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1.发明授权Nucleic acid for plant expression of a fusion protein comprising hydroxyproline O-glycosylation glycomodule 有权用于植物表达包含羟脯氨酸O-糖基化糖基化的融合蛋白的核酸公开(公告)号：US09006410B2
公开(公告)日：2015-04-14
申请号：US13019819
申请日：2011-02-02
IPC分类号： C12N15/82 , C12N15/18 , C12N15/20 , C12N15/62 , C07H21/04 , C07K14/415 , C07K14/61 , C07K14/765 , C12P21/00 , C07K14/56 , A61K38/21 , A61K38/27
CPC分类号： C07K14/415 , A61K38/27 , C07K14/56 , C07K14/61 , C07K14/765 , C12N15/62 , C12N15/8257 , C12P21/005
摘要： Methods of increasing the yield in plant expression of recombinant proteins comprising engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion are present. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are also present.
摘要翻译： 包括使用驱动植物中翻译后修饰的密码子的蛋白质工程化糖基化位点的重组蛋白质的植物表达产量增加到克隆基因或cDNA的方法，并且设计克隆的基因或cDNA以包含靶向基因的植物分泌信号序列 存在用于分泌的产品（蛋白质）。 该方法导致重组糖基化蛋白质产量增加。 也存在根据这些方法生产的蛋白质。
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2.发明授权Synthetic genes for plant gums and other hydroxyproline rich glycoproteins 失效植物牙龈和其他富含羟脯氨酸的糖蛋白的合成基因公开(公告)号：US08563687B2
公开(公告)日：2013-10-22
申请号：US12820943
申请日：2010-06-22
CPC分类号： C07K14/415 , C07K2319/00 , C12N15/8241 , C12N15/8242
摘要： A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabino-galactan proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells.
摘要翻译： 描述了植物胶领域的新方法，其提供了生产富含羟脯氨酸（Hyp）的糖蛋白（HRGP），重复的富含脯氨酸蛋白（RPRP）和阿拉伯半乳聚糖蛋白（AGP）的新解决方案。 在宿主细胞（包括植物宿主细胞）中教导了由这种糖蛋白的重复肽序列（包括阿拉伯糖糖蛋白（GAGP）的肽序列）设计的合成基因的表达。
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公开(公告)号：US20110230404A1
公开(公告)日：2011-09-22
申请号：US13005715
申请日：2011-01-13
CPC分类号： C07K14/415 , A61K38/27 , C07K14/56 , C07K14/61 , C07K14/765 , C12N15/62 , C12N15/8257 , C12P21/005
摘要： Methods of increasing the yield in plant expression of recombinant proteins comprising engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants; and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are disclosed.
摘要翻译： 包括使用驱动植物翻译后修饰的密码子将包含工程化糖基化位点的重组蛋白质的产量提高到克隆基因或蛋白质cDNA的方法; 并对克隆的基因或cDNA进行工程以包含靶向分泌基因产物（蛋白质）的植物分泌信号序列。 该方法导致重组糖基化蛋白质产量增加。 公开了根据这些方法生产的蛋白质。
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4.发明申请公开(公告)号：US20140287457A9
公开(公告)日：2014-09-25
申请号：US13149016
申请日：2011-05-31
CPC分类号： C07K14/415 , C07K2319/00 , C12N15/8241 , C12N15/8242
摘要： A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells.
摘要翻译： 描述了植物胶领域的新方法，其提供了生产富含羟脯氨酸（Hyp）的糖蛋白（HRGP），重复的富含脯氨酸蛋白（RPRP）和阿拉伯半乳聚糖蛋白（AGP）的新解决方案。 在宿主细胞（包括植物宿主细胞）中教导了由这种糖蛋白的重复肽序列（包括阿拉伯糖糖蛋白（GAGP）的肽序列）设计的合成基因的表达。
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5.发明申请公开(公告)号：US20100261874A1
公开(公告)日：2010-10-14
申请号：US12820943
申请日：2010-06-22
CPC分类号： C07K14/415 , C07K2319/00 , C12N15/8241 , C12N15/8242
摘要： A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabino-galactan proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAUP), is taught in host cells, including plant host cells.
