公开(公告)号：US20240002534A1

公开(公告)日：2024-01-04

申请号：US18253702

申请日：2021-11-22

申请人： Marc Andre BAILLY ,  Kalyan CHAKRAVARTHY ,  Ghassan Najib FAYAD ,  Laurence FAYAT-DILMAN ,  Esther KOFMAN ,  Masahisa HANDA ,  Jennifer E. O'NEIL ,  Rachel L. PALTE ,  Giovanna SCAPIN ,  Shahriar Shane TAREMI ,  MERCK SHARP & DOHME LLC

发明人： Marc Andre Bailly ,  Kalyan Chakravarthy ,  Ghassan Najib Fayad ,  Laurence Fayadat-Dilman ,  Esther Kofman ,  Masahisa Handa ,  Jennifer E. O'Neil ,  Rachel Lynn Palte ,  Giovanna Scapin ,  Shahriar Shane Taremi

IPC分类号： C07K16/40 ,  C07K16/28 ,  C12N15/85

CPC分类号： C07K16/40 ,  C07K16/2818 ,  C07K16/2827 ,  C12N15/85 ,  C12N2800/107

摘要： Arginase 1 binders that inhibit the activity of human Arginase 1 (hArg1) and comprise human antibodies and antigen-binding fragments thereof comprising human VH and VL are described. These Arginase 1 binders present an alternative mechanism for inhibiting hArg1 activity and highlight the ability to utilize binders as probes in the discovery and development of peptide and small molecule inhibitors for enzymes in general.

公开(公告)号：US20240002535A1

公开(公告)日：2024-01-04

申请号：US18253709

申请日：2021-11-22

申请人： MERCK SHARP & DOHME LLC

发明人： Marc Andre Bailly ,  Kalyan Chakravarthy ,  Ghassan Najib Fayad ,  Laurence Fayadat-Dilman ,  Veronica Juan ,  Esther Kofman ,  Masahisa Handa ,  Jennifer E. O'Neil ,  Rachel Lynn Palte ,  Giovanna Scapin ,  Shahriar Shane Taremi

IPC分类号： C07K16/40

CPC分类号： C07K16/40 ,  A61K2039/505

摘要： Arginase 1 binders that inhibit activity of hArg1, which comprise humanized anti-human Arginase 1 (hArg1) antibodies and antigen-binding fragments thereof obtained from mouse monoclonal antibodies comprising mouse VH and VL, are described. These Arginase 1 binders present an alternative mechanism for inhibiting hArg1 activity and highlight the ability to utilize binders as probes in the discovery and development of peptide and small molecule inhibitors for enzymes in general.

公开(公告)号：US20240002533A1

公开(公告)日：2024-01-04

申请号：US18253691

申请日：2021-11-22

申请人： MERCK SHARP & DOHME LLC

发明人： Marc Andre Bailly ,  Kalyan Chakravarthy ,  Ghassan Najib Fayad ,  Laurence Fayadat-Dilman ,  Veronica Juan ,  Esther Kofman ,  Heping Lin ,  Jennifer E. O'Neil ,  Rachel Lynn Palte ,  Giovanna Scapin ,  Hussam Hisham Shaheen ,  Tao Wang

IPC分类号： C07K16/40 ,  C07K16/28

CPC分类号： C07K16/40 ,  C07K16/2818 ,  C07K16/2827 ,  C12Y305/03001 ,  A61K2039/507

摘要： Arginase 1 binders comprising human antibodies and antigen-binding fragments thereof that inhibit the activity of human Arginase 1 (hArg1) are described. These Arginase 1 binders present an alternative mechanism for inhibiting hArg1 activity and highlight the ability to utilize binders as probes in the discovery and development of peptide and small molecule inhibitors for enzymes in general.