公开(公告)号：US06605644B2

公开(公告)日：2003-08-12

申请号：US10002249

申请日：2001-10-26

申请人： Marc Kamin ,  William Olson

发明人： Marc Kamin ,  William Olson

IPC分类号： A61K31135

CPC分类号： A61K31/135

摘要： A regimen for the administration of tramadol for the treatment of analgesia is described. The regimen involves a slower initial titration rate of tramadol which results in a significantly lower percentage of discontinuations of therapy due to a lower incidence and severity of side effects.

公开(公告)号：US06339105B1

公开(公告)日：2002-01-15

申请号：US09415753

申请日：1999-10-12

申请人： Marc Kamin ,  William Olson

发明人： Marc Kamin ,  William Olson

IPC分类号： A61K31135

CPC分类号： A61K31/135

摘要： A regimen for the administration of tramadol for the treatment of analgesia is described. The regimen involves a slower initial titration rate of tramadol which results in a significantly lower percentage of discontinuations of therapy due to a lower incidence and severity of side effects.

摘要翻译： 描述了用于治疗镇痛剂的曲马多的给药方案。 该方案涉及曲马多的较慢的初始滴定速率，这导致治疗中断的百分比显着降低，因为副作用的发生率和严重程度较低。