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    PROCESS FOR PRODUCTION OF QUINUCLIDINE COMPOUNDS
    1.
    发明申请
    PROCESS FOR PRODUCTION OF QUINUCLIDINE COMPOUNDS 审中-公开
    喹啉化合物的生产工艺

    公开(公告)号：US20130060036A1

    公开(公告)日：2013-03-07

    申请号：US13503382

    申请日：2010-10-21

    申请人： Yutaka Kitagawa ,  Masao Fujita ,  Kumiko Otaya

    发明人： Yutaka Kitagawa ,  Masao Fujita ,  Kumiko Otaya

    IPC分类号： C07D497/20

    CPC分类号： C07D497/20 ,  C07B57/00 ,  C07D453/00 ,  C07D453/02

    摘要： Provided is a production method for a cis-QMF, which has a low environmental burden and is industrially advantageous. Specifically provided is a production method for a cis-type 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine hydrochloride, including: reacting a cis-trans isomer mixture of 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine with p-nitrobenzoic acid; resolving the resultant product to produce a cis-type 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine p-nitrobenzoate; and converting the p-nitrobenzoate into a hydrochloride.

    摘要翻译： 提供了具有低环境负荷并且在工业上有利的顺式-QMF的制备方法。 具体提供的是顺式2-烷基螺（1,3-氧硫杂环戊烷-5,3'）奎宁环酸盐酸盐的制备方法，包括：使2-烷基螺（1,3-氧硫杂环戊烷-5 ，3'）奎宁环与对硝基苯甲酸; 分解所得产物以产生对 - 硝基苯甲酸顺式-2-烷基螺（1,3-氧硫杂环戊烷-5,3'）奎宁环; 并将对硝基苯甲酸酯转化成盐酸盐。

    DEVICE STORAGE APPARATUS FOR RAILWAY VEHICLE
    2.
    发明申请
    DEVICE STORAGE APPARATUS FOR RAILWAY VEHICLE 有权
    铁路车辆装置储存装置

    公开(公告)号：US20110234070A1

    公开(公告)日：2011-09-29

    申请号：US13025716

    申请日：2011-02-11

    申请人： Shin KATAOKA ,  Kunihiko TAKAGI ,  Yutaka KITAGAWA

    发明人： Shin KATAOKA ,  Kunihiko TAKAGI ,  Yutaka KITAGAWA

    IPC分类号： A47B81/00 ,  A47B96/00

    CPC分类号： B61C17/00

    摘要： An apparatus for storing a device for a railway vehicle, comprises a storage case having an opening at a front side, a tray accommodated into the storage case, the tray being movable forward and backward with the device mounted thereon, a lever disposed at an upper side of the tray to extend along a forward and backward direction, the lever being vertically pivotable around a pivot forward relative to a center of the tray in the forward and backward direction, an operation member coupled to a front end portion of the lever and disposed at a front side of the tray, an engagement portion provided at a rear end portion of the lever and protruding downward outside the tray, and a recess provided in the storage case, the engagement portion being fitted into the recess from above.

    摘要翻译： 一种用于存储用于铁路车辆的装置的装置，包括：前侧具有开口的存放箱，容纳在所述收纳箱内的托盘，所述托盘可安装在所述装置上的前后方向移动， 所述托盘沿着前后方向延伸，所述杠杆可相对于所述托盘的向前和向后方向的中心而绕枢轴向上竖直地枢转;联接到所述杠杆的前端部分的操作构件， 在所述托盘的前侧，设置在所述杆的后端部并且向下突出到所述托盘的下方的接合部以及设置在所述收纳壳体中的凹部，所述接合部从上方嵌入所述凹部。

    Intermediates and process for the production of optically active quinolonecarboxylic acid derivatives
    3.
    发明授权
    Intermediates and process for the production of optically active quinolonecarboxylic acid derivatives 失效
    用于制备光学活性喹诺酮羧酸衍生物的中间体和方法

    公开(公告)号：US07915418B2

    公开(公告)日：2011-03-29

    申请号：US10559499

    申请日：2004-06-04

    申请人： Makoto Muto ,  Manabu Miura ,  Yutaka Kitagawa

    发明人： Makoto Muto ,  Manabu Miura ,  Yutaka Kitagawa

    IPC分类号： C07D215/38

    CPC分类号： C07D215/56 ,  A01N43/42 ,  C07C51/00 ,  C07C65/21 ,  C07C225/16 ,  C07C255/43 ,  C07C2601/02 ,  C07D215/54

    摘要： Provision of a commercially advantageous method for producing an intermediate which is important for producing the antibacterial and which has a mother nucleus common to the antibacterial, and intermediates produced by such method.A method for producing a compound represented by formula (VI): which comprises the steps of treating a compound represented by formula (IV): with a base in the presence of a base to produce a compound represented by formula (V): and hydrolyzing this compound; a compound represented by formula (II): a compound represented by formula (Ia): a compound represented by formula (V): and a compound represented by formula (VI).

