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1.发明授权Fully implantable nerve signal sensing and stimulation device and method for treating foot drop and other neurological disorders 有权完全植入式神经信号感知和刺激装置及治疗脚痛等神经系统疾病的方法公开(公告)号：US07636602B2
公开(公告)日：2009-12-22
申请号：US10817158
申请日：2004-04-02
申请人： Marcelo Daniel Baru Fassio , Joaquin Andres Hoffer , Enric Calderon , Gary Bernhard Jenne , Albert Calderon
发明人： Marcelo Daniel Baru Fassio , Joaquin Andres Hoffer , Enric Calderon , Gary Bernhard Jenne , Albert Calderon
IPC分类号： A61N1/00
CPC分类号： A61B5/112 , A61B5/7207 , A61N1/0556 , A61N1/36003 , A61N1/36067
摘要： A fully implantable nerve stimulation system includes an event-triggered, closed-loop control unit that detects physiological events from nerve signals and delivers stimulation pulses to a nerve to produce a desired physiological response. The stimulation system includes a low-noise, low-power nerve signal amplifier, accelerometers that detect position and a battery powered processor that selectively powers components in the system to detect physiological events and deliver stimulation pulses with a minimum of battery power.
摘要翻译： 完全可植入的神经刺激系统包括事件触发的闭环控制单元，其检测来自神经信号的生理事件并将刺激脉冲传递给神经以产生期望的生理反应。 刺激系统包括低噪声，低功率神经信号放大器，检测位置的加速度计和电池供电的处理器，其选择性地为系统中的组件供电，以检测生理事件并以最小的电池电力递送刺激脉冲。
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2.发明授权公开(公告)号：US08086305B2
公开(公告)日：2011-12-27
申请号：US11315884
申请日：2005-12-21
CPC分类号： A61B5/04001
摘要： An implantable microvolt-level signal amplifying circuit may be used for resolving electrical signals generated by nerves in the presence of larger amplitude signals generated by muscles, the heart, or external noise sources. The circuit has a low-noise, high Common Mode Rejection Ratio (CMRR) preamplifier, followed by a cascade of stages, which provide filtering and further amplification of the neural signal. The band-pass amplifying circuit can also present high Power Supply Rejection Ratio (PSRR). The output is offset-compensated by a DC restoration stage. Nerve protection circuitry minimizes or blocks DC current flow through the input terminals in the event of semiconductor failure in the preamplifier. The circuit may be incorporated onto a common monolithic circuit with follow-up circuitry for controlling Functional Electrical Stimulation (FES) devices.
摘要翻译： 在由肌肉，心脏或外部噪声源产生的较大振幅信号的存在下，可植入微电平信号放大电路可用于分辨由神经产生的电信号。 该电路具有低噪声，高共模抑制比（CMRR）前置放大器，其次是级联级，提供了神经信号的滤波和进一步放大。 带通放大电路还可以提供高电源抑制比（PSRR）。 输出由直流恢复级补偿。 在前置放大器发生半导体故障的情况下，神经保护电路可以最大限度地减少或阻止通过输入端子的直流电流。 电路可以并入到具有用于控制功能电刺激（FES）装置的后续电路的公共单片电路上。
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公开(公告)号：US06996435B2
公开(公告)日：2006-02-07
申请号：US09988112
申请日：2001-11-19
IPC分类号： A61B5/00
CPC分类号： A61B5/04001
摘要： An implantable microvolt-level signal amplifying circuit may be used for resolving electrical signals generated by nerves in the presence of larger amplitude signals generated by muscles, the heart, or external noise sources. The circuit has a low-noise, high Common Mode Rejection Ratio (CMRR) preamplifier, followed by a cascade of stages, which provide filtering and further amplification of the neural signal. The band-pass amplifying circuit can also present high Power Supply Rejection Ratio (PSRR). The output is offset-compensated by a DC restoration stage. Nerve protection circuitry minimizes or blocks DC current flow through the input terminals in the event of semiconductor failure in the preamplifier. The circuit may be incorporated onto a common monolithic circuit with follow-up circuitry for controlling Functional Electrical Stimulation (FES) devices.
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