-
公开(公告)号：US20160220552A1
公开(公告)日：2016-08-04
申请号：US15021471
申请日：2014-09-11
申请人： Majid MAHJOUR , Leonardo R. ALLAIN , Sutthilug THIVIRAT , Russell G. MAUS , Rebecca NOFSINGER , Lisa LUPTON , Wei XU , Francis FLANAGAN , MERCK SHARP & DOHME CORP.
发明人： Majid Mahjour , Leonardo R. Allain , Sutthilug Sotthivirat , Russell G. Maus , Rebecca Nofsinger , Lisa Lupton , Wei Xu , Francis Flanagan
IPC分类号： A61K31/4545 , A61K9/08 , A61K47/10
CPC分类号： A61K31/4545 , A61K9/08 , A61K47/10
摘要： The instant invention relates to liquid pharmaceutical compositions containing CGRP receptor antagonists. The CGRP receptor antagonist liquid pharmaceutical compositions of the instant invention are alcohol-free, low volume liquid pharmaceutical compositions that can be taken without water for the treatment of migraine headache.
摘要翻译： 本发明涉及含有CGRP受体拮抗剂的液体药物组合物。 本发明的CGRP受体拮抗剂液体药物组合物是无酒精的低体积液体药物组合物，其可以不用水而用于治疗偏头痛。
-
公开(公告)号：US20210330660A1
公开(公告)日：2021-10-28
申请号：US17114169
申请日：2020-12-07
申请人： Majid Mahjour , Leonardo R. Allain , Sutthilug Sotthivirat , Russell G. Maus , Rebecca Nofsinger , Lisa Lupton , Wei Xu , Francis Flanagan
发明人： Majid Mahjour , Leonardo R. Allain , Sutthilug Sotthivirat , Russell G. Maus , Rebecca Nofsinger , Lisa Lupton , Wei Xu , Francis Flanagan
IPC分类号： A61K31/4545 , A61K47/10 , A61K9/08
摘要： The instant invention relates to liquid pharmaceutical compositions containing CGRP receptor antagonists. The CGRP receptor antagonist liquid pharmaceutical compositions of the instant invention are alcohol-free, low volume liquid pharmaceutical compositions that can be taken without water for the treatment of migraine headache.
-
公开(公告)号：US20210085612A1
公开(公告)日：2021-03-25
申请号：US17110398
申请日：2020-12-03
发明人： Mary Ann Johnson , Leonardo Resende Allain , W. Mark Eickhoff , Craig B. Ikeda , Chad D. Brown , Francis J. Flanagan, JR. , Rebecca Nofsinger , Melanie Marota , Lisa Lupton , Paresh B. Patel , Hanmi Xi , Wei Xu
IPC分类号： A61K9/20 , A61K31/437 , A61K31/4545
摘要： The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): wherein “Ra” is independently —H or —F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
-
公开(公告)号：US20160346214A1
公开(公告)日：2016-12-01
申请号：US15115026
申请日：2015-01-30
发明人： Mary Ann Johnson , Leonardo Resende Allain , W. Mark Eickhoff , Craig B. Ikeda , Chad D. Brown , Francis J. Flanagan, JR. , Rebecca Nofsinger , Melanie Marota , Lisa Lupton , Paresh B. Patel , Hanmi Xi , Wei Xu
IPC分类号： A61K9/20 , A61K31/4545
CPC分类号： A61K9/2077 , A61K9/146 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K31/437 , A61K31/4545
摘要： The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein “Ra” is independently H or —F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
-
公开(公告)号：US20190070161A1
公开(公告)日：2019-03-07
申请号：US16125924
申请日：2018-09-10
发明人： Majid Mahjour , Leonardo R. Allain , Sutthilug Sotthivirat , Russell G. Maus , Rebecca Nofsinger , Lisa Lupton , Wei Xu , Francis Flanagan
IPC分类号： A61K31/4545 , A61K47/10 , A61K9/08
摘要： The instant invention relates to liquid pharmaceutical compositions containing CGRP receptor antagonists. The CGRP receptor antagonist liquid pharmaceutical compositions of the instant invention are alcohol-free, low volume liquid pharmaceutical compositions that can be taken without water for the treatment of migraine headache.
