利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

24 条记录 (耗时 0.02 秒)

    Intermediates and process for the production of optically active quinolonecarboxylic acid derivatives
    1.
    发明授权
    Intermediates and process for the production of optically active quinolonecarboxylic acid derivatives 失效
    用于制备光学活性喹诺酮羧酸衍生物的中间体和方法

    公开(公告)号：US07915418B2

    公开(公告)日：2011-03-29

    申请号：US10559499

    申请日：2004-06-04

    申请人： Makoto Muto ,  Manabu Miura ,  Yutaka Kitagawa

    发明人： Makoto Muto ,  Manabu Miura ,  Yutaka Kitagawa

    IPC分类号： C07D215/38

    CPC分类号： C07D215/56 ,  A01N43/42 ,  C07C51/00 ,  C07C65/21 ,  C07C225/16 ,  C07C255/43 ,  C07C2601/02 ,  C07D215/54

    摘要： Provision of a commercially advantageous method for producing an intermediate which is important for producing the antibacterial and which has a mother nucleus common to the antibacterial, and intermediates produced by such method.A method for producing a compound represented by formula (VI): which comprises the steps of treating a compound represented by formula (IV): with a base in the presence of a base to produce a compound represented by formula (V): and hydrolyzing this compound; a compound represented by formula (II): a compound represented by formula (Ia): a compound represented by formula (V): and a compound represented by formula (VI).

    摘要翻译： 提供一种商业上有利的生产中间体的方法，其对于生产抗菌剂是重要的，并且具有抗细菌共有的母核和通过这种方法制备的中间体。 一种制备由式（VI）表示的化合物的方法：其包括在碱的存在下用碱处理式（IV）表示的化合物以制备由式（V）表示的化合物的步骤：水解 这种化合物 由式（II）表示的化合物：由式（Ia）表示的化合物：由式（V）表示的化合物和由式（VI）表示的化合物。

    Intermediates and process for the production of optically active quinolonecarboxylic acid derivatives
    2.
    发明申请
    Intermediates and process for the production of optically active quinolonecarboxylic acid derivatives 失效
    用于制备光学活性喹诺酮羧酸衍生物的中间体和方法

    公开(公告)号：US20060135775A1

    公开(公告)日：2006-06-22

    申请号：US10559499

    申请日：2004-06-04

    申请人： Makoto Muto ,  Manabu Miura ,  Yutaka Kitagawa

    发明人： Makoto Muto ,  Manabu Miura ,  Yutaka Kitagawa

    IPC分类号： C07D215/36

    CPC分类号： C07D215/56 ,  A01N43/42 ,  C07C51/00 ,  C07C65/21 ,  C07C225/16 ,  C07C255/43 ,  C07C2601/02 ,  C07D215/54

    摘要： [Problem]Provision of a commercially advantageous method for producing an intermediate which is important for producing the antibacterial and which has a mother nucleus common to the antibacterial, and intermediates produced by such method. [Means to Solve the Problem] A method for producing a compound represented by formula (VI): which comprises the steps of treating a compound represented by formula (IV): with a base in the presence of a base to produce a compound represented by formula (V): and hydrolyzing this compound; a compound represented by formula (II): a compound represented by formula (Ia): a compound represented by formula (V): and a compound represented by formula (VI)

    摘要翻译： [问题]提供一种商业上有利的生产中和体的方法，该方法对于生产抗菌剂是重要的，并且具有抗细菌共有的母核以及通过这种方法生产的中间体。 解决问题的方法由式（VI）表示的化合物的制备方法：其包括在碱的存在下用碱处理由式（IV）表示的化合物的步骤，以制备由式 式（Ⅴ）：水解该化合物; 由式（II）表示的化合物：由式（Ia）表示的化合物：由式（V）表示的化合物和由式（VI）表示的化合物

    Method for producing asymmetric tetrasubstituted carbon atom-containing compound
    3.
    发明授权
    Method for producing asymmetric tetrasubstituted carbon atom-containing compound 失效
    不对称四取代碳原子化合物的制备方法

