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公开(公告)号：US20240002543A1
公开(公告)日：2024-01-04
申请号：US18173995
申请日：2023-02-24
CPC分类号： C07K16/468 , A61P35/00 , C07K2317/52 , C07K2317/565 , C07K2317/31
摘要： Multifunctional molecules that include i) an antigen binding domain that binds to a calreticulin protein; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.
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公开(公告)号：US20230227552A1
公开(公告)日：2023-07-20
申请号：US17855332
申请日：2022-06-30
发明人： Seng-Lai Tan , Brian Edward Vash , Jonathan Hsu , Dilini Charmain Gunasekera , Sangeetha Sagar Palakurthi , Andreas Loew , Madan Katragadda , Peter Marek , Gurkan Guntas
CPC分类号： C07K16/2809 , A61P37/04 , A61P35/00 , C07K2317/565 , C07K2317/52
摘要： The disclosure provides antibody molecules that bind to TCR VP regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.
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公开(公告)号：US20210380670A1
公开(公告)日：2021-12-09
申请号：US17402329
申请日：2021-08-13
发明人： Andreas Loew , Ilaria Lamberto , Seng-Lai Tan , Jonathan Hsu , Brian Edward Vash , Nidhi Malhotra , Madan Katragadda , John Leonard Herrmann , Stephanie J. Maiocco
IPC分类号： C07K16/18 , C07K16/28 , A61K39/395 , A61P35/00
摘要： Multifunctional molecules that include i) an antigen binding domain that binds to a calreticulin protein; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.
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公开(公告)号：US11845797B2
公开(公告)日：2023-12-19
申请号：US17256917
申请日：2019-07-03
发明人： Seng-Lai Tan , Brian Edward Vash , Jonathan Hsu , Dilini Charmain Gunasekera , Sangeetha Sagar Palakurthi , Andreas Loew
CPC分类号： C07K16/2809 , A61K35/17 , A61P35/00 , C07K16/2803 , C07K16/283 , C07K16/2878 , C12N5/0634 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/92
摘要： The disclosure provides antibody molecules that bind to TCR Vβ regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.
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公开(公告)号：US20230357395A1
公开(公告)日：2023-11-09
申请号：US18048614
申请日：2022-10-21
发明人： Andreas Loew , Nidhi Malhotra , Madan Katragadda , Peter Marek , Gurkan Guntas , Sangeetha Palakurthi
CPC分类号： C07K16/2809 , A61P35/00 , C07K16/2803 , C12N15/85 , A61K39/00 , C07K2317/24 , C07K2317/31 , C07K2317/565
摘要： Multifunctional molecules that include i) an antigen binding domain that binds to a T cell receptor beta chain constant domain 1 or T cell receptor beta chain constant domain 2; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or cytokine inhibitor molecule; (iv) a death receptor signal enhancer; and/or (v) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.
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公开(公告)号：US20230348593A1
公开(公告)日：2023-11-02
申请号：US18172928
申请日：2023-02-22
发明人： Andreas Loew , Madan Katragadda , Andrea Tiffany
CPC分类号： C07K16/2803 , C07K14/54 , C07K14/5418 , C07K14/5434 , C07K14/5443 , C07K2317/31 , C07K2319/30
摘要： Antibody molecules that specifically bind to NKp30 are disclosed. The anti-NKp30 antibody molecules can be used to treat, prevent and/or diagnose cancerous, autoimmune or infectious conditions and disorders.
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公开(公告)号：US20230272119A1
公开(公告)日：2023-08-31
申请号：US18316804
申请日：2023-05-12
CPC分类号： C07K16/468 , C07K16/00 , A61P35/00 , C07K16/246 , C07K16/2818 , C07K16/2878 , C07K16/40 , C07K16/44 , C07K2317/515 , C07K2317/31 , C07K2317/567
摘要： Multispecific, e.g., bispecific, antibody molecules that include a kappa light chain polypeptide and one lambda light chain polypeptide, and methods of making and using the multispecific antibody molecules, are disclosed.
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公开(公告)号：US20220288200A1
公开(公告)日：2022-09-15
申请号：US17584892
申请日：2022-01-26
发明人： Andreas LOEW , Brian Edward Vash
IPC分类号： A61K39/395 , C07K16/30 , C07K16/28 , C07K16/40 , C07K16/32 , C07K14/55 , C07K14/71 , C07K14/705 , C07K14/47 , A61K39/00 , A61K38/17
摘要： Multispecific molecules that include i) a tumor-targeting moiety; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.
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公开(公告)号：US20210380692A1
公开(公告)日：2021-12-09
申请号：US17402322
申请日：2021-08-13
发明人： Andreas Loew , Seng-Lai Tan , Jonathan Hsu , Brian Edward Vash
IPC分类号： C07K16/28 , G01N33/68 , A61K35/17 , C12N5/0783
摘要： The disclosure provides antibody molecules that bind to TCR Vβ regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating an infectious disease using the aforesaid molecules.
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公开(公告)号：US20210380682A1
公开(公告)日：2021-12-09
申请号：US17402325
申请日：2021-08-13
发明人： Andreas Loew , Nidhi Malhotra , Madan Katragadda , Seng-Lai Tan , Jonathan Hsu , Brian Edward Vash , Stephanie J. Maiocco , Peter Marek , Gurkan Guntas
摘要： Multifunctional molecules that include i) an antigen binding domain that binds to a T cell receptor beta chain constant domain 1 or T cell receptor beta chain constant domain 2; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or cytokine inhibitor molecule; (iv) a death receptor signal enhancer; and/or (v) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.
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