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1.发明申请COMPOUNDS FOR BINDING TO THE PLATELET SPECIFIC GLYCOPROTEIN IIB/IIIA AND THEIR USE FOR IMAGING OF THROMBI 有权用于与特异性糖蛋白IIB / IIIA结合的化合物及其用于成像THROMBI的用途公开(公告)号：US20140314669A1
公开(公告)日：2014-10-23
申请号：US14239065
申请日：2012-08-17
CPC分类号： A61K51/088 , A61J1/06 , A61K49/0433 , C07D211/60 , C07D401/04 , C07D401/06 , C07D401/14 , C07K5/06
摘要： The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.
摘要翻译： 本发明涉及新的含氟化合物，其制备方法，合成中间体，它们作为诊断剂的用途，特别是用于血栓成像。 本发明涉及正电子发射断层摄影（PET）剂和相关的前体试剂，以及用于在哺乳动物体内产生用于血栓成像的放射性物质的方法。 更具体地，本发明涉及用于血栓成像的小的非肽，高亲和力，特异性结合的糖蛋白11b / IIIa拮抗剂。
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2.发明授权Compounds for binding to the platelet specific glycoprotein IIB/IIIA and their use for imaging of thrombi 有权用于结合血小板特异性糖蛋白IIB / IIIA的化合物及其用于血栓成像的用途公开(公告)号：US09345793B2
公开(公告)日：2016-05-24
申请号：US14239065
申请日：2012-08-17
IPC分类号： A61K51/08 , C07D401/04 , C07D401/06 , C07K5/06
CPC分类号： A61K51/088 , A61J1/06 , A61K49/0433 , C07D211/60 , C07D401/04 , C07D401/06 , C07D401/14 , C07K5/06
摘要： The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.
摘要翻译： 本发明涉及新的含氟化合物，其制备方法，合成中间体，它们作为诊断剂的用途，特别是用于血栓成像。 本发明涉及正电子发射断层摄影（PET）剂和相关的前体试剂，以及用于在哺乳动物体内产生用于血栓成像的放射性物质的方法。 更具体地，本发明涉及用于血栓成像的小的非肽，高亲和力，特异性结合的糖蛋白11b / IIIa拮抗剂。
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