    公开(公告)号：US07928232B2

    公开(公告)日：2011-04-19

    申请号：US11914952

    申请日：2006-05-19

    申请人： Yuichiro Tani ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

    发明人： Yuichiro Tani ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

    IPC分类号： C07F5/02 ,  C07D211/00 ,  C07D209/54 ,  C07C61/04

    CPC分类号： C07C255/31 ,  C07B53/00 ,  C07C271/22 ,  C07D209/54 ,  C07D401/04

    摘要： The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent.The invention provides a method for producing a compound represented by formula (2): (wherein n is an integer of 2 to 5; R1 represents a (substituted) alkyl group or a (substituted) aryl group; and R2 represents a (substituted) alkoxycarbonyl group, a (substituted) aralkyloxycarbonyl group, a (substituted) aliphatic acyl group, or a (substituted) aromatic acyl group), which includes treating a compound represented by formula (1): (wherein n, R1, and R2 are the same as defined above; and R3 represents a hydrogen atom, a (substituted) alkyl group, or a (substituted) aralkyl group) under a hydrogen gas atmosphere in the presence of a metallic catalyst.

    摘要翻译： 本发明提供一种生产螺环氨基吡咯烷酮衍生物的工业方法，其是用于生产喹诺酮抗菌剂的中间体。 本发明提供一种制备由式（2）表示的化合物的方法：（其中n为2至5的整数; R 1表示（取代的）烷基或（取代的）芳基; R 2表示（取代的） 烷氧基羰基，（取代的）芳烷氧基羰基，（取代的）脂族酰基或（取代的）芳族酰基），其包括处理由式（1）表示的化合物：其中n，R1和R2是 在氢气气氛下，在金属催化剂的存在下，R 3表示氢原子，（取代的）烷基或（取代的）芳烷基）。

    Method of selectively introducing amino substituent
    4.
    发明申请
    Method of selectively introducing amino substituent 失效

    公开(公告)号：US20060122396A1

    公开(公告)日：2006-06-08

    申请号：US10560823

    申请日：2004-06-18

    申请人： Makoto Muto ,  Yutaka Kitagawa

    发明人： Makoto Muto ,  Yutaka Kitagawa

    IPC分类号： A61K31/4709 ,  C07D403/02

    CPC分类号： C07D401/04

    摘要： Provided are a technique for position-selectively introducing an amino group into a difluorobenzoic acid, a novel process for producing a quinolonecarboxylic acid derivative serving as an antibacterial agent, and intermediates in the production. The process comprises treating a compound represented by formula (6): with a base in a water-containing solvent. The intermediates are represented by formula (6):

    Intermediates for the production of optically active cyclopropylamine derivatives and process for the production of the intermediates
    5.
    发明授权
    Intermediates for the production of optically active cyclopropylamine derivatives and process for the production of the intermediates 有权
    用于制备光学活性环丙胺衍生物的中间体和用于生产中间体的方法

    公开(公告)号：US07994344B2

    公开(公告)日：2011-08-09

    申请号：US12429512

    申请日：2009-04-24

    申请人： Masao Fujita ,  Yutaka Kitagawa ,  Makoto Muto

    发明人： Masao Fujita ,  Yutaka Kitagawa ,  Makoto Muto

    IPC分类号： C07D207/09

    CPC分类号： C07D207/20 ,  C07B2200/07 ,  C07D207/09 ,  C07D207/12 ,  C07D207/16 ,  Y02P20/55

    摘要： A process for producing an optically active compound represented by formula (4) or a salt thereof: the process including reacting a cyclization reagent with an optically active compound represented by formula (3) or its salt: optionally in the presence of a Lewis acid, to form the compound of formula (4) or its salt, wherein, in the compounds of formula (3) and formula (4) and their salts, R1 is a protecting group, and wherein the cyclization reagent is prepared from a titanium (IV) reagent and an alkylmetal compound.

    摘要翻译： 一种制备由式（4）表示的光学活性化合物或其盐的方法：使环化试剂与由式（3）表示的光学活性化合物或其盐反应的方法：任选地在路易斯酸存在下， 形成式（4）化合物或其盐，其中在式（3）和式（4）的化合物及其盐中，R 1为保护基，其中环化试剂由钛（IV ）试剂和烷基金属化合物。

    METHOD FOR PRODUCING ASYMMETRIC TETRASUBSTITUTED CARBON ATOM-CONTAINING COMPOUND
    8.
    发明申请
    METHOD FOR PRODUCING ASYMMETRIC TETRASUBSTITUTED CARBON ATOM-CONTAINING COMPOUND 失效
    用于生产不对称四面体碳纳米管的化合物的方法

    公开(公告)号：US20110144339A1

    公开(公告)日：2011-06-16

    申请号：US13032135

    申请日：2011-02-22

    申请人： Yuichiro TANI ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

    发明人： Yuichiro TANI ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

    IPC分类号： C07D209/54 ,  C07F5/02 ,  C07D215/20

    CPC分类号： C07C255/31 ,  C07B53/00 ,  C07C271/22 ,  C07D209/54 ,  C07D401/04

    摘要： The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent. Specifically, the invention provides a method for producing a compound of formula (2): wherein n is an integer of 2 to 5; R1 is a (substituted) alkyl group or a (substituted) aryl group; and R2 represents a (substituted) alkoxycarbonyl group, a (substituted) aralkyloxycarbonyl group, a (substituted) aliphatic acyl group, or a (substituted) aromatic acyl group).

