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1.发明申请公开(公告)号：US20120028897A1
公开(公告)日：2012-02-02
申请号：US13132262
申请日：2009-12-01
申请人： Mark G. Currie , Michael F. Goy , Marco M. Kessler , Nicholas G. Moss , Robert M. Solinga , Daniel P. Zimmer
发明人： Mark G. Currie , Michael F. Goy , Marco M. Kessler , Nicholas G. Moss , Robert M. Solinga , Daniel P. Zimmer
摘要： Methods of treating fluid retention disorders with the B isomers of guanylin family peptides are described herein. UgnB, when compared to the A isomer (UgnA), exhibits a conventional sigmoidal dose-response relationship in its natriuetic activity. Further, unlike UgnA, UgnB only weakly activates the GC-C receptor. Compositions comprising purified, or mixtures containing B isomers of guanylin family peptides are described herein are therefore useful for the treatment of fluid retention disorders.
摘要翻译： 本文描述了用鸟苷蛋白家族肽的B异构体治疗流体保留障碍的方法。 当与A异构体（UgnA）相比时，UgnB在其活性中表现出常规的S形剂量 - 反应关系。 此外，与UgnA不同，UgnB仅弱活化GC-C受体。 因此，本文描述了包含纯化的组合物或含有鸟苷蛋白家族肽的B异构体的混合物，因此可用于治疗流体保留障碍。
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公开(公告)号：US20140342996A1
公开(公告)日：2014-11-20
申请号：US14124282
申请日：2012-06-08
摘要： The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.
摘要翻译： 本发明提供了治疗较低胃肠道疾病（包括肠易激综合征和便秘）的药物组合物和方法。
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3.发明申请SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS 审中-公开用于治疗脂肪相关疾病的可溶性葡萄糖环化酶（SGC）调节剂公开(公告)号：US20100144864A1
公开(公告)日：2010-06-10
申请号：US12594744
申请日：2008-04-03
申请人： Mark G. Currie , Daniel P. Zimmer
发明人： Mark G. Currie , Daniel P. Zimmer
CPC分类号： A61K31/34 , A61K31/04 , A61K31/165 , A61K31/192 , A61K31/21 , A61K31/40 , A61K31/407 , A61K31/5377 , A61K31/541
摘要： Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising one or more sGC modulators alone or in combination with one or more lipid altering agents and/or PDE inhibitors.
摘要翻译： 本文公开了用于治疗或预防与脂质代谢相关的多种病症和病症的新型组合物和方法。 所述方法通常包括向有需要的患者施用治疗有效量的药物组合物，其包含单独一种或多种sGC调节剂或与一种或多种脂质改变剂和/或PDE抑制剂组合。
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公开(公告)号：US20140348942A1
公开(公告)日：2014-11-27
申请号：US14124286
申请日：2012-06-08
摘要： The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention.
摘要翻译： 本发明提供了治疗下消化道疾病的药物组合物和方法，包括炎症性肠病（IBD），憩室炎，结肠癌，炎症性疾病，肥胖，充血性心力衰竭，良性前列腺增生（BPH），疼痛，盐滞留或流体 保留。
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公开(公告)号：US20120088902A1
公开(公告)日：2012-04-12
申请号：US12306788
申请日：2007-06-27
申请人： Mark G. Currie , Daniel P. Zimmer
发明人： Mark G. Currie , Daniel P. Zimmer
CPC分类号： C07K14/4705 , A61K38/00
摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders and disorders and conditions associated with excess fluid and/or salt retention as well as other conditions and disorders are described. The compositions feature polypeptides that activate the guanylate cyclase C (GC-C) receptor.
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公开(公告)号：US20140179607A9
公开(公告)日：2014-06-26
申请号：US13508843
申请日：2010-11-09
CPC分类号： A61K38/10 , A61K38/00 , A61K45/06 , C07K7/08 , C07K14/4702
摘要： The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.