摘要翻译： 描述了植物胶领域的新方法，其提供了生产富含羟脯氨酸（Hyp）的糖蛋白（HRGP），重复的富含脯氨酸蛋白（RPRP）和阿拉伯半乳聚糖蛋白（AGP）的新解决方案。 在宿主细胞（包括植物宿主细胞）中教导了由这种糖蛋白的重复肽序列（包括阿拉伯糖糖蛋白（GAUP）的肽序列）设计的合成基因的表达。
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公开(公告)号：US06548642B1
公开(公告)日：2003-04-15
申请号：US09119507
申请日：1998-07-20
IPC分类号： C07K700
CPC分类号： C12N15/8241 , C07K14/415 , C07K2319/00 , C12N15/8242
摘要： A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabino-galactan proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells.
摘要翻译： 描述了植物胶领域的新方法，其提供了生产富含羟脯氨酸（Hyp）的糖蛋白（HRGP），重复的富含脯氨酸蛋白（RPRP）和阿拉伯半乳聚糖蛋白（AGP）的新解决方案。 在宿主细胞（包括植物宿主细胞）中教导了由这种糖蛋白的重复肽序列（包括阿拉伯糖糖蛋白（GAGP）的肽序列）设计的合成基因的表达。
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7.发明授权公开(公告)号：US08871468B2
公开(公告)日：2014-10-28
申请号：US13149016
申请日：2011-05-31
IPC分类号： C07K14/415 , C12P21/02 , C07H21/04 , C12N15/11 , C12N15/82
CPC分类号： C07K14/415 , C07K2319/00 , C12N15/8241 , C12N15/8242
摘要： A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells.
摘要翻译： 描述了植物胶领域的新方法，其提供了生产富含羟脯氨酸（Hyp）的糖蛋白（HRGP），重复的富含脯氨酸蛋白（RPRP）和阿拉伯半乳聚糖蛋白（AGP）的新解决方案。 在宿主细胞（包括植物宿主细胞）中教导了由这种糖蛋白的重复肽序列（包括阿拉伯糖糖蛋白（GAGP）的肽序列）设计的合成基因的表达。
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公开(公告)号：US08623812B2
公开(公告)日：2014-01-07
申请号：US11568102
申请日：2005-04-19
申请人： Marcia J. Kieliszewski , Michael Held , Li Tan
发明人： Marcia J. Kieliszewski , Michael Held , Li Tan
CPC分类号： C07K14/00 , C07K14/415
摘要： Non-naturally occurring peptides/polypeptides/proteins comprising the crosslinking motif, Tyr-X-Tyr, wherein X is any amino acid, and methods of preparing the same.
摘要翻译： 包含交联基序Tyr-X-Tyr（其中X是任何氨基酸）的非天然存在的肽/多肽/蛋白质及其制备方法。
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9.发明申请公开(公告)号：US20110003340A1
公开(公告)日：2011-01-06
申请号：US12781490
申请日：2010-05-17
CPC分类号： C07K14/415 , C07K2319/00 , C12N15/8241 , C12N15/8242
摘要： A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline (Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells.
摘要翻译： 描述了植物胶领域的新方法，其提供了生产富含羟脯氨酸（Hyp）的糖蛋白（HRGP），重复的富含脯氨酸蛋白（RPRP）和阿拉伯半乳聚糖蛋白（AGP）的新解决方案。 在宿主细胞（包括植物宿主细胞）中教导了由这种糖蛋白的重复肽序列（包括阿拉伯糖糖蛋白（GAGP）的肽序列）设计的合成基因的表达。
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10.发明授权公开(公告)号：US07378506B2
公开(公告)日：2008-05-27
申请号：US10418032
申请日：2003-04-16
CPC分类号： C07K14/415 , C07K2319/00 , C12N15/8241 , C12N15/8242
摘要： A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells.
摘要翻译： 描述了植物胶领域的新方法，其提供了生产富含羟脯氨酸（Hyp）的糖蛋白（HRGP），重复的富含脯氨酸蛋白（RPRP）和阿拉伯半乳聚糖蛋白（AGP）的新解决方案。 在宿主细胞（包括植物宿主细胞）中教导了由这种糖蛋白的重复肽序列（包括阿拉伯糖糖蛋白（GAGP）的肽序列）设计的合成基因的表达。
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