公开(公告)号：US5733877A

公开(公告)日：1998-03-31

申请号：US503479

申请日：1995-07-18

申请人： Makoto Sato ,  Toshiyuki Kouzaki ,  Yoko Ishihara ,  Shigeaki Yoshina ,  Masanao Nakoshi ,  Tatsushi Maeda

发明人： Makoto Sato ,  Toshiyuki Kouzaki ,  Yoko Ishihara ,  Shigeaki Yoshina ,  Masanao Nakoshi ,  Tatsushi Maeda

IPC分类号： A61K9/107 ,  A61K38/00 ,  A61K38/22 ,  A61K38/23 ,  A61K47/12 ,  A61K47/24 ,  A61K47/28 ,  C07K14/575 ,  C07K14/585 ,  C07K14/63 ,  A61K38/02

CPC分类号： A61K38/23 ,  A61K38/2214 ,  A61K38/2278 ,  A61K47/12 ,  A61K47/24 ,  A61K9/0019 ,  A61K9/107 ,  Y10S514/938

摘要： A pharmaceutical composition is disclosed comprising a fat emulsion containing microspheres and having its electric charge adjusted to a negative value and a biologically active substance selected from the group consisting of a basic peptide and a basic protein, which biologically active substance is adsorbed to the microspheres in the fat emulsion. An acidic phospholipid, a fatty acid, a bilic acid and a salt of such substances is preferred as an agent for adjusting the electric charge of the fat emulsion. Motilin derivatives, vasoactive intestinal polypeptide derivatives and calcitonin are preferred biologically active substances.

摘要翻译： 公开了一种药物组合物，其包含含有微球并将其电荷调节至负值的脂肪乳剂和选自碱性肽和碱性蛋白质的生物活性物质，所述生物活性物质被吸附到微球体上 脂肪乳液。 优选酸性磷脂，脂肪酸，二胆酸和这些物质的盐作为调节脂肪乳剂电荷的试剂。 胃动素衍生物，血管活性肠多肽衍生物和降钙素是优选的生物活性物质。