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8 条记录 (耗时 0.034 秒)

    Depression gene
    3.
    发明授权
    Depression gene 失效
    抑郁基因

    公开(公告)号：US07572905B1

    公开(公告)日：2009-08-11

    申请号：US11877474

    申请日：2007-10-23

    申请人： Donna Shattuck ,  Deanna Russell ,  Victor Abkevich ,  Chris Neff

    发明人： Donna Shattuck ,  Deanna Russell ,  Victor Abkevich ,  Chris Neff

    IPC分类号： C07H21/04

    CPC分类号： C07K14/4747

    摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depression. More specifically, the invention relates to germline mutations in the APAF1 gene and their use in the diagnosis of predisposition to depression. The invention also relates to the prophylaxis and/or therapy of depression associated with a mutation in the APAF1 gene. The invention further relates to the screening of drugs for depression therapy. Finally, the invention relates to the screening of the APAF1 gene for mutations/alterations, which are useful for diagnosing the predisposition to depression.

    摘要翻译： 本发明一般涉及人类遗传学领域。 具体地，本发明涉及用于分离和检测人类抑郁症易感基因，特别是凋亡蛋白酶活化因子1（APAF1）基因的一些突变等位基因导致抑郁症易感性的方法和材料。 更具体地说，本发明涉及APAF1基因中的种系突变及其在抑郁倾向诊断中的应用。 本发明还涉及与APAF1基因突变相关的抑郁症的预防和/或治疗。 本发明进一步涉及抑郁症药物的筛选。 最后，本发明涉及用于突变/改变的APAF1基因的筛选，其可用于诊断抑郁倾向。

    Depression gene
    4.
    发明授权
    Depression gene 失效

    公开(公告)号：US07544475B2

    公开(公告)日：2009-06-09

    申请号：US11750019

    申请日：2007-05-17

    申请人： Donna Shattuck ,  Deanna Russell ,  Victor Abkevich ,  Chris Neff ,  Lisa Cannon-Albright ,  Nicola Camp

    发明人： Donna Shattuck ,  Deanna Russell ,  Victor Abkevich ,  Chris Neff ,  Lisa Cannon-Albright ,  Nicola Camp

    IPC分类号： C12Q1/68

    CPC分类号： C07K14/4747

    摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depression. More specifically, the invention relates to germline mutations in the APAF1 gene and their use in the diagnosis of predisposition to depression. The invention also relates to the prophylaxis and/or therapy of depression associated with a mutation in the APAF1 gene. The invention further relates to the screening of drugs for depression therapy. Finally, the invention relates to the screening of the APAF1 gene for mutations/alterations, which are useful for diagnosing the predisposition to depression.

    Depression gene
    6.
    发明授权
    Depression gene 失效
    抑郁基因

    公开(公告)号：US07410944B1

    公开(公告)日：2008-08-12

    申请号：US11441887

    申请日：2006-05-26

    申请人： Donna Shattuck ,  Deanna Russell ,  Victor Abkevich ,  Chris Neff

    发明人： Donna Shattuck ,  Deanna Russell ,  Victor Abkevich ,  Chris Neff

    IPC分类号： C07K14/00

    CPC分类号： C07K14/4747

    摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depression. More specifically, the invention relates to germline mutations in the APAF1 gene and their use in the diagnosis of predisposition to depression. The invention also relates to the prophylaxis and/or therapy of depression associated with a mutation in the APAF1 gene. The invention further relates to the screening of drugs for depression therapy. Finally, the invention relates to the screening of the APAF1 gene for mutations/alterations, which are useful for diagnosing the predisposition to depression.

    摘要翻译： 本发明一般涉及人类遗传学领域。 具体地，本发明涉及用于分离和检测人类抑郁症易感基因，特别是凋亡蛋白酶活化因子1（APAF1）基因的一些突变等位基因导致抑郁症易感性的方法和材料。 更具体地说，本发明涉及APAF1基因中的种系突变及其在抑郁倾向诊断中的应用。 本发明还涉及与APAF1基因突变相关的抑郁症的预防和/或治疗。 本发明进一步涉及抑郁症药物的筛选。 最后，本发明涉及用于突变/改变的APAF1基因的筛选，其可用于诊断抑郁倾向。

    DEPRESSION GENE
    7.
    发明申请
    DEPRESSION GENE 失效
    拒绝基因

    公开(公告)号：US20080160519A1

    公开(公告)日：2008-07-03

    申请号：US11750019

    申请日：2007-05-17

    申请人： Donna Shattuck ,  Deanna Russell ,  Victor Abkevich ,  Chris Neff ,  Lisa Cannon-Albright ,  Nicola Camp

    发明人： Donna Shattuck ,  Deanna Russell ,  Victor Abkevich ,  Chris Neff ,  Lisa Cannon-Albright ,  Nicola Camp

    IPC分类号： C12Q1/68 ,  G01N33/566 ,  G01N33/68 ,  C12Q1/37 ,  C07K2/00

    CPC分类号： C07K14/4747

    摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depression. More specifically, the invention relates to germline mutations in the APAF1 gene and their use in the diagnosis of predisposition to depression. The invention also relates to the prophylaxis and/or therapy of depression associated with a mutation in the APAF1 gene. The invention further relates to the screening of drugs for depression therapy. Finally, the invention relates to the screening of the APAF1 gene for mutations/alterations, which are useful for diagnosing the predisposition to depression.

    摘要翻译： 本发明一般涉及人类遗传学领域。 具体地，本发明涉及用于分离和检测人类抑郁症易感基因，特别是凋亡蛋白酶激活因子1（APAF1）基因的一些突变等位基因导致抑郁症易感性的方法和材料。 更具体地说，本发明涉及APAF1基因中的种系突变及其在抑郁倾向诊断中的应用。 本发明还涉及与APAF1基因突变相关的抑郁症的预防和/或治疗。 本发明进一步涉及抑郁症药物的筛选。 最后，本发明涉及用于突变/改变的APAF1基因的筛选，其可用于诊断抑郁倾向。

    Depression gene
    8.
    发明授权
    Depression gene 失效

    公开(公告)号：US07052853B1

    公开(公告)日：2006-05-30

    申请号：US10646396

    申请日：2003-08-21

    申请人： Donna Shattuck ,  Deanna Russell ,  Victor Abkevich ,  Chris Neff

    发明人： Donna Shattuck ,  Deanna Russell ,  Victor Abkevich ,  Chris Neff

    IPC分类号： C12N33/53 ,  C07K14/00

    CPC分类号： C07K14/4747

    摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depression. More specifically, the invention relates to germline mutations in the APAF1 gene and their use in the diagnosis of predisposition to depression. The invention also relates to the prophylaxis and/or therapy of depression associated with a mutation in the APAF1 gene. The invention further relates to the screening of drugs for depression therapy. Finally, the invention relates to the screening of the APAF1 gene for mutations/alterations, which are useful for diagnosing the predisposition to depression.