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公开(公告)号:US08946226B2
公开(公告)日:2015-02-03
申请号:US13055533
申请日:2009-07-28
IPC分类号: A61K45/06 , A61K31/4188 , A61K31/519
CPC分类号: A61K31/519 , A61K31/4188 , A61K45/06 , A61K2300/00
摘要: The invention provides a low molecular weight ATP-competitive CDK inhibitor able to cross the blood brain barrier for use in the treatment of malignant glioma and, in particular, of glioblastoma. The compound can be administered together with one or more agents selected from the group consisting of cytotoxic or cytostatic agents and ionizing radiation.
摘要翻译: 本发明提供了能够跨越血脑屏障用于治疗恶性胶质瘤,特别是胶质母细胞瘤的低分子量ATP竞争性CDK抑制剂。 化合物可以与一种或多种选自细胞毒性或细胞抑制剂和电离辐射剂的药物一起施用。
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公开(公告)号:US20110190311A1
公开(公告)日:2011-08-04
申请号:US13055533
申请日:2009-07-28
IPC分类号: C07D471/04 , A61K31/496 , A61P35/00
CPC分类号: A61K31/519 , A61K31/4188 , A61K45/06 , A61K2300/00
摘要: The invention provides a low molecular weight ATP-competitive CDK inhibitor able to cross the blood brain barrier for use in the treatment of malignant glioma and, in particular, of glioblastoma. The compound can be administered together with one or more agents selected from the group consisting of cytotoxic or cytostatic agents and ionizing radiation.
摘要翻译: 本发明提供了能够跨越血脑屏障用于治疗恶性胶质瘤,特别是胶质母细胞瘤的低分子量ATP竞争性CDK抑制剂。 化合物可以与一种或多种选自细胞毒性或细胞抑制剂和电离辐射剂的药物一起施用。
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公开(公告)号:US07670133B2
公开(公告)日:2010-03-02
申请号:US10541466
申请日:2003-12-30
IPC分类号: B29C51/00
CPC分类号: B29C51/267 , B29C35/16 , B29C51/10 , B29C51/12 , B29C51/14 , B29C51/20 , B29C51/262 , B29C51/38 , B29C51/421 , B29C51/425 , B29C51/428 , B29C51/46 , B29C65/028 , B29C66/1122 , B29C66/54 , B29C66/71 , B29C66/72341 , B29C66/73921 , B29C66/832 , B29C66/8322 , B29C2791/006 , B29K2995/0063 , B29K2995/0067 , B29K2995/0069 , B29L2031/30 , B29L2031/7172 , B29K2023/00 , B29K2023/086
摘要: A method and a plant for twin-sheet thermoforming of fuel tanks; first and second sheets (SA, SB) of thermoformable plastic material, are separately fed along respective processing lines (10A, 10B). The sheets (SA, SB) are heated and gripped along their peripheral edges by a pneumatically actuate suction and vacuum holding device (15A, 15B), for supporting the heated sheets (SA, SB) in a substantially flat condition while they are moved towards a respective thermoforming station (16A, 16B). Both the molds (17A, 17B) are disposed side by side with their open cavity facing upwards. After thermoforming of the plastic sheets (SA, SB), one of the molds (17B) is turned upside down onto the other mold (17A), to overlap and weld superimposed sealing areas of the two thermoformed shells (GA, GB). Cooling of the molds and thermoformed tank may be performed on a side of the processing lines (10A, 10B).
摘要翻译: 燃料箱双板热成型的方法和装置; 可热成形塑料的第一和第二片(SA,SB)分别沿着各自的处理线(10A,10B)进给。 片材(SA,SB)通过气动致动的抽吸和真空保持装置(15A,15B)沿着它们的周边边缘被加热和夹持,用于在基本上平坦的状态下将加热的片材(SA,SB)支撑在它们被移动到 相应的热成型工位(16A,16B)。 两个模具(17A,17B)并排设置,其开口腔朝上。 在塑料片(SA,SB)热成型之后,将其中一个模具(17B)上下翻转到另一个模具(17A)上,以重叠和焊接两个热成型壳体(GA,GB)的叠加的密封区域。 可以在处理线(10A,10B)的一侧进行模具和热成型罐的冷却。
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