公开(公告)号：US06759234B1

公开(公告)日：2004-07-06

申请号：US08300510

申请日：1994-09-02

申请人： Malcolm L. Gefter ,  Ze′ev Shaked ,  Malcolm Morville

发明人： Malcolm L. Gefter ,  Ze′ev Shaked ,  Malcolm Morville

IPC分类号： A61K3816

CPC分类号： A61K38/16 ,  A61K39/35 ,  A61K2039/545

摘要： The present invention provides therapeutic compositions and methods for treating disease conditions in humans associated with an antigen specific immune response by the human to an antigen such as a protein antigen (i.e. allergy and autoimmune diseases). Therapeutic compositions of the invention are reproducible preparations which are suitable for human therapy. Compositions of the invention comprise at least one isolated peptide having a defined sequence of amino acid residues and the composition is capable of down regulating an antigen specific immune response to an offending antigen in a population of humans subject to the antigen specific immune response. Compositions and methods of the invention may be used to treat sensitivity to protein allergens in humans and may also be used to treat autoimmune disease such as rheumatoid arthritis, diabetes, myasthenia gravis, Grave's disease, Good Pasture's syndrome, thyroiditis and multiple sclerosis.

摘要翻译： 本发明提供用于治疗人类与人类对抗原（例如过敏和自身免疫性疾病）的抗原特异性免疫应答相关的疾病状况的治疗组合物和方法。 本发明的治疗组合物是适用于人类治疗的可重复制剂。 本发明的组合物包含具有确定的氨基酸残基序列的至少一种分离的肽，并且该组合物能够下调受抗原特异性免疫应答的人群中的违规抗原的抗原特异性免疫应答。 本发明的组合物和方法可用于治疗人类对蛋白质过敏原的敏感性，并且还可用于治疗自身免疫疾病，例如类风湿性关节炎，糖尿病，重症肌无力，格雷夫斯病，良好牧场综合征，甲状腺炎和多发性硬化。

公开(公告)号：US06268491B1

公开(公告)日：2001-07-31

申请号：US08484296

申请日：1995-06-07

申请人： Richard D. Garman ,  Julia L. Greenstein ,  Mei-chang Kuo ,  Bruce L. Rogers ,  Henry M. Franzen ,  Xian Chen ,  Sean Evans ,  Ze′ev Shaked

发明人： Richard D. Garman ,  Julia L. Greenstein ,  Mei-chang Kuo ,  Bruce L. Rogers ,  Henry M. Franzen ,  Xian Chen ,  Sean Evans ,  Ze′ev Shaked

IPC分类号： C07H2104

CPC分类号： C07K14/415 ,  A61K38/00 ,  A61K39/00 ,  C07K14/43531 ,  C07K14/4705 ,  C07K2319/00 ,  C07K2319/40 ,  C12N15/62 ,  G01N33/5091

摘要： The present invention provides isolated peptides of the major protein allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprises at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.

摘要翻译： 本发明提供了Dermatophagoides属主要蛋白质过敏原的分离的肽。 本发明范围内的肽包含至少一种T细胞表位，或优选至少两种选自变应原Der p I，Der p II，Der f I或Der f II的蛋白质变应原的T细胞表位。 本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的修饰肽。 本发明还提供了编码本发明的肽的核酸序列。 还提供了治疗或诊断对个体中的尘螨的敏感性的方法和包含本发明的一种或多种肽的治疗组合物。