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    COMPOSITIONS AND METHODS FOR NEURALGENESIS
    5.
    发明申请
    COMPOSITIONS AND METHODS FOR NEURALGENESIS 审中-公开

    公开(公告)号：US20190046583A1

    公开(公告)日：2019-02-14

    申请号：US16077411

    申请日：2017-02-10

    申请人： THE JOHNS HOPKINS UNIVERSITY

    发明人： Fan Pan ,  Duojia Pan ,  Drew M. Pardoll ,  Joseph Barbi ,  Juan Fu

    IPC分类号： A61K35/30 ,  A61K38/41 ,  G01N33/68 ,  G01N33/58 ,  C12N5/074 ,  C12N5/00

    摘要： The present invention relates to novel compositions and methods to produce 3D organ equivalents of the brain (i.e. “mini-brains”). The invention also relates to methods of using human induced pluripotent stem cells, a combination of growth and other soluble factors and gyratory shaking. Cells from healthy or diseased donors or animals can be used to allow testing different genetic backgrounds. The model can be further enhanced by using genetically modified cells, adding micro-glia or their precursors or indicator cells (e.g. with reporter genes or tracers) as well as adding endothelial cells to form a blood-brain-barrier.

    FIVE-COORDINATE NEUROGLOBIN AND USE THEREOF AS A BLOOD SUBSTITUTE
    7.
    发明申请
    FIVE-COORDINATE NEUROGLOBIN AND USE THEREOF AS A BLOOD SUBSTITUTE 审中-公开
    作为血液替代品使用五种协调的神经营养因子及其使用

    公开(公告)号：US20150306183A1

    公开(公告)日：2015-10-29

    申请号：US14795115

    申请日：2015-07-09

    申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Wake Forest University

    发明人： Mark T. Gladwin ,  Daniel B. Kim-Shapiro ,  Mauro Tiso

    IPC分类号： A61K38/41 ,  A61K45/06 ,  A61K9/00

    CPC分类号： A61K38/41 ,  A61K9/0019 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/42 ,  A61K45/06 ,  Y02A50/387

    摘要： Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild type neuroglobin. Five-coordinate neuroglobin is also capable of binding and releasing oxygen. Based on these findings, the use of five-coordinate neuroglobin as a blood substitute is described herein. Particularly provided is a method of replacing blood and/or increasing oxygen delivery to tissues in a subject by administering to the subject a therapeutically effective amount of neuroglobin with a stable five-coordinate geometry. In some cases, five-coordinate neuroglobin is administered in combination with another therapeutic agent or composition, such as a second blood replacement product (for example, a hemoglobin-based oxygen carrier), a blood product (such as red blood cells, serum or plasma) or whole blood.

    摘要翻译： 这里描述的发现是具有稳定的五坐标几何形状的人类神经球蛋白（H64L）的突变形式将亚硝酸盐比野生型神经球蛋白的亚硝酸盐还原为大约2000倍的一氧化氮。 五配位神经球蛋白也能够结合和释放氧气。 基于这些发现，本文描述了使用五配位神经球蛋白作为血液代用品。 特别提供的是通过向受试者施用具有稳定的五坐标几何形状的治疗有效量的神经球蛋白来替代血液和/或增加对受试者组织的氧输送的方法。 在一些情况下，五配位神经球蛋白与另一种治疗剂或组合物，例如第二种血液替代产品（例如，基于血红蛋白的氧载体），血液制品（例如红细胞，血清或 血浆）或全血。

    Stabilized products, process and devices for preparing same
    8.
    发明授权
    Stabilized products, process and devices for preparing same 有权
    稳定的产品，工艺和制备装置

    公开(公告)号：US08013022B2

    公开(公告)日：2011-09-06

    申请号：US11796451

    申请日：2007-04-27

    申请人： Joseph DeAngelo ,  David Needham ,  Carroll Jones

    发明人： Joseph DeAngelo ,  David Needham ,  Carroll Jones

    IPC分类号： B01F3/08 ,  C12M1/00 ,  A61K38/41

    CPC分类号： A61J1/10 ,  A01N1/02 ,  A01N1/0263 ,  A61M1/0209 ,  A61M1/0227 ,  A61M1/0272 ,  Y10S514/832 ,  Y10S514/833 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S516/923 ,  Y10T428/2982

    摘要： Disclosed is a multi-compartment medical device useful in the storage, processing and extended shelf life of perishable products, especially pharmaceutical, food and biological products. Particular biological materials processed according to the present methods are human blood and blood products (RBCs). Also disclosed are processes for preserving food, pharmaceutical and biological products for long-term storage and extended shelf life employing a process that reduces the hydration level of the material to less than native hydration levels of the specific product. The invention further provides stabilized biological products, such as in the form of glassified beads, prepared using a two-phase system according to the described processes that may be rehydrated and prepared for clinical use, and having essentially no loss of biological and/or pharmacological activity.

    摘要翻译： 公开了一种多室医疗装置，其用于易腐食品，特别是制药，食品和生物制品的储存，加工和延长的保存期限。 根据本方法处理的特定生物材料是人血液和血液制品（RBC）。 还公开了用于保存食品，药物和生物产品以用于长期储存和延长保存期限的方法，其使用将材料的水合水平降低至小于特定产品的天然水合水平的方法。 本发明进一步提供了稳定的生物产品，例如以玻璃化珠粒的形式，使用根据所述方法的两相系统制备，所述两相系统可以被再水化并制备用于临床应用，并且基本上不丧失生物和/或药理学 活动。