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    Glycoproteins produced in plants and methods of their use
    1.
    发明申请
    Glycoproteins produced in plants and methods of their use 审中-公开
    在植物中生产的糖蛋白及其使用方法

    公开(公告)号：US20060148680A1

    公开(公告)日：2006-07-06

    申请号：US11036257

    申请日：2005-01-14

    申请人： Marcia Kieliszewski ,  Jianfeng Xu ,  John Kopchick ,  Shigeru Okada

    发明人： Marcia Kieliszewski ,  Jianfeng Xu ,  John Kopchick ,  Shigeru Okada

    IPC分类号： A61K38/27

    CPC分类号： C07K14/415 ,  A61K38/27 ,  C07K14/56 ,  C07K14/61 ,  C07K14/765 ,  C12N15/62 ,  C12N15/8257 ,  C12P21/005

    摘要： Methods of increasing the yield in plant expression of recombinant proteins comprising: engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants; and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are disclosed.

    摘要翻译： 提高重组蛋白质植物表达产量的方法，其包括：使用驱动植物翻译后修饰的密码子将糖基化位点工程化为克隆基因或蛋白质cDNA; 并对克隆的基因或cDNA进行工程以包含靶向分泌基因产物（蛋白质）的植物分泌信号序列。 该方法导致重组糖基化蛋白质产量增加。 公开了根据这些方法生产的蛋白质。

    Diagnosis of hyperinsulinemia and type II diabetes and protection against same
    4.
    发明申请
    Diagnosis of hyperinsulinemia and type II diabetes and protection against same 审中-公开
    诊断高胰岛素血症和II型糖尿病及其相关保护

    公开(公告)号：US20070142311A1

    公开(公告)日：2007-06-21

    申请号：US10552443

    申请日：2004-04-02

    申请人： John Kopchick ,  Bruce Kedler ,  Keith Boyce ,  Andres Kriete

    发明人： John Kopchick ,  Bruce Kedler ,  Keith Boyce ,  Andres Kriete

    IPC分类号： A61K31/70 ,  A01N43/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： Mouse genes differentially expressed in comparisons of normal vs. hyperinsulinemic, hyperinsulinemic vs. type 2 diabetic, and normal vs. type 2 diabetic liver by gene chip analysis have been identified, as have corresponding human genes and proteins. The human molecules, or antagonists thereof, may be used for protection against hyperinsulinemia or type 2 diabetes, or their sequelae.

    摘要翻译： 已经确定了通过基因芯片分析正常与高胰岛素血症，高胰岛素血症与2型糖尿病和正常对2型糖尿病肝脏比较差异表达的小鼠基因，具有相应的人类基因和蛋白质。 人类分子或其拮抗剂可用于防止高胰岛素血症或2型糖尿病或其后遗症。

    Diagnosis of kidney damage and protection against same
    5.
    发明申请
    Diagnosis of kidney damage and protection against same 审中-公开
    诊断肾损害和保护相同

    公开(公告)号：US20060240500A1

    公开(公告)日：2006-10-26

    申请号：US10524237

    申请日：2003-08-04

    申请人： John Kopchick ,  Karen Coschigano ,  Amy Wetzel

    发明人： John Kopchick ,  Karen Coschigano ,  Amy Wetzel

    IPC分类号： A61K48/00 ,  A61K38/54 ,  C12Q1/62

    CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/177 ,  A61K38/465 ,  A61K38/53 ,  C07K14/47 ,  G01N2800/347

    摘要： Various nucleic acids and proteins have been identified by differential hybridization methods as useful as markers for diagnosing kidney damage. The identified marker proteins include (I) androgen related protein, SON protein, FUSE binding Protein 1, claudin10, heat shock protein, phospho triesterase related protein, ubiquitin protein ligase Nedd-4, and Ac39/physophilin, and (II) disabled-2 p96, palmitylated serine/threonine kinase, tumor differentially expressed 1 protein, cytochrome oxidase III, TLH 39 protein precursor, hydroxysteroid dehydrogenase 4 delta -3 beta, and glutathione peroxidase III. The proteins of group (I), and antagonists of the proteins of group (II), are useful for protecting mammals against kidney damage.

    摘要翻译： 已经通过差异杂交方法鉴定了各种核酸和蛋白质，作为用于诊断肾损伤的标记物。 鉴定的标记蛋白包括（I）雄激素相关蛋白，SON蛋白，FUSE结合蛋白1，claudin10，热休克蛋白，磷酸三酯酶相关蛋白，泛素蛋白连接酶Nedd-4和Ac39 / physophilin，和（II）残基-2 p96，棕榈酰丝氨酸/苏氨酸激酶，肿瘤差异表达1蛋白，细胞色素氧化酶III，TLH 39蛋白前体，羟基类固醇脱氢酶4Δ5β-3β和谷胱甘肽过氧化物酶III。 组（I）的蛋白质和组（II）的蛋白质的拮抗剂可用于保护哺乳动物免受肾损伤。

    Diagnosis and treatment methods related to aging, especially of liver
    6.
    发明申请
    Diagnosis and treatment methods related to aging, especially of liver 审中-公开
    与老化有关的诊断和治疗方法，特别是肝脏

    公开(公告)号：US20070111933A1

    公开(公告)日：2007-05-17

    申请号：US10558877

    申请日：2004-06-02

    申请人： John Kopchick ,  Bruce Kelder ,  Keith Boyce ,  Andres Kriete

    发明人： John Kopchick ,  Bruce Kelder ,  Keith Boyce ,  Andres Kriete

    IPC分类号： A61K38/17 ,  A61K48/00

    CPC分类号： C12Q1/6883 ,  A61K38/1709 ,  A61K48/00 ,  C12Q2600/158

    摘要： Mouse genes differentially expressed in comparisons of older and younger livers by gene chip analysis have been identified, as have corresponding human genes and proteins. The human molecules, or antagonists thereof, may be used for protection against faster-than-normal biological aging, or to achieve slower-than-normal biological aging. The human molecules may also be used as markers of biological aging.

    摘要翻译： 已经鉴定了通过基因芯片分析比较老年和较年轻肝脏差异表达的小鼠基因，具有相应的人类基因和蛋白质。 人类分子或其拮抗剂可以用于防止比正常生物老化更快的保护，或者达到比正常的生物衰老慢。 人类分子也可以用作生物衰老的标记物。