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1.发明申请公开(公告)号：US20100323029A1
公开(公告)日：2010-12-23
申请号：US12817085
申请日：2010-06-16
IPC分类号： A61K38/41 , A61K35/14 , A61K35/16 , A61K35/18 , A61P7/06 , A61P7/08 , A61P7/00 , A61P9/10 , A61P17/02 , A61P9/12
CPC分类号： A61K38/41 , A61K9/0019 , A61K35/14 , A61K35/16 , A61K35/18 , A61K38/42 , A61K45/06 , Y02A50/387
摘要： Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild type neuroglobin. Five-coordinate neuroglobin is also capable of binding and releasing oxygen. Based on these findings, the use of five-coordinate neuroglobin as a blood substitute is described herein. Particularly provided is a method of replacing blood and/or increasing oxygen delivery to tissues in a subject by administering to the subject a therapeutically effective amount of neuroglobin with a stable five-coordinate geometry. In some cases, five-coordinate neuroglobin is administered in combination with another therapeutic agent or composition, such as a second blood replacement product (for example, a hemoglobin-based oxygen carrier), a blood product (such as red blood cells, serum or plasma) or whole blood.
摘要翻译： 这里描述的发现是具有稳定的五坐标几何形状的人类神经球蛋白（H64L）的突变形式将亚硝酸盐比野生型神经球蛋白的亚硝酸盐还原为大约2000倍的一氧化氮。 五配位神经球蛋白也能够结合和释放氧气。 基于这些发现，本文描述了使用五配位神经球蛋白作为血液代用品。 特别提供的是通过向受试者施用具有稳定的五坐标几何形状的治疗有效量的神经球蛋白来替代血液和/或增加对受试者组织的氧输送的方法。 在一些情况下，五配位神经球蛋白与另一种治疗剂或组合物，例如第二种血液替代产品（例如，基于血红蛋白的氧载体），血液制品（例如红细胞，血清或 血浆）或全血。
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公开(公告)号：US09114109B2
公开(公告)日：2015-08-25
申请号：US12817085
申请日：2010-06-16
CPC分类号： A61K38/41 , A61K9/0019 , A61K35/14 , A61K35/16 , A61K35/18 , A61K38/42 , A61K45/06 , Y02A50/387
摘要： Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild type neuroglobin. Five-coordinate neuroglobin is also capable of binding and releasing oxygen. Based on these findings, the use of five-coordinate neuroglobin as a blood substitute is described herein. Particularly provided is a method of replacing blood and/or increasing oxygen delivery to tissues in a subject by administering to the subject a therapeutically effective amount of neuroglobin with a stable five-coordinate geometry. In some cases, five-coordinate neuroglobin is administered in combination with another therapeutic agent or composition, such as a second blood replacement product (for example, a hemoglobin-based oxygen carrier), a blood product (such as red blood cells, serum or plasma) or whole blood.
摘要翻译： 这里描述的发现是具有稳定的五坐标几何形状的人类神经球蛋白（H64L）的突变形式将亚硝酸盐比野生型神经球蛋白的亚硝酸盐还原为大约2000倍的一氧化氮。 五配位神经球蛋白也能够结合和释放氧气。 基于这些发现，本文描述了使用五配位神经球蛋白作为血液代用品。 特别提供的是通过向受试者施用具有稳定的五坐标几何形状的治疗有效量的神经球蛋白来替代血液和/或增加对受试者组织的氧输送的方法。 在一些情况下，五配位神经球蛋白与另一种治疗剂或组合物，例如第二种血液替代产品（例如，基于血红蛋白的氧载体），血液制品（例如红细胞，血清或 血浆）或全血。
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