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公开(公告)号：US09359381B2
公开(公告)日：2016-06-07
申请号：US14653084
申请日：2013-12-17
申请人： Mahbub Ahmed , Alexander Ashall-Kelly , Louisa Gueritz , Jeffrey McKenna , Joseph McKenna , Simon Mutton , Rakesh Parmar , Jon Shepherd , Paul Wright
发明人： Mahbub Ahmed , Alexander Ashall-Kelly , Louisa Gueritz , Jeffrey McKenna , Joseph McKenna , Simon Mutton , Rakesh Parmar , Jon Shepherd , Paul Wright
IPC分类号： A61K31/519 , A61K31/542 , A61K31/5025 , A61K31/551 , C07D471/14 , C07D487/14 , C07D513/14 , C07D513/00 , A61K31/55 , A61K45/06 , C07D487/22 , C07D487/04 , C07D495/14
CPC分类号： C07D513/14 , A61K31/519 , A61K31/542 , A61K31/55 , A61K45/06 , C07D471/14 , C07D487/04 , C07D487/14 , C07D487/22 , C07D495/14 , C07D513/00
摘要： The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐; 及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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![Substituted pyrazino[1′,2′:1,2]pyrrolo[3,4-d]pyrimidines, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazines and pyrimido[4′,5′:3,4]pyrrolo[1,2-d][1,4]oxazepines for inhibiting the CFTR channel](/abs-image/US/2016/04/05/US09303035B2/abs.jpg.150x150.jpg)
2.发明授权Substituted pyrazino[1′,2′:1,2]pyrrolo[3,4-d]pyrimidines, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazines and pyrimido[4′,5′:3,4]pyrrolo[1,2-d][1,4]oxazepines for inhibiting the CFTR channel 有权取代的吡嗪并[1'，2'：1,2]吡咯并[3,4-d]嘧啶，嘧啶并[4'，5'：3,4]吡咯并[2,1-c] [1,4] 嘧啶并[4'，5'：3,4]吡咯并[1,2-d] [1,4]氧氮杂用于抑制CFTR通道公开(公告)号：US09303035B2
公开(公告)日：2016-04-05
申请号：US14109927
申请日：2013-12-17
申请人： Mahbub Ahmed , Alexander Ashall-Kelly , Graham Charles Bloomfield , Louisa Gueritz , Jeffrey McKenna , Joseph McKenna , Simon Mutton , Rakesh Parmar , Jon Sheperd , Paul Wright
发明人： Mahbub Ahmed , Alexander Ashall-Kelly , Graham Charles Bloomfield , Louisa Gueritz , Jeffrey McKenna , Joseph McKenna , Simon Mutton , Rakesh Parmar , Jon Sheperd , Paul Wright
IPC分类号： A61K31/519 , C07D239/70 , C07D487/14 , A61K31/5383 , A61K31/553 , A61K45/06 , C07D498/14
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5383 , A61K31/553 , A61K45/06 , C07D498/14
摘要： The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐; 及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US09931319B2
公开(公告)日：2018-04-03
申请号：US15197091
申请日：2016-06-29
申请人： Anne-Marie Edwards , Mahbub Ahmed , Robert Alexander Pulz , Lisa Ann Rooney , Nichola Smith , Thomas Josef Troxler
发明人： Anne-Marie Edwards , Mahbub Ahmed , Robert Alexander Pulz , Lisa Ann Rooney , Nichola Smith , Thomas Josef Troxler
IPC分类号： A61K31/4192 , A61K31/55 , C07D487/04 , C07D403/12 , C07D413/14 , C07D413/12
CPC分类号： A61K31/4192 , A61K31/55 , C07D403/12 , C07D413/12 , C07D413/14 , C07D487/04
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US09403833B2
公开(公告)日：2016-08-02
申请号：US14711693
申请日：2015-05-13
申请人： Anne-Marie Edwards , Mahbub Ahmed , Robert Alexander Pulz , Lisa Ann Rooney , Nichola Smith , Thomas Josef Troxler
发明人： Anne-Marie Edwards , Mahbub Ahmed , Robert Alexander Pulz , Lisa Ann Rooney , Nichola Smith , Thomas Josef Troxler
IPC分类号： C07D487/04 , A61K31/4192 , A61K31/55 , C07D403/12 , C07D413/14 , C07D413/12
CPC分类号： A61K31/4192 , A61K31/55 , C07D403/12 , C07D413/12 , C07D413/14 , C07D487/04
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or co-crystal thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐或共结晶; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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