公开(公告)号：US20160206739A1

公开(公告)日：2016-07-21

申请号：US15089568

申请日：2016-04-03

Applicant: Marina Biotech, Inc.

Inventor： Steven C. Quay ,  Michael E. Houston, JR. ,  Pierrot Harvie ,  Roger C. Adami ,  Renata Fam ,  Mary Prieve ,  Kathy Fosnaugh ,  Shaguna Seth

IPC: A61K47/18 ,  C12N15/113 ,  A61K47/28 ,  C07D213/56 ,  A61K47/22 ,  A61K9/127 ,  C07C279/12

CPC classification number: A61K47/183 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/7088 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  A61K47/44 ,  A61K48/0025 ,  A61K48/0033 ,  C07C235/02 ,  C07C279/12 ,  C07C279/14 ,  C07D213/40 ,  C07D213/56 ,  C07D233/26 ,  C07D233/64 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/1138 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  Y10S514/943

Abstract: This disclosure provides a range of tyrosine amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

Abstract translation: 本公开提供了一系列可用于药物递送，治疗和疾病和病症的诊断和治疗的酪氨酸氨基酸脂质化合物和组合物。 氨基酸脂质化合物和组合物可用于向细胞，组织，器官和受试者递送各种试剂，例如核酸治疗剂。

公开(公告)号：US09731016B2

公开(公告)日：2017-08-15

申请号：US15089568

申请日：2016-04-03

Applicant: Marina Biotech, Inc.

Inventor： Steven C. Quay ,  Michael E. Houston, Jr. ,  Pierrot Harvie ,  Roger C. Adami ,  Renata Fam ,  Mary Prieve ,  Kathy Fosnaugh ,  Shaguna Seth

IPC: A61K47/18 ,  A61K48/00 ,  C07C235/02 ,  C12N15/88 ,  C07D213/56 ,  C07C279/14 ,  C07D213/40 ,  C07D233/26 ,  C12N15/11 ,  A61K47/44 ,  C12N15/113 ,  A61K31/7088 ,  A61K47/22 ,  C07D233/64 ,  A61K47/28 ,  C07C279/12 ,  A61K9/127

CPC classification number: A61K47/183 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/7088 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  A61K47/44 ,  A61K48/0025 ,  A61K48/0033 ,  C07C235/02 ,  C07C279/12 ,  C07C279/14 ,  C07D213/40 ,  C07D213/56 ,  C07D233/26 ,  C07D233/64 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/1138 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  Y10S514/943

Abstract: This disclosure provides a range of tyrosine amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

公开(公告)号：US20180353607A1

公开(公告)日：2018-12-13

申请号：US15675983

申请日：2017-08-14

Applicant: Marina Biotech, Inc.

Inventor： Steven C. Quay ,  Michael E. Houston, Jr. ,  Pierrot Harvie ,  Roger C. Adami ,  Renata Fam ,  Mary Prieve ,  Kathy Fosnaugh ,  Shaguna Seth

IPC: A61K38/16 ,  C07D233/64 ,  C07D213/56 ,  A61K47/18 ,  A61K31/7088 ,  C12N15/113 ,  A61K47/28 ,  C07C279/12 ,  A61K47/44 ,  A61K9/127 ,  C12N15/88 ,  C12N15/11 ,  C07D233/26 ,  C07D213/40 ,  C07C279/14 ,  A61K48/00 ,  C07C235/02 ,  A61K47/22

CPC classification number: A61K47/183 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/7088 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  A61K47/44 ,  A61K48/0025 ,  A61K48/0033 ,  C07C235/02 ,  C07C279/12 ,  C07C279/14 ,  C07D213/40 ,  C07D213/56 ,  C07D233/26 ,  C07D233/64 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/1138 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  Y10S514/943

Abstract: This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.