公开(公告)号：US20240002534A1

公开(公告)日：2024-01-04

申请号：US18253702

申请日：2021-11-22

申请人： Marc Andre BAILLY ,  Kalyan CHAKRAVARTHY ,  Ghassan Najib FAYAD ,  Laurence FAYAT-DILMAN ,  Esther KOFMAN ,  Masahisa HANDA ,  Jennifer E. O'NEIL ,  Rachel L. PALTE ,  Giovanna SCAPIN ,  Shahriar Shane TAREMI ,  MERCK SHARP & DOHME LLC

发明人： Marc Andre Bailly ,  Kalyan Chakravarthy ,  Ghassan Najib Fayad ,  Laurence Fayadat-Dilman ,  Esther Kofman ,  Masahisa Handa ,  Jennifer E. O'Neil ,  Rachel Lynn Palte ,  Giovanna Scapin ,  Shahriar Shane Taremi

IPC分类号： C07K16/40 ,  C07K16/28 ,  C12N15/85

CPC分类号： C07K16/40 ,  C07K16/2818 ,  C07K16/2827 ,  C12N15/85 ,  C12N2800/107

摘要： Arginase 1 binders that inhibit the activity of human Arginase 1 (hArg1) and comprise human antibodies and antigen-binding fragments thereof comprising human VH and VL are described. These Arginase 1 binders present an alternative mechanism for inhibiting hArg1 activity and highlight the ability to utilize binders as probes in the discovery and development of peptide and small molecule inhibitors for enzymes in general.

公开(公告)号：US20240002535A1

公开(公告)日：2024-01-04

申请号：US18253709

申请日：2021-11-22

申请人： MERCK SHARP & DOHME LLC

发明人： Marc Andre Bailly ,  Kalyan Chakravarthy ,  Ghassan Najib Fayad ,  Laurence Fayadat-Dilman ,  Veronica Juan ,  Esther Kofman ,  Masahisa Handa ,  Jennifer E. O'Neil ,  Rachel Lynn Palte ,  Giovanna Scapin ,  Shahriar Shane Taremi

IPC分类号： C07K16/40

CPC分类号： C07K16/40 ,  A61K2039/505

摘要： Arginase 1 binders that inhibit activity of hArg1, which comprise humanized anti-human Arginase 1 (hArg1) antibodies and antigen-binding fragments thereof obtained from mouse monoclonal antibodies comprising mouse VH and VL, are described. These Arginase 1 binders present an alternative mechanism for inhibiting hArg1 activity and highlight the ability to utilize binders as probes in the discovery and development of peptide and small molecule inhibitors for enzymes in general.

公开(公告)号：US20090142261A1

公开(公告)日：2009-06-04

申请号：US11833726

申请日：2007-08-03

申请人： Jeff Hsu ,  Linda Masat ,  Judy Abraham ,  Masahisa Handa ,  Siew Schleyer

发明人： Jeff Hsu ,  Linda Masat ,  Judy Abraham ,  Masahisa Handa ,  Siew Schleyer

IPC分类号： A61K51/00 ,  C07K16/18 ,  G01N33/566 ,  C12N15/11 ,  C12N5/06 ,  C12P21/04 ,  C12N15/00 ,  G01N33/574 ,  A61K39/395

CPC分类号： C07K16/30 ,  C07K16/2866 ,  C07K2317/56 ,  C07K2317/75 ,  C07K2317/77 ,  C07K2317/92

摘要： EphB3-specific antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating cancer.

摘要翻译： 提供EphB3特异性抗体以及含有此类抗体的药物组合物，含有药物组合物的试剂盒，以及预防和治疗癌症的方法。

公开(公告)号：US07378091B2

公开(公告)日：2008-05-27

申请号：US10309762

申请日：2002-12-02

申请人： Jean Gudas ,  Ian Foltz ,  Masahisa Handa ,  Michael L. Gallo

发明人： Jean Gudas ,  Ian Foltz ,  Masahisa Handa ,  Michael L. Gallo

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/32

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/77

摘要： The present invention relates generally to the generation and characterization of anti-CA IX monoclonal antibodies. The invention further relates to the use of such anti-CA IX antibodies in the diagnosis and treatment of disorders associated with increased activity of CA IX, in particular, tumors such as colorectal cancer, renal cell carcinoma (RCC), cervical and other cancers of epithelial origin.

