的微稳定性测试值，作为在所述预定数量的刺激脉冲之中，检测到捕获的刺激脉冲数量的比例， 和预定数量的刺激脉冲。