公开(公告)号：US06264616B1

公开(公告)日：2001-07-24

申请号：US09562052

申请日：2000-05-01

申请人： Manuel Don

发明人： Manuel Don

IPC分类号： A61B500

CPC分类号： A61B5/04845 ,  A61B5/12 ,  A61B5/6817

摘要： A diagnostic procedure first records a patient's auditory brainstem response (ABR) to each of a plurality of auditory stimuli. The stimuli comprise 60 dB nHL clicks using high pass noise masking procedures to isolate the cochlear response within specific frequency bands. These derived band ABRs are temporally shifted to align the wave V peak amplitudes. The time-shifted responses are then summed to create the stacked ABR. The stacked wave V ABR amplitude is compared to a threshold value. The stacked wave V ABR amplitudes for patients having small (less than or equal to 1 cm.) intracanalicular tumors are measurably lower than those for otherwise similar individuals without tumors.

摘要翻译： 诊断程序首先将患者的听觉脑干反应（ABR）记录到多个听觉刺激中的每一个。 刺激包括60dB nHL点击使用高通噪声屏蔽程序来隔离特定频带内的人工耳蜗响应。 这些导出的波段ABR在时间上偏移以对准波V峰值振幅。 然后将时移响应相加以创建堆叠的ABR。 将堆叠波V ABR振幅与阈值进行比较。 具有小（小于或等于1厘米）的小脑内肿瘤的患者的堆叠波V ABR幅度可以显着低于没有肿瘤的其他相似个体的波幅V ABR幅度。

公开(公告)号：US06196977B1

公开(公告)日：2001-03-06

申请号：US09300059

申请日：1999-04-26

申请人： Yvonne S. Sininger ,  Martyn Hyde ,  Manuel Don

发明人： Yvonne S. Sininger ,  Martyn Hyde ,  Manuel Don

IPC分类号： A61B500

CPC分类号： A61B5/12 ,  A61B5/04845

摘要： A method for determining the statistical probability that an auditory brainstem response (ABR) to an acoustic stimulus is present in a human test subject. The method employs an algorithm that provides a continuously evolving estimate of the probability of ABR presence as acquired data accumulates. The algorithm employs a radical modification of a conventional FSP approach.

摘要翻译： 用于确定在人类测试对象中出现声学刺激的听觉脑干反应（ABR）的统计概率的方法。 该方法采用一种算法，其提供了随着获取的数据累积的ABR存在的概率的连续演进的估计。 该算法采用常规FSP方法的根本修改。

公开(公告)号：US20050273018A1

公开(公告)日：2005-12-08

申请号：US10863559

申请日：2004-06-07

申请人： Manuel Don

发明人： Manuel Don

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B5/04 ,  A61B5/0484 ,  A61B5/12 ,  A61M31/00 ,  G06F17/00

CPC分类号： A61B5/04845 ,  A61B5/121

摘要： A procedure for diagnosing cochlear hydrops is based, in part, on an analysis of the patient's auditory brainstem response (ABR) to stimuli. The patient's ABR to a broadband click stimulus is recorded. A plurality of masked ABR's are also recorded, wherein the stimulus is masked by high-pass noise with a plurality of high-pass cut-off frequencies. The latency difference between the wave V component in the unmasked click alone response and the undermasked wave V component of a low cut-off frequency high-pass response is then calculated. If an undermasked component is not present, the normal wave V component is used. The measured latency difference is combined with another measure, such as the wave V amplitude ratio. A distribution of the combined measure is then plotted for the population and a threshold established for diagnosing cochlear hydrops. Alternatively, the joint distribution of the individual measures may be used in situations where the individual measures are known to be independent.

摘要翻译： 用于诊断耳蜗水肿的程序部分地基于对患者的听觉脑干反应（ABR）对刺激的分析。 记录患者的ABR到宽带点击刺激。 还记录了多个屏蔽的ABR，其中激励被具有多个高通截止频率的高通噪声掩蔽。 然后计算未屏蔽单击响应中的波V分量与低截止频率高通响应的未掩蔽波V分量之间的延迟差。 如果不存在未掩蔽的分量，则使用正常波V分量。 测量的等待时间差与另一个测量结合，例如波V振幅比。 然后针对群体绘制组合度量的分布，并为诊断耳蜗水肿建立阈值。 另外，个别措施的共同分配也可以用于个别措施是独立的。

