公开(公告)号：US10562956B2

公开(公告)日：2020-02-18

申请号：US15331942

申请日：2016-10-24

申请人： Mallinckrodt Pharma IP Trading D.A.C., an Irish Designated Activity Company

发明人： Abraham Bout ,  Joseph Grimbergen ,  Jacob Koopman

IPC分类号： C07K14/75 ,  C07H21/04 ,  C12N15/09

摘要： The present invention relates to nucleotide sequences encoding a fibrinogen alpha, beta or gamma chain. The sequences are optimized for expression in a eukaryotic cell culture system. Such optimized nucleotide sequences allow for the efficient expression of recombinant fibrinogen and variants thereof in intact form in a eukaryotic cell culture system.

公开(公告)号：US20170037108A1

公开(公告)日：2017-02-09

申请号：US15331942

申请日：2016-10-24

申请人： Mallinckrodt Pharma IP Trading D.A.C., an Irish Designated Activity Company

发明人： Abraham Bout ,  Joseph Grimbergen ,  Jacob Koopman

IPC分类号： C07K14/75

摘要： The present invention relates to nucleotide sequences encoding a fibrinogen alpha, beta or gamma chain. The sequences are optimized for expression in a eukaryotic cell culture system. Such optimized nucleotide sequences allow for the efficient expression of recombinant fibrinogen and variants thereof in intact form in a eukaryotic cell culture system.

摘要翻译： 本发明涉及编码纤维蛋白原α，β或γ链的核苷酸序列。 优化序列在真核细胞培养系统中表达。 这种优化的核苷酸序列允许在真核细胞培养系统中以完整形式有效地表达重组纤维蛋白原及其变体。