公开(公告)号：US11679117B2

公开(公告)日：2023-06-20

申请号：US17729427

申请日：2022-04-26

申请人： Marinus Pharmaceuticals, Inc.

发明人： David Czekai ,  Maciej Gasior ,  Lorianne Masuoka ,  Julia Tsai ,  Joseph Hulihan ,  Alex Aimetti

IPC分类号： A61K31/573 ,  A61P25/08 ,  A61K9/00

CPC分类号： A61K31/573 ,  A61K9/0019 ,  A61P25/08

摘要： This invention relates to methods for treating status epilepticus by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid. The method provides SE suppression and continued suppression of SE.

公开(公告)号：US20240245709A1

公开(公告)日：2024-07-25

申请号：US18625718

申请日：2024-04-03

申请人： MARINUS PHARMACEUTICALS, INC.

发明人： Henrikas VAITKEVICIUS ,  Maciej Gasior ,  Joseph Hulihan

IPC分类号： A61K31/57 ,  A61K9/00 ,  A61K31/724

CPC分类号： A61K31/57 ,  A61K9/0019 ,  A61K31/724

摘要： This invention relates to methods for treating established status epilepticus (ESE) by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid. The method provides ESE suppression and continued suppression of ESE.

公开(公告)号：US11110100B2

公开(公告)日：2021-09-07

申请号：US17186569

申请日：2021-02-26

申请人： Marinus Pharmaceuticals, Inc.

发明人： David Czekai ,  Maciej Gasior ,  Lorianne Masuoka ,  Julia Tsai ,  Joseph Hulihan ,  Alex Aimetti

IPC分类号： A61K31/573 ,  A61P25/08 ,  A61K9/00

摘要： This invention relates to methods for treating status epilepticus by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid. The method provides SE suppression and continued suppression of SE.