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    Steriod lotion formulation
    1.
    发明授权
    Steriod lotion formulation 失效
    Steriod洗剂配方

    公开(公告)号：US4868170A

    公开(公告)日：1989-09-19

    申请号：US120277

    申请日：1987-11-13

    申请人： Marilia M. Faustino ,  Sailesh A. Varia ,  Abu T. M. Serajuddin

    发明人： Marilia M. Faustino ,  Sailesh A. Varia ,  Abu T. M. Serajuddin

    IPC分类号： A61K9/00 ,  A61K31/565 ,  A61K47/00 ,  A61K47/10

    CPC分类号： A61K9/0014 ,  A61K31/565 ,  A61K47/10

    摘要： A steroid lotion formulation which has enhanced physical and chemical stability is formed of (11.beta.,17.alpha.)-17-(ethylthio)-9.alpha.-fluoro-11.beta.-hydroxy-17-(methylthio)androsta-1,4-diene-3-one (tipredane), and a vehicle containing as major ingredients polyethylene glycol, propylene glycol and water together with a potassium citrate buffer or tromethamine buffer, and sodium metabisulfite and butylated hydroxytoluene as antioxidants.

    摘要翻译： 具有增强的物理和化学稳定性的类固醇洗剂制剂由（11β，17α）-17-（乙硫基）-9α-氟-11β-羟基-17-（甲硫基）雄甾-1,4-二烯 -3-one（tipredane）和含有柠檬酸钾缓冲液或氨丁三醇缓冲液的主要成分聚乙二醇，丙二醇和水以及偏亚硫酸氢钠和丁基化羟基甲苯作为抗氧化剂的载体。

    Pharmaceutical compositions having good dissolution properties
    2.
    发明授权
    Pharmaceutical compositions having good dissolution properties 失效
    具有良好溶出性能的药物组合物

    公开(公告)号：US5506248A

    公开(公告)日：1996-04-09

    申请号：US445623

    申请日：1995-05-22

    申请人： Faranak Nikfar ,  Abu T. M. Serajuddin ,  Robert L. Jerzewski ,  Nemichand B. Jain

    发明人： Faranak Nikfar ,  Abu T. M. Serajuddin ,  Robert L. Jerzewski ,  Nemichand B. Jain

    IPC分类号： A61K9/20 ,  A61K9/48 ,  A61K31/42 ,  A61K47/02

    CPC分类号： A61K31/42 ,  A61K47/02 ,  A61K9/2009 ,  A61K9/485

    摘要： An ifetroban composition is provided which has good dissolution properties even on aging, when dispersed in water has a pH of at least 7 and includes a salt of ifetroban, one or more basifying agents, such as magnesium oxide or calcium carbonate, and where in tablet form includes one or more fillers such as mannitol and/or microcrystalline cellulose, one or more disintegrating agents such as crospovidone, one or more lubricants such as magnesium stearate, optionally one or more glidants such as colloidal silicon dioxide, one or more binders such as pregelatinized starch (dry binder) or polyvinyl-pyrrolidone (wet binder) and optionally a film coating containing a film former such as hydroxypropyl cellulose and a plasticizer such as 1,2,3-propanetriol triacetate.

    摘要翻译： 提供即使在老化时也具有良好的溶解性的ifetroban组合物，当分散在水中时，其pH至少为7，并且包括ifetroban的盐，一种或多种碱化剂如氧化镁或碳酸钙，并且其中在片剂 形式包括一种或多种填充剂如甘露醇和/或微晶纤维素，一种或多种崩解剂，例如交聚维酮，一种或多种润滑剂，例如硬脂酸镁，任选的一种或多种助流剂，例如胶体二氧化硅，一种或多种粘合剂，例如 预胶化淀粉（干粘合剂）或聚乙烯吡咯烷酮（湿粘合剂）和任选的含有成膜剂如羟丙基纤维素和增塑剂如1,2,3-丙三醇三乙酸酯的膜包衣。