    摘要翻译： 本发明提供一种生产螺环氨基吡咯烷酮衍生物的工业方法，其是用于生产喹诺酮抗菌剂的中间体。 具体地说，本发明提供了制备式（2）化合物的方法：其中n为2至5的整数; R1是（取代的）烷基或（取代的）芳基; R2代表（取代的）烷氧基羰基，（取代的）芳烷氧基羰基，（取代的）脂族酰基或（取代的）芳族酰基）。

    Method of selectively introducing amino substituent
    9.
    发明授权
    Method of selectively introducing amino substituent 失效
    选择性引入氨基取代基的方法

    公开(公告)号：US07626029B2

    公开(公告)日：2009-12-01

    申请号：US10560823

    申请日：2004-06-18

    申请人： Makoto Muto ,  Yutaka Kitagawa

    发明人： Makoto Muto ,  Yutaka Kitagawa

    IPC分类号： C07D215/38

    CPC分类号： C07D401/04

    摘要： Provided are a technique for position-selectively introducing an amino group into a difluorobenzoic acid, a novel process for producing a quinolonecarboxylic acid derivative serving as an antibacterial agent, and intermediates in the production. The process comprises treating a compound represented by formula (6): with a base in a water-containing solvent. The intermediates are represented by formula (6):

    摘要翻译： 提供了将氨基位置选择性引入到二氟苯甲酸中的技术，用于制备用作抗菌剂的喹诺酮羧酸衍生物的新方法和制备中的中间体。 该方法包括用碱在含水溶剂中处理由式（6）表示的化合物。 中间体由式（6）表示：

    METHOD FOR PRODUCING ASYMMETRIC TETRASUBSTITUTED CARBON ATOM-CONTAINING COMPOUND
    10.
    发明申请
    METHOD FOR PRODUCING ASYMMETRIC TETRASUBSTITUTED CARBON ATOM-CONTAINING COMPOUND 失效
    用于生产不对称四面体碳纳米管的化合物的方法

    公开(公告)号：US20090054648A1

    公开(公告)日：2009-02-26

    申请号：US11914952

    申请日：2006-05-19

    申请人： Yuichiro Tani ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

    发明人： Yuichiro Tani ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

    IPC分类号： C07F5/00 ,  C07C61/04 ,  C07D209/54 ,  C07D401/02

    CPC分类号： C07C255/31 ,  C07B53/00 ,  C07C271/22 ,  C07D209/54 ,  C07D401/04

    摘要： The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent.The invention provides a method for producing a compound represented by formula (2): (wherein n is an integer of 2 to 5; R1 represents a (substituted) alkyl group or a (substituted) aryl group; and R2 represents a (substituted) alkoxycarbonyl group, a (substituted) aralkyloxycarbonyl group, a (substituted) aliphatic acyl group, or a (substituted) aromatic acyl group), which includes treating a compound represented by formula (1): (wherein n, R1, and R2 are the same as defined above; and R3 represents a hydrogen atom, a (substituted) alkyl group, or a (substituted) aralkyl group) under a hydrogen gas atmosphere in the presence of a metallic catalyst.

    摘要翻译： 本发明提供一种生产螺环氨基吡咯烷酮衍生物的工业方法，其是用于生产喹诺酮抗菌剂的中间体。 本发明提供一种制备由式（2）表示的化合物的方法：（其中n为2至5的整数; R 1表示（取代的）烷基或（取代的）芳基; R 2表示（取代的） 烷氧基羰基，（取代的）芳烷氧基羰基，（取代的）脂族酰基或（取代的）芳族酰基），其包括处理由式（1）表示的化合物：其中n，R1和R2是 在氢气气氛下，在金属催化剂的存在下，R 3表示氢原子，（取代的）烷基或（取代的）芳烷基）。