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    Crystalline forms of ibandronic acid and processes for the preparation thereof
    9.
    发明申请
    Crystalline forms of ibandronic acid and processes for the preparation thereof 审中-公开
    伊班膦酸的结晶形式及其制备方法

    公开(公告)号：US20090099390A1

    公开(公告)日：2009-04-16

    申请号：US12284811

    申请日：2008-09-24

    申请人： Claude Singer ,  Sharon W. Avhar-Maydan ,  Tamas Koltai ,  Amir Gold

    发明人： Claude Singer ,  Sharon W. Avhar-Maydan ,  Tamas Koltai ,  Amir Gold

    IPC分类号： C07F9/38

    CPC分类号： C07F9/386 ,  C07F9/3873

    摘要： A crystalline ibandronic acid characterized by data selected from the group consisting of at least one of a powder x-ray diffraction pattern having peaks at about 4.1, 12.3 and 13.4±0.2 degrees two-theta and at least two more peaks selected from the group consisting of: 8.2, 11.3, 16.2 and 16.9 and 20.8±0.2 degrees two-theta, and by a powder X-ray diffraction pattern depicted in FIG. 1 is provided. Also provided is a crystalline ibandronic acid characterized by data selected from the group consisting of at least one of a powder x-ray diffraction pattern having peaks at about peaks at about 5.2, 11.7, and 18.7±0.2 degrees two-theta and at least two more peaks selected from the group consisting of: 5.8, 10.1, 12.0, 17.1, and 20.0±0.2 degrees two-theta and a powder X-ray diffraction pattern as depicted in FIG. 2. Methods of preparing the crystalline forms are also provided.

    摘要翻译： 一种结晶伊班膦酸，其特征在于选自以下的数据：至少一种粉末X射线衍射图，其具有在约4.1,12.3和13.4±0.2度2-θ以及至少两个以上的峰，所述峰选自 ：8.2,11.3,16.2和16.9和20.8±0.2度2-θ，以及图1中所示的粉末X射线衍射图。 1。 还提供了结晶伊班膦酸，其特征在于选自以下的数据：粉末x射线衍射图中的至少一种，其峰值在约5.2,11.7和18.7±0.2度2θ和至少两个 选自由5.8，10.1，12.0,17.1和20.0±0.2度2-θ组成的组的更多峰和如图1所示的粉末X射线衍射图。 还提供了制备结晶形式的方法。