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公开(公告)号：USD564040S1
公开(公告)日：2008-03-11
申请号：US29285303
申请日：2007-03-27
申请人： Mark Kurth , Earle Cramer , Hector Rodriguez , Charles Hartlaub
设计人： Mark Kurth , Earle Cramer , Hector Rodriguez , Charles Hartlaub
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公开(公告)号：USD552223S1
公开(公告)日：2007-10-02
申请号：US29258432
申请日：2006-04-20
申请人： Mark Kurth , Hector Rodriguez , Earle Cramer
设计人： Mark Kurth , Hector Rodriguez , Earle Cramer
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公开(公告)号：USD564039S1
公开(公告)日：2008-03-11
申请号：US29285302
申请日：2007-03-27
申请人： Hector Rodriguez , Earle Cramer , Mark Kurth
设计人： Hector Rodriguez , Earle Cramer , Mark Kurth
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公开(公告)号：USD564041S1
公开(公告)日：2008-03-11
申请号：US29285276
申请日：2007-03-26
申请人： Hector Rodriguez , Earle Cramer , Mark Kurth , Mark Johnson
设计人： Hector Rodriguez , Earle Cramer , Mark Kurth , Mark Johnson
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公开(公告)号：USD547391S1
公开(公告)日：2007-07-24
申请号：US29260374
申请日：2006-05-23
申请人： Mark Johnson , Hector Rodriguez , Mark Kurth , Earle Cramer
设计人： Mark Johnson , Hector Rodriguez , Mark Kurth , Earle Cramer
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公开(公告)号：USD552721S1
公开(公告)日：2007-10-09
申请号：US29256589
申请日：2006-03-22
申请人： Mark Kurth , Hector Rodriguez , Earle Cramer
设计人： Mark Kurth , Hector Rodriguez , Earle Cramer
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公开(公告)号：USD566200S1
公开(公告)日：2008-04-08
申请号：US29260370
申请日：2006-05-23
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公开(公告)号：USD524699S1
公开(公告)日：2006-07-11
申请号：US29225011
申请日：2005-03-09
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9.发明授权Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis 有权用于治疗和诊断纤维化，肿瘤侵袭，血管生成和转移的方法和组合物公开(公告)号：US08679485B2
公开(公告)日：2014-03-25
申请号：US12185054
申请日：2008-08-01
申请人： Victoria Smith , Scott Ogg , Peter Van Vlasselaer , Vivian E. Barry , Derek Marshall , Alison Kay Holzer , Hector Rodriguez , Miho Oyasu , Scott Alan McCauley , Carlos Aurelio Garcia , Donna Hiroko Tokuoka Biermann
发明人： Victoria Smith , Scott Ogg , Peter Van Vlasselaer , Vivian E. Barry , Derek Marshall , Alison Kay Holzer , Hector Rodriguez , Miho Oyasu , Scott Alan McCauley , Carlos Aurelio Garcia , Donna Hiroko Tokuoka Biermann
IPC分类号： A61K39/395
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12Q1/6886 , G01N33/57423 , G01N33/57438 , G01N33/57484 , G01N2333/90633
摘要： The present disclosure provides methodology and compositions for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of LOX or LOXL, or a synergistic combination thereof combined with other therapeutic agents. Methods and compositions for diagnosing or monitoring various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, are also provided. Also provided herein are methods and related compositions, medical devices, systems and kits for preventing or treating various diseases and conditions associated with fibrosis with compositions comprising inhibitors of LOX or LOXL.
摘要翻译： 本公开提供了通过使用加工形式的赖氨酰氧化酶或赖氨酰氧化酶样蛋白的抑制剂，LOX或LOXL的抑制剂或协同作用的预防和治疗与异常细胞增殖，血管生成和纤维化相关的各种疾病的方法和组合物 其组合与其它治疗剂组合。 还提供了用于诊断或监测与异常细胞增殖，血管生成和纤维化相关的各种疾病的方法和组合物。 本文还提供了用包含LOX或LOXL抑制剂的组合物预防或治疗与纤维化相关的各种疾病和病症的方法和相关组合物，医疗装置，系统和试剂盒。
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公开(公告)号：US20130203602A1
公开(公告)日：2013-08-08
申请号：US13583890
申请日：2011-03-11
申请人： Anders Riisager , Rasmus Fehrmann , Hector Rodriguez , Katharina Bica , Robin D. Rogers , Daniel T. Daly , Gabriela Gurau
发明人： Anders Riisager , Rasmus Fehrmann , Hector Rodriguez , Katharina Bica , Robin D. Rogers , Daniel T. Daly , Gabriela Gurau
摘要： The present invention relates to biologically active compounds, particularly liquid compounds, which are immobilized on a solid carrier material, particularly on mesoporous silica. The compounds are non-covalently supported on the solid carrier material thereby forming stable, easily handled solids which have the further advantage that the adsorbed biologically active compounds have improved thermal stability compared with the non-adsorbed compounds, and that they are released rapidly and completely from the carrier material when placed in an aqueous environment.
摘要翻译： 本发明涉及固定在固体载体材料上，特别是介孔二氧化硅上的生物活性化合物，特别是液体化合物。 这些化合物非固定地负载在固体载体材料上，从而形成稳定的，容易处理的固体，其具有进一步的优点，即吸附的生物活性化合物与非吸附化合物相比具有改善的热稳定性，并且它们被快速且完全地释放 当载体材料放置在水性环境中时。
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