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公开(公告)号：US08183216B2
公开(公告)日：2012-05-22
申请号：US12679713
申请日：2008-09-16
IPC分类号： A01N43/04 , A61K31/70 , C07H19/00 , C07H19/056
CPC分类号： C07H19/23
摘要： A class of nucleoside derivatives of formula (I), as defined herein, that are useful as inhibitors of RNA-dependent RNA viral replication and in particular HCV replication, are provided. Also provided are processes for the synthesis and use of such compounds for treating or preventing HCV infection. formula (I).
摘要翻译： 提供了一类本文定义的式（I）核苷衍生物，其可用作RNA依赖性RNA病毒复制的抑制剂，特别是HCV复制。 还提供了用于合成和使用这些化合物治疗或预防HCV感染的方法。 式（I）。
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公开(公告)号：US20100210581A1
公开(公告)日：2010-08-19
申请号：US12679713
申请日：2008-09-16
IPC分类号： A61K31/7064 , C07H19/23 , A61P31/12
CPC分类号： C07H19/23
摘要： A class of nucleoside derivatives of formula (I), as defined herein, that are useful as inhibitors of RNA-dependent RNA viral replication and in particular HCV replication, are provided. Also provided are processes for the synthesis and use of such compounds for treating or preventing HCV infection.
摘要翻译： 提供了一类本文定义的式（I）核苷衍生物，其可用作RNA依赖性RNA病毒复制的抑制剂，特别是HCV复制。 还提供了用于合成和使用这些化合物治疗或预防HCV感染的方法。
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公开(公告)号：US20100261709A1
公开(公告)日：2010-10-14
申请号：US12739262
申请日：2008-11-14
申请人： Danila Branca , Gabriella Dessole , Federica Ferrigno , Philip Jones , Olaf Kinzel , Samuele Lillini , Ester Muraglia , Giovanna Pescatore , Carsten Schultz-Fademrecht
发明人： Danila Branca , Gabriella Dessole , Federica Ferrigno , Philip Jones , Olaf Kinzel , Samuele Lillini , Ester Muraglia , Giovanna Pescatore , Carsten Schultz-Fademrecht
IPC分类号： A61K31/551 , C07D403/10 , A61K31/501 , C07D243/08 , A61P35/00 , A61P29/00 , A61P9/00 , A61P13/12 , A61P31/00 , A61P3/10 , A61P17/16 , A61P25/00
CPC分类号： C07D403/10
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinaldamage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐或互变异构体，其是聚（ADP-核糖）聚合酶（PARP）的抑制剂，因此可用于治疗癌症，炎性疾病，再灌注损伤，缺血性疾病 ，中风，肾衰竭，心血管疾病，心血管疾病以外的血管疾病，糖尿病，神经变性疾病，逆转录病毒感染，视网膜损伤，皮肤衰老和UV诱导的皮肤损伤，以及用于癌症治疗的化学或放射增敏剂。
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公开(公告)号：US08268827B2
公开(公告)日：2012-09-18
申请号：US12739262
申请日：2008-11-14
申请人： Danila Branca , Gabriella Dessole , Federica Ferrigno , Philip Jones , Olaf Kinzel , Samuele Lillini , Ester Muraglia , Giovanna Pescatore , Carsten Schultz-Fademrecht
发明人： Danila Branca , Gabriella Dessole , Federica Ferrigno , Philip Jones , Olaf Kinzel , Samuele Lillini , Ester Muraglia , Giovanna Pescatore , Carsten Schultz-Fademrecht
IPC分类号： C07D401/00 , A60K31/50
CPC分类号： C07D403/10
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐或互变异构体，其是聚（ADP-核糖）聚合酶（PARP）的抑制剂，因此可用于治疗癌症，炎性疾病，再灌注损伤，缺血性疾病 ，中风，肾衰竭，心血管疾病，心血管疾病以外的血管疾病，糖尿病，神经变性疾病，逆转录病毒感染，视网膜损伤，皮肤衰老和紫外线诱发的皮肤损伤，以及用于癌症治疗的化学或放射增敏剂。
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5.发明申请1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS 审中-公开作为SMO拮抗剂的1,2,4-OXADIAZOLE替代哌啶和哌嗪衍生物公开(公告)号：US20110183974A1
公开(公告)日：2011-07-28
申请号：US13056027
申请日：2009-07-27
申请人： Gabriella Dessole , Philip Jones , Laura Llauger Bufi , Ester Muraglia , Jesus Maria Ontoria Ontoria , Caterina Torrisi
发明人： Gabriella Dessole , Philip Jones , Laura Llauger Bufi , Ester Muraglia , Jesus Maria Ontoria Ontoria , Caterina Torrisi
IPC分类号： A61K31/5355 , C07D413/14 , A61K31/4709 , A61P35/00 , A61K31/4545 , A61K31/454 , A61K31/496
CPC分类号： C07D413/14 , C07D417/14
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smo antagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
摘要翻译： 本发明涉及式（I）的化合物及其药学上可接受的盐，立体异构体或互变异构体，其是Sonic Hedgehog途径的抑制剂，特别是Smo拮抗剂。 因此，本发明的化合物可用于治疗与异常hedgehog途径活化相关的疾病，包括癌症，例如基底细胞癌，成神经管细胞瘤，前列腺，胰腺癌，乳腺癌，结肠癌，骨细胞和小细胞肺癌，以及癌症 上胃肠道
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