摘要翻译： 本发明一般涉及抗CA IX单克隆抗体的产生和表征。 本发明还涉及这种抗CA IX抗体在诊断和治疗与增加CA IX活性相关的疾病，特别是肿瘤如结肠直肠癌，肾细胞癌（RCC），子宫颈癌和其他癌症的肿瘤中的用途 上皮起源。

公开(公告)号：US20080145894A1

公开(公告)日：2008-06-19

申请号：US11831691

申请日：2007-07-31

申请人： Masahisa Handa ,  Arnold Horwitz ,  Eddie Bautista ,  Robyn Cotter

发明人： Masahisa Handa ,  Arnold Horwitz ,  Eddie Bautista ,  Robyn Cotter

IPC分类号： C12P21/04

CPC分类号： C07K16/00 ,  C12N7/00 ,  C12N15/85 ,  C12N2710/16221 ,  C12N2710/16243 ,  C12N2800/108 ,  C12N2820/10 ,  C12N2820/55 ,  C12N2820/60 ,  C12N2830/42

摘要： Recombinant expression vectors are provided comprising a 3′UTR of a light chain and an Epstein-Barr virus origin of replication. Also provided are host cells comprising such vectors and methods of producing recombinant protein with such vectors. Additional methods of producing a recombinant protein involve contacting cells with a first and second vector, each of which encode a different polypeptide chain, and wherein the second vector is present in an amount which is about 1.5 to 2.5 times as much as that of the first vector. Cells also can be transfected with a recombinant transient expression vector encoding a protein and are cultured in a medium in a membrane-enhanced culturing vessel to produce recombinant protein.

摘要翻译： 提供重组表达载体，其包含轻链的3'UTR和Epstein-Barr病毒复制起点。 还提供了包含这种载体的宿主细胞和用这种载体产生重组蛋白的方法。 生产重组蛋白质的其它方法包括使细胞与第一和第二载体接触，第一和第二载体各自编码不同的多肽链，其中第二载体的存在量为第一载体的约1.5至2.5倍 向量。 细胞也可以用编码蛋白质的重组瞬时表达载体转染，并在膜增强培养容器中的培养基中培养以产生重组蛋白。

公开(公告)号：US20060121604A1

公开(公告)日：2006-06-08

申请号：US11295006

申请日：2005-12-05

申请人： Masahisa Handa ,  Arnold Horwitz ,  Eddie Bautista ,  Robyn Cotter

发明人： Masahisa Handa ,  Arnold Horwitz ,  Eddie Bautista ,  Robyn Cotter

IPC分类号： C12Q1/68 ,  C12N15/63 ,  C12N15/74 ,  C12N15/00 ,  C12N15/70 ,  C12N15/09

CPC分类号： C07K16/00 ,  C12N7/00 ,  C12N15/85 ,  C12N2710/16221 ,  C12N2710/16243 ,  C12N2800/108 ,  C12N2820/10 ,  C12N2820/55 ,  C12N2820/60 ,  C12N2830/42

摘要： Recombinant expression vectors are provided comprising a 3′ UTR of a light chain and an Epstein-Barr virus origin of replication. Also provided are host cells comprising such vectors and methods of producing recombinant protein with such vectors. Additional methods of producing a recombinant protein involve contacting cells with a first and second vector, each of which encode a different polypeptide chain, and wherein the second vector is present in an amount which is about 1.5 to 2.5 times as much as that of the first vector. Cells also can be transfected with a recombinant transient expression vector encoding a protein and are cultured in a medium in a membrane-enhanced culturing vessel to produce recombinant protein.

摘要翻译： 提供重组表达载体，其包含轻链的3'UTR和Epstein-Barr病毒复制起点。 还提供了包含这种载体的宿主细胞和用这种载体产生重组蛋白的方法。 生产重组蛋白质的其它方法包括使细胞与第一和第二载体接触，第一和第二载体各自编码不同的多肽链，其中第二载体的存在量为第一载体的约1.5至2.5倍 向量。 细胞也可以用编码蛋白质的重组瞬时表达载体转染，并在膜增强培养容器中的培养基中培养以产生重组蛋白。

公开(公告)号：US4684567A

公开(公告)日：1987-08-04

申请号：US874101

申请日：1986-06-13

申请人： Tadashi Okamoto ,  Sumiyuki Matsubara ,  Masahisa Handa

发明人： Tadashi Okamoto ,  Sumiyuki Matsubara ,  Masahisa Handa

IPC分类号： B28B3/26 ,  B28B23/00 ,  D04C1/06 ,  E04C5/07 ,  B32B7/00

CPC分类号： E04C5/07 ,  B28B23/0006 ,  B28B3/2645 ,  D04C1/06 ,  Y10T428/2915

摘要： A reinforcing structural material is provided made of a plurality of fiber assembly cords interwoven into a braid, each of the cords being comprised of a plurality of fibers, and the braids being impregnated with a bonding agent for bonding together the fibers and cords. The reinforcing braid is useful for reinforcing a fibrous inorganic composite providing a product which is light in weight but excellent in strength characteristics.