-
公开(公告)号：US10117836B2
公开(公告)日：2018-11-06
申请号：US15115026
申请日：2015-01-30
发明人： Mary Ann Johnson , Leonardo Resende Allain , W. Mark Eickhoff , Craig B. Ikeda , Chad D. Brown , Francis J. Flanagan, Jr. , Rebecca Nofsinger , Melanie Marota , Lisa Lupton , Paresh B. Patel , Hanmi Xi , Wei Xu
IPC分类号： A61K31/437 , A61K31/4545 , A61K9/20
摘要： The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein “Ra” is independently H or —F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
-
公开(公告)号：US20160346198A1
公开(公告)日：2016-12-01
申请号：US15116826
申请日：2015-02-04
发明人： Melanie J. Marota , Chad David Brown , Craig B. Ikeda , Mary Ann Johnson , Hanmi Xi , Wei Xu , Lixia Cai
IPC分类号： A61K9/00 , A61K9/20 , A61K31/4545 , A61K31/5365 , A61K31/551 , A61K9/28 , A61K38/06
CPC分类号： A61K9/0053 , A61K9/145 , A61K9/146 , A61K9/1694 , A61K9/2009 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/28 , A61K9/284 , A61K31/395 , A61K31/403 , A61K31/4545 , A61K31/506 , A61K31/5365 , A61K31/551 , A61K31/5513 , A61K31/664 , A61K38/06
摘要： The present disclosure is directed to disintegration systems for solid pharmaceutical dosage forms, which allow rapid disintegration of solid dosage forms that comprise solid dispersion formulations that include pharmaceutically active agents, polymers and optionally surfactants. The present disclosure is also directed to solid pharmaceutical dosage forms, such as tablets, comprising solid dispersion formulations and the disintegration systems, to methods for preparing the disintegration systems, and to methods for preparing the solid pharmaceutical dosage forms.
摘要翻译： 本公开涉及用于固体药物剂型的崩解体系，其允许包含固体分散体制剂的固体剂型的快速崩解，所述固体分散体制剂包括药物活性剂，聚合物和任选的表面活性剂。 本公开还涉及固体药物剂型，例如包含固体分散体制剂和崩解体系的片剂，制备崩解体系的方法以及制备固体药物剂型的方法。
-
公开(公告)号：US20220056067A1
公开(公告)日：2022-02-24
申请号：US17415570
申请日：2019-12-16
发明人： Daniel Skomski , Yongchao Su , Wei Xu , Marko Cubrovic
IPC分类号： C07H19/173
摘要： The present disclosure provides novel anhydrate crystalline Forms 1 and 4 of 4′-Ethynyl-2-fluoro-2′-deoxyadenosine and pharmaceutical compositions thereof, each of which may be useful for the inhibition of HIV reverse transcriptase, the treatment or prophylaxis of HIV infection and/or the treatment, prophylaxis and/or delay in the onset or progression of AIDS or ARC.
-
9.发明申请公开(公告)号：US20190231705A1
公开(公告)日：2019-08-01
申请号：US16255333
申请日：2019-01-23
IPC分类号： A61K9/51 , A61K31/4985
CPC分类号： A61K9/5161 , A61K9/5138 , A61K9/5192 , A61K31/4985
摘要： Described herein are polymeric nanoparticles that comprise {[(1R,25)-1-({[(1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]-dioxadiazacyclo-nonadecino[11,12-b]quinoxalin-8-yl]carbonyl}amino)-2-vinylcylopropyl]carbonyl}(cyclopropylsulfonyl)azanide, (i.e., grazoprevir), or a pharmaceutically acceptable salt thereof, and methods of making and using such nanoparticles.
-
公开(公告)号：US20190209478A1
公开(公告)日：2019-07-11
申请号：US16178641
申请日：2018-11-02
发明人： Mary Ann Johnson , Leonardo Resende Allain , W. Mark Eickhoff , Craig B. Ikeda , Chad D. Brown , Francis J. Flanagan, JR. , Rebecca Nofsinger , Melanie Marota , Lisa Lupton , Paresh B. Patel , Hanmi Xi , Wei Xu
IPC分类号： A61K9/20 , A61K31/4545 , A61K31/437
CPC分类号： A61K9/2077 , A61K9/146 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K31/437 , A61K31/4545
摘要： The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): wherein “Ra” is independently —H or —F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
-
-
-
-
-
-
-
-
-
搜索结果
306 条记录 (耗时 0.039 秒)