摘要翻译： 本发明提供可用于治疗胃肠道疾病的肽。 本发明还提供治疗胃肠疾病的组合物和方法以及用于实现其的药物组合物。 在一些实施方案中，这些药物组合物包括口服剂型。
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公开(公告)号：US08507447B2
公开(公告)日：2013-08-13
申请号：US12942887
申请日：2010-11-09
IPC分类号： A61K38/10
CPC分类号： A61K38/10 , A61K38/00 , A61K45/06 , C07K7/08 , C07K14/4702
摘要： The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.
摘要翻译： 本发明提供可用于治疗胃肠道疾病的肽。 本发明还提供治疗胃肠疾病的组合物和方法以及用于实现其的药物组合物。 在一些实施方案中，这些药物组合物包括口服剂型。
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公开(公告)号：US20120283411A9
公开(公告)日：2012-11-08
申请号：US12306788
申请日：2007-06-27
申请人： Mark G. Currie , Daniel P. Zimmer
发明人： Mark G. Currie , Daniel P. Zimmer
CPC分类号： C07K14/4705 , A61K38/00
摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders and disorders and conditions associated with excess fluid and/or salt retention as well as other conditions and disorders are described. The compositions feature polypeptides that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译： 用于治疗IBS和其他胃肠道疾病和病症的组合物和相关方法（例如，胃肠动力障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括 功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻），与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和与神经性疾病相关的便秘 描述了与过量流体和/或盐保留以及其它条件和病症相关的疾病和病症。组合物特征在于激活鸟苷酸环化酶C（GC-C）受体的多肽。
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9.发明申请Compositions and Methods for Treating Disorders Associated with Salt or Fluid Retention 审中-公开治疗与盐或液体保留有关的疾病的组合物和方法公开(公告)号：US20120040025A9
公开(公告)日：2012-02-16
申请号：US12598792
申请日：2008-04-23
申请人： Mark G. Currie , Daniel P. Zimmer
发明人： Mark G. Currie , Daniel P. Zimmer
CPC分类号： A61K31/675 , A61K31/4706 , A61K38/04 , A61K38/10 , A61K38/16 , A61K45/06 , Y02A50/414 , A61K2300/00
摘要： Methods for reducing the risk of or treating a disorder associated with fluid and/or salt retention in a patient are described. The methods include administering to the patient an agent selected from: a) an agent that reduces sodium absorption in the intestine; b) an agent that increases anion secretion in the intestine; or c) an agent that both reduces sodium absorption in the intestine and increases anion secretion in the intestine.
摘要翻译： 描述了减少与患者中的流体和/或盐保留相关的病症的风险或治疗疾病的方法。 所述方法包括向患者施用选自以下的试剂：a）降低肠中钠吸收的试剂; b）增加肠中阴离子分泌的药剂; 或c）既减少肠中钠吸收并增加肠内阴离子分泌的试剂。
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10.发明申请Compositions and Methods for Treating Disorders Associated with Salt or Fluid Retention 审中-公开治疗与盐或液体保留有关的疾病的组合物和方法公开(公告)号：US20100215779A1
公开(公告)日：2010-08-26
申请号：US12598792
申请日：2008-04-23
申请人： Mark G. Currie , Daniel P. Zimmer
发明人： Mark G. Currie , Daniel P. Zimmer
CPC分类号： A61K31/675 , A61K31/4706 , A61K38/04 , A61K38/10 , A61K38/16 , A61K45/06 , Y02A50/414 , A61K2300/00
摘要： Methods for reducing the risk of or treating a disorder associated with fluid and/or salt retention in a patient are described. The methods include administering to the patient an agent selected from: a) an agent that reduces sodium absorption in the intestine; b) an agent that increases anion secretion in the intestine; or c) an agent that both reduces sodium absorption in the intestine and increases anion secretion in the intestine.
摘要翻译： 描述了减少与患者中的流体和/或盐保留相关的病症的风险或治疗疾病的方法。 所述方法包括向患者施用选自以下的试剂：a）降低肠中钠吸收的试剂; b）增加肠中阴离子分泌的药剂; 或c）既减少肠中钠吸收并增加肠内阴离子分泌的试剂。
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