公开(公告)号：US20210380670A1

公开(公告)日：2021-12-09

申请号：US17402329

申请日：2021-08-13

申请人： Marengo Therapeutics, Inc.

发明人： Andreas Loew ,  Ilaria Lamberto ,  Seng-Lai Tan ,  Jonathan Hsu ,  Brian Edward Vash ,  Nidhi Malhotra ,  Madan Katragadda ,  John Leonard Herrmann ,  Stephanie J. Maiocco

IPC分类号： C07K16/18 ,  C07K16/28 ,  A61K39/395 ,  A61P35/00

摘要： Multifunctional molecules that include i) an antigen binding domain that binds to a calreticulin protein; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.