    摘要翻译： 提供一种商业上有利的生产中间体的方法，其对于生产抗菌剂是重要的，并且具有抗细菌共有的母核和通过这种方法制备的中间体。 一种制备由式（VI）表示的化合物的方法：其包括在碱的存在下用碱处理式（IV）表示的化合物以制备由式（V）表示的化合物的步骤：水解 这种化合物 由式（II）表示的化合物：由式（Ia）表示的化合物：由式（V）表示的化合物和由式（VI）表示的化合物。

    Method of selectively introducing amino substituent
    4.
    发明授权
    Method of selectively introducing amino substituent 失效
    选择性引入氨基取代基的方法

    公开(公告)号：US07626029B2

    公开(公告)日：2009-12-01

    申请号：US10560823

    申请日：2004-06-18

    申请人： Makoto Muto ,  Yutaka Kitagawa

    发明人： Makoto Muto ,  Yutaka Kitagawa

    IPC分类号： C07D215/38

    CPC分类号： C07D401/04

    摘要： Provided are a technique for position-selectively introducing an amino group into a difluorobenzoic acid, a novel process for producing a quinolonecarboxylic acid derivative serving as an antibacterial agent, and intermediates in the production. The process comprises treating a compound represented by formula (6): with a base in a water-containing solvent. The intermediates are represented by formula (6):

    摘要翻译： 提供了将氨基位置选择性引入到二氟苯甲酸中的技术，用于制备用作抗菌剂的喹诺酮羧酸衍生物的新方法和制备中的中间体。 该方法包括用碱在含水溶剂中处理由式（6）表示的化合物。 中间体由式（6）表示：

    METHOD FOR PRODUCING ASYMMETRIC TETRASUBSTITUTED CARBON ATOM-CONTAINING COMPOUND
    5.
    发明申请
    METHOD FOR PRODUCING ASYMMETRIC TETRASUBSTITUTED CARBON ATOM-CONTAINING COMPOUND 失效
    用于生产不对称四面体碳纳米管的化合物的方法

    公开(公告)号：US20090054648A1

    公开(公告)日：2009-02-26

    申请号：US11914952

    申请日：2006-05-19

    申请人： Yuichiro Tani ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

    发明人： Yuichiro Tani ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

    IPC分类号： C07F5/00 ,  C07C61/04 ,  C07D209/54 ,  C07D401/02

    CPC分类号： C07C255/31 ,  C07B53/00 ,  C07C271/22 ,  C07D209/54 ,  C07D401/04

    摘要： The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent.The invention provides a method for producing a compound represented by formula (2): (wherein n is an integer of 2 to 5; R1 represents a (substituted) alkyl group or a (substituted) aryl group; and R2 represents a (substituted) alkoxycarbonyl group, a (substituted) aralkyloxycarbonyl group, a (substituted) aliphatic acyl group, or a (substituted) aromatic acyl group), which includes treating a compound represented by formula (1): (wherein n, R1, and R2 are the same as defined above; and R3 represents a hydrogen atom, a (substituted) alkyl group, or a (substituted) aralkyl group) under a hydrogen gas atmosphere in the presence of a metallic catalyst.

    摘要翻译： 本发明提供一种生产螺环氨基吡咯烷酮衍生物的工业方法，其是用于生产喹诺酮抗菌剂的中间体。 本发明提供一种制备由式（2）表示的化合物的方法：（其中n为2至5的整数; R 1表示（取代的）烷基或（取代的）芳基; R 2表示（取代的） 烷氧基羰基，（取代的）芳烷氧基羰基，（取代的）脂族酰基或（取代的）芳族酰基），其包括处理由式（1）表示的化合物：其中n，R1和R2是 在氢气气氛下，在金属催化剂的存在下，R 3表示氢原子，（取代的）烷基或（取代的）芳烷基）。

    Device storage apparatus for railway vehicle
    7.
    发明授权
    Device storage apparatus for railway vehicle 有权
    铁路车辆设备存储装置

    公开(公告)号：US08376076B2

    公开(公告)日：2013-02-19

    申请号：US13025716

    申请日：2011-02-11

    申请人： Shin Kataoka ,  Kunihiko Takagi ,  Yutaka Kitagawa

    发明人： Shin Kataoka ,  Kunihiko Takagi ,  Yutaka Kitagawa

    IPC分类号： B60R16/04

    CPC分类号： B61C17/00

    摘要： An apparatus for storing a device for a railway vehicle, comprises a storage case having an opening at a front side, a tray accommodated into the storage case, the tray being movable forward and backward with the device mounted thereon, a lever disposed at an upper side of the tray to extend along a forward and backward direction, the lever being vertically pivotable around a pivot forward relative to a center of the tray in the forward and backward direction, an operation member coupled to a front end portion of the lever and disposed at a front side of the tray, an engagement portion provided at a rear end portion of the lever and protruding downward outside the tray, and a recess provided in the storage case, the engagement portion being fitted into the recess from above.

