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1.发明授权Sphingolipid ceramide N-deacylase, methods for producing sphingolipids and sphingolipid derivatives, and spingolipid ceramide N-deacylase gene 失效鞘氨醇神经酰胺N-脱酰酶，鞘脂和鞘脂衍生物的制造方法，和鞘脂神经酰胺N-脱酰酶基因公开(公告)号：US06428999B1
公开(公告)日：2002-08-06
申请号：US09160036
申请日：1998-09-25
申请人： Makoto Ito , Toyohisa Kurita , Katsuhiro Kita , Noriyuki Sueyoshi , Susumu Mitsutake , Masanori Fujita , Nozomu Okino , Hiroyuki Izu , Ikunoshin Kato
发明人： Makoto Ito , Toyohisa Kurita , Katsuhiro Kita , Noriyuki Sueyoshi , Susumu Mitsutake , Masanori Fujita , Nozomu Okino , Hiroyuki Izu , Ikunoshin Kato
IPC分类号： C12N980
摘要： The present invention relates to a novel sphingolipid ceramide N-deacylase (SCDase) having a wide substrate specificity; a method for enzymatically producing a lysosphingolipid or a sphingolipid derivative using the SCDase which is useful in the fields of medicine, carbohydrate engineering, cell engineering, and the like; the lysosphingolipid or sphingolipid derivative obtained by this production method; a gene which encodes a polypeptide having an SCDase activity useful in sphingolipid technology; a method for industrially producing a polypeptide having an SCDase deacylase activity and a recombinant polypeptide thereof using a transformant to which the gene is introduced; a probe or primer which hybridizes to the gene; and an antibody or a fragment thereof which specifically binds to the polypeptide.
摘要翻译： 本发明涉及具有宽底物特异性的新型鞘脂神经酰胺N-脱酰酶（SCDase）; 使用可用于医药，碳水化合物工程，细胞工程等领域的SCDase酶促产生溶血神经鞘脂或鞘脂衍生物的方法; 通过该制造方法得到的溶血鞘脂或鞘脂衍生物; 编码具有可用于神经鞘脂技术的SCDase活性的多肽的基因; 使用引入了该基因的转化体的工业生产具有SCD酶脱酰酶活性的多肽的方法及其重组多肽; 与基因杂交的探针或引物; 以及特异性结合多肽的抗体或其片段。
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公开(公告)号：US06821761B2
公开(公告)日：2004-11-23
申请号：US10150068
申请日：2002-05-20
申请人： Makoto Ito , Toyohisa Kurita , Katsuhiro Kita , Noriyuki Sueyoshi , Susumu Mitsutake , Masanori Fujita , Nozomu Okino , Hiroyuki Izu , Ikunoshin Kato
发明人： Makoto Ito , Toyohisa Kurita , Katsuhiro Kita , Noriyuki Sueyoshi , Susumu Mitsutake , Masanori Fujita , Nozomu Okino , Hiroyuki Izu , Ikunoshin Kato
IPC分类号： C12P1300
摘要： The present invention relates to a novel sphingolipid ceramide N-deacylase (SCDase) having a wide substrate specificity; a method for enzymatically producing a lysosphingolipid or a sphingolipid derivative using the SCDase which is useful in the fields of medicine, carbohydrate engineering, cell engineering, and the like; the lysosphingolipid or sphingolipid derivative obtained by this production method; a gene which encodes a polypeptide having an SCDase activity useful in sphingolipid technology; a method for industrially producing a polypeptide having an SCDase deacylase activity and a recombinant polypeptide thereof using a transformant to which the gene is introduced; a probe or primer which hybridizes to the gene; and an antibody or a fragment thereof which specifically binds to the polypeptide.
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