公开(公告)号：US06013495A

公开(公告)日：2000-01-11

申请号：US951200

申请日：1997-10-14

申请人： Martin A. Schwartz ,  Jere E. Meredith, Jr. ,  Yoshikazu Takada ,  Lucia Languino

发明人： Martin A. Schwartz ,  Jere E. Meredith, Jr. ,  Yoshikazu Takada ,  Lucia Languino

IPC分类号： A61K38/00 ,  C07K14/705 ,  C12N1/38 ,  C07K7/08 ,  C07K14/435 ,  C12N13/00

CPC分类号： C07K14/7055 ,  A61K38/00

摘要： The present invention provides a method for inhibiting cell proliferation in a cell comprising contacting the cell with a nucleic acid sequence or a polypeptide having essentially the sequence of the .beta..sub.1C integrin. Also included in the invention are peptides consisting of amino acid residues which are the size of or fewer than the sequence of the cytoplasmic domain of the .beta..sub.1C integrin consisting essentially of the amino acid sequence of SEQ ID NO:1 and SEQ ID NO:2, and functional fragments thereof which are useful for inhibiting cellular proliferation. Peptides, polynucleotides, and antibodies immunoreactive with the peptides, and methods of use for inhibiting cell growth are also provided.

摘要翻译： 本发明提供了抑制细胞中细胞增殖的方法，包括使细胞与基本上具有β1C整联蛋白序列的核酸序列或多肽接触。 本发明还包括由基本上由SEQ ID NO：1和SEQ ID NO：2的氨基酸序列组成的β1C整联蛋白的大小或小于其序列的氨基酸残基的肽 及其功能片段，其可用于抑制细胞增殖。 还提供了肽，多核苷酸和与肽免疫反应的抗体，以及用于抑制细胞生长的方法。