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1.发明申请TRISUBSTITUTED 3,4-DIHYDRO-1H-ISOQUINOLIN COMPOUND, PROCESS FOR ITS PREPARATION, AND ITS USE 有权三取代3,4-二氢-1H-异喹啉化合物，其制备方法及其用途公开(公告)号：US20100010226A1
公开(公告)日：2010-01-14
申请号：US12497023
申请日：2009-07-02
申请人： Maria Andreas Hendrikus De Vries , Doris Domin , Matthias Helms , Chistoph Imboden , Ralph Koberstein , Zarghun Nazir , Wolfgang Skranc , Michael Stanek , Wilhelm Tschebull , Maria Gerardus Karel Verzijl , Jürgen Stichler
发明人： Maria Andreas Hendrikus De Vries , Doris Domin , Matthias Helms , Chistoph Imboden , Ralph Koberstein , Zarghun Nazir , Wolfgang Skranc , Michael Stanek , Wilhelm Tschebull , Maria Gerardus Karel Verzijl , Jürgen Stichler
IPC分类号： C07D217/12
CPC分类号： C07D217/18
摘要： The present invention relates to the compound of formula 7*acetate (see below), a process for its preparation, and its use
摘要翻译： 本发明涉及式7 *乙酸酯化合物（见下文），其制备方法及其用途
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2.发明授权Trisubstituted 3,4-dihydro-1H-isoquinolin compound, process for its preparation, and its use 有权三取代的3,4-二氢-1H-异喹啉化合物，其制备方法及其用途公开(公告)号：US08247560B2
公开(公告)日：2012-08-21
申请号：US12497023
申请日：2009-07-02
申请人： Maria Andreas Hendrikus De Vries , Doris Domin , Matthias Helms , Christoph Imboden , Ralph Koberstein , Zarghun Nazir , Wolfgang Skranc , Michael Stanek , Wilhelm Tschebull , Maria Gerardus Karel Verzijl , Jurgen Stichler
发明人： Maria Andreas Hendrikus De Vries , Doris Domin , Matthias Helms , Christoph Imboden , Ralph Koberstein , Zarghun Nazir , Wolfgang Skranc , Michael Stanek , Wilhelm Tschebull , Maria Gerardus Karel Verzijl , Jurgen Stichler
IPC分类号： C07D217/20
CPC分类号： C07D217/18
摘要： The present invention relates to the compound of formula 7*acetate (see below), a process for its preparation, and its use
摘要翻译： 本发明涉及式7 *乙酸酯化合物（见下文），其制备方法及其应用
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3.发明申请公开(公告)号：US20100305325A1
公开(公告)日：2010-12-02
申请号：US12810176
申请日：2008-12-23
申请人： Erhard Bappert , Andreas Hendrikus Maria De Vries , Doris Domin , Matthias Helms , Christoph Imboden , Zarghun Nazir , Wolfgang Skranc , Felix Spindler , Michael Stanek , Wilhelm Tschebull , Gerardus Karel Maria Verzijl
发明人： Erhard Bappert , Andreas Hendrikus Maria De Vries , Doris Domin , Matthias Helms , Christoph Imboden , Zarghun Nazir , Wolfgang Skranc , Felix Spindler , Michael Stanek , Wilhelm Tschebull , Gerardus Karel Maria Verzijl
IPC分类号： C07D217/20
CPC分类号： C07D217/02
摘要： The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst.
摘要翻译： 本发明涉及制备式（7）化合物的方法，该方法包括使用双[氯-1,5-环辛二烯 - 铱]，（S）-i 二环己基膦基-2 - [（S）-α-（二甲基氨基）-2-（二环己基膦基）苄基] - 二茂铁作为催化剂。
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4.发明授权Process for the preparation of an enantiomeric trisubstituted 3,4-dihydro-isoquinoline derivative 有权制备对映体三取代3,4-二氢异喹啉衍生物的方法公开(公告)号：US08314238B2
公开(公告)日：2012-11-20
申请号：US12810176
申请日：2008-12-23
申请人： Erhard Bappert , Andreas Hendrikus Maria De Vries , Doris Domin , Matthias Helms , Christoph Imboden , Zarghun Nazir , Wolfgang Skranc , Felix Spindler , Michael Stanek , Wilhelm Tschebull , Gerardus Karel Maria Verzijl
发明人： Erhard Bappert , Andreas Hendrikus Maria De Vries , Doris Domin , Matthias Helms , Christoph Imboden , Zarghun Nazir , Wolfgang Skranc , Felix Spindler , Michael Stanek , Wilhelm Tschebull , Gerardus Karel Maria Verzijl
IPC分类号： C07D217/20 , A61K31/47
CPC分类号： C07D217/02
摘要： The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst.
摘要翻译： 本发明涉及制备式（7）化合物的方法，该方法包括使用双[氯-1,5-环辛二烯 - 铱]，（S）-i 二环己基膦基-2 - [（S）-α-（二甲基氨基）-2-（二环己基膦基）苄基] - 二茂铁作为催化剂。
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