公开(公告)号：US07223246B2

公开(公告)日：2007-05-29

申请号：US10863559

申请日：2004-06-07

申请人： Manuel Don

发明人： Manuel Don

IPC分类号： A61B5/00

CPC分类号： A61B5/04845 ,  A61B5/121

摘要： A procedure for diagnosing cochlear hydrops is based, in part, on an analysis of the patient's auditory brainstem response (ABR) to stimuli. The patient's ABR to a broadband click stimulus is recorded. A plurality of masked ABR's are also recorded, wherein the stimulus is masked by high-pass noise with a plurality of high-pass cut-off frequencies. The latency difference between the wave V component in the unmasked click alone response and the undermasked wave V component of a low cut-off frequency high-pass response is then calculated. If an undermasked component is not present, the normal wave V component is used. The measured latency difference is combined with another measure, such as the wave V amplitude ratio. A distribution of the combined measure is then plotted for the population and a threshold established for diagnosing cochlear hydrops. Alternatively, the joint distribution of the individual measures may be used in situations where the individual measures are known to be independent.

摘要翻译： 用于诊断耳蜗水肿的程序部分地基于对患者的听觉脑干反应（ABR）对刺激的分析。 记录患者的ABR到宽带点击刺激。 还记录了多个屏蔽的ABR，其中激励被具有多个高通截止频率的高通噪声掩蔽。 然后计算未屏蔽单击响应中的波V分量与低截止频率高通响应的未掩蔽波V分量之间的延迟差。 如果不存在未掩蔽的分量，则使用正常波V分量。 测量的等待时间差与另一个测量结合，例如波V振幅比。 然后针对群体绘制组合度量的分布，并为诊断耳蜗水肿建立阈值。 另外，个别措施的共同分配也可以用于个别措施是独立的。

公开(公告)号：US07141022B1

公开(公告)日：2006-11-28

申请号：US10818806

申请日：2004-04-05

申请人： Manuel Don ,  Curtis W. Ponton

发明人： Manuel Don ,  Curtis W. Ponton

IPC分类号： A61B5/00

CPC分类号： A61B5/04845 ,  A61B5/7242 ,  G06K9/00543

摘要： In a diagnostic system wherein a patient's auditory brainstem response (ABR) to each of a plurality of auditory stimuli is recorded and wherein a plurality of derived-band ABRs representing cochlear responses in a plurality of respective frequency bands are constructed, the derived-band ABRs are temporarily aligned based on observable peaks in integrated, detrended derived-band waveforms.

摘要翻译： 在诊断系统中，其中记录了对多个听觉刺激中的每一个的患者的听觉脑干响应（ABR），并且其中构成了表示多个相应频带中的耳蜗响应的多个导出带ABR，所述导出的带ABR 基于集成的去衍射波段波形中的可见峰值临时对准。

公开(公告)号：US6080112A

公开(公告)日：2000-06-27

申请号：US79411

申请日：1998-05-13

申请人： Manuel Don

发明人： Manuel Don

IPC分类号： A61B10/00 ,  A61B5/12 ,  A61B5/00

CPC分类号： A61B5/04845 ,  A61B5/12 ,  A61B5/6817

摘要： A diagnostic procedure first records a patient's auditory brainstem response (ABR) to each of a plurality of auditory stimuli. The stimuli comprise 60 dB nHL clicks using high pass noise masking procedures to isolate the cochlear response within specific frequency bands. These derived band ABRs are temporally shifted to align the wave V peak amplitudes. The time-shifted responses are then summed to create the stacked ABR. The stacked wave V ABR amplitude is compared to a threshold value. The stacked wave V ABR amplitudes for patients having small (less than or equal to 1 cm.) intracanalicular tumors are measurably lower than those for otherwise similar individuals without tumors.

摘要翻译： 诊断程序首先将患者的听觉脑干反应（ABR）记录到多个听觉刺激中的每一个。 刺激包括60dB nHL点击使用高通噪声屏蔽程序来隔离特定频带内的人工耳蜗响应。 这些导出的波段ABR在时间上偏移以对准波V峰值振幅。 然后将时移响应相加以创建堆叠的ABR。 将堆叠波V ABR振幅与阈值进行比较。 具有小（小于或等于1厘米）的小脑内肿瘤的患者的堆叠波V ABR幅度可以显着低于没有肿瘤的其他相似个体的波幅V ABR幅度。