摘要翻译： 提供由多个交织成编织物的纤维组合帘线制成的增强结构材料，每个帘线由多根纤维组成，并且该编织层浸渍有用于将纤维和帘线粘合在一起的粘合剂。 增强编织物可用于增强提供重量轻但强度特性优异的产品的纤维无机复合材料。

公开(公告)号：US20170101466A1

公开(公告)日：2017-04-13

申请号：US15315851

申请日：2015-06-01

申请人： Masahisa Handa ,  Robert Fick ,  Dongxing Zha

发明人： Masahisa Handa ,  Robert Fick ,  Dongxing Zha

IPC分类号： C07K16/24 ,  A61K39/395 ,  C12N15/81 ,  A61K45/06

CPC分类号： C07K16/241 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4706 ,  A61K31/603 ,  A61K31/616 ,  A61K31/69 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2875 ,  C07K2317/10 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/815 ,  A61K2300/00

摘要： The present invention provides antibodies and antigen-binding fragments thereof that bind specifically to BlyS, immunoglobulin chains thereof, variants thereof; and method of use thereof, e.g., for the treatment or prevention of inflammatory and/or immune diseases such as systemic lupus erythramatous; as well as polynucleotides encoding the immunoglobulin chains of such antibodies and fragments. Methods for the recombinant expression of immunoglobulin chains are also part of the present invention.

公开(公告)号：US08586716B2

公开(公告)日：2013-11-19

申请号：US11833726

申请日：2007-08-03

申请人： Jeff Hsu ,  Linda Masat ,  Judy Abraham ,  Masahisa Handa ,  Siew Schleyer

发明人： Jeff Hsu ,  Linda Masat ,  Judy Abraham ,  Masahisa Handa ,  Siew Schleyer

IPC分类号： C07K16/30 ,  A61K39/395

CPC分类号： C07K16/30 ,  C07K16/2866 ,  C07K2317/56 ,  C07K2317/75 ,  C07K2317/77 ,  C07K2317/92

摘要： EphB3-specific antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating cancer.

公开(公告)号：US07794976B2

公开(公告)日：2010-09-14

申请号：US11831691

申请日：2007-07-31

申请人： Masahisa Handa ,  Arnold H. Horwitz ,  Robyn Cotter ,  Eddie Batista

发明人： Masahisa Handa ,  Arnold H. Horwitz ,  Robyn Cotter ,  Eddie Batista

IPC分类号： C12P21/04 ,  C12N15/00 ,  C12N5/12

CPC分类号： C07K16/00 ,  C12N7/00 ,  C12N15/85 ,  C12N2710/16221 ,  C12N2710/16243 ,  C12N2800/108 ,  C12N2820/10 ,  C12N2820/55 ,  C12N2820/60 ,  C12N2830/42

摘要： Recombinant expression vectors are provided comprising a 3′UTR of a light chain and an Epstein-Barr virus origin of replication. Also provided are host cells comprising such vectors and methods of producing recombinant protein with such vectors. Additional methods of producing a recombinant protein involve contacting cells with a first and second vector, each of which encode a different polypeptide chain, and wherein the second vector is present in an amount which is about 1.5 to 2.5 times as much as that of the first vector. Cells also can be transfected with a recombinant transient expression vector encoding a protein and are cultured in a medium in a membrane-enhanced culturing vessel to produce recombinant protein.

摘要翻译： 提供重组表达载体，其包含轻链的3'UTR和Epstein-Barr病毒复制起点。 还提供了包含这种载体的宿主细胞和用这种载体产生重组蛋白的方法。 生产重组蛋白质的其它方法包括使细胞与第一和第二载体接触，第一和第二载体各自编码不同的多肽链，其中第二载体的存在量为第一载体的约1.5至2.5倍 向量。 细胞也可以用编码蛋白质的重组瞬时表达载体转染，并在膜增强培养容器中的培养基中培养以产生重组蛋白。