    摘要翻译： 一种用于存储用于铁路车辆的装置的装置，包括：前侧具有开口的存放箱，容纳在所述收纳箱内的托盘，所述托盘可安装在所述装置上的前后方向移动， 所述托盘沿着前后方向延伸，所述杠杆可相对于所述托盘的向前和向后方向的中心而绕枢轴向上竖直地枢转;联接到所述杠杆的前端部分的操作构件， 在所述托盘的前侧，设置在所述杆的后端部并且向下突出到所述托盘的下方的接合部以及设置在所述收纳壳体中的凹部，所述接合部从上方嵌入所述凹部。

    Cable guide unit water-proof device for railway vehicle
    8.
    发明授权
    Cable guide unit water-proof device for railway vehicle 失效
    铁路车辆导轨单元防水装置

    公开(公告)号：US08348204B2

    公开(公告)日：2013-01-08

    申请号：US13030825

    申请日：2011-02-18

    申请人： Shin Kataoka ,  Kunihiko Takagi ,  Yutaka Kitagawa ,  Kazuya Morita

    发明人： Shin Kataoka ,  Kunihiko Takagi ,  Yutaka Kitagawa ,  Kazuya Morita

    IPC分类号： F16L3/22 ,  H01B7/00

    CPC分类号： H02G3/088 ,  B61D49/00

    摘要： A waterproof cable guide device for a railway vehicle comprises an elastic member having a plurality of through-holes penetrating in a forward and backward direction and screw insertion holes penetrating in the forward and backward direction, the plurality of electric cables being inserted into the plurality of holes, respectively, the elastic member being divided in positions of the through-holes or having slits extending from an outer peripheral surface of the elastic member to the through-holes, respectively; a press casing surrounding a front surface and an outer peripheral surface of the elastic member so as not to cover the through-holes and provided with screw insertion holes communicating with the screw insertion holes of the elastic member; and screws inserted into the screw insertion holes, in a direction from forward, and tightened with respect to the cable guide; the screws being inserted into the screw insertion holes in the direction from forward and tightened with respect to the cable guide in a state where the electric cables are inserted into the through-holes, respectively, to cause the elastic member to be compressed by the press casing to closely contact peripheral surfaces of the electric cables.

    摘要翻译： 一种用于铁路车辆的防水电缆引导装置，包括具有沿前后方向贯穿的多个通孔的弹性构件和沿前后方向贯穿的螺钉插入孔，多个电缆插入到多个 所述弹性构件分别被分割成所述通孔的位置或具有从所述弹性构件的外周面延伸到所述通孔的狭缝; 围绕所述弹性构件的前表面和外周面的按压套，以便不覆盖所述通孔，并且设置有与所述弹性构件的所述螺钉插入孔连通的螺钉插入孔; 以及螺钉插入螺钉插入孔中的方向从前方方向相对于缆索引导件紧固; 在将电缆分别插入通孔的状态下，分别将螺钉沿相对于电缆引导件的向前和向前的方向插入螺钉插入孔中，以使弹性构件被压机压缩 壳体紧密接触电缆的外围表面。

    Method for producing asymmetric tetrasubstituted carbon atom-containing compound
    10.
    发明授权
    Method for producing asymmetric tetrasubstituted carbon atom-containing compound 失效
    不对称四取代碳原子化合物的制备方法

    公开(公告)号：US08138352B2

    公开(公告)日：2012-03-20

    申请号：US13032135

    申请日：2011-02-22

    申请人： Yuichiro Tani ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

    发明人： Yuichiro Tani ,  Yutaka Kitagawa ,  Makoto Muto ,  Toshiaki Jyono

    IPC分类号： C07D209/54

    CPC分类号： C07C255/31 ,  C07B53/00 ,  C07C271/22 ,  C07D209/54 ,  C07D401/04

    摘要： The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent. Specifically, the invention provides a method for producing a compound of formula (2): wherein n is an integer of 2 to 5; R1 is a (substituted) alkyl group or a (substituted) aryl group; and R2 represents a (substituted) alkoxycarbonyl group, a (substituted) aralkyloxycarbonyl group, a (substituted) aliphatic acyl group, or a (substituted) aromatic acyl group).

    摘要翻译： 本发明提供一种生产螺环氨基吡咯烷酮衍生物的工业方法，其是用于生产喹诺酮抗菌剂的中间体。 具体地说，本发明提供了制备式（2）化合物的方法：其中n为2至5的整数; R1是（取代的）烷基或（取代的）芳基; R2代表（取代的）烷氧基羰基，（取代的）芳烷氧基羰基，（取代的）脂族酰基或（取代的）芳族酰基）。