公开(公告)号：US20110178099A1

公开(公告)日：2011-07-21

申请号：US12995882

申请日：2009-06-04

申请人： Martin Friedrich Stefanic ,  Frank Hilberg ,  Rolf Kaiser ,  David Shapiro

发明人： Martin Friedrich Stefanic ,  Frank Hilberg ,  Rolf Kaiser ,  David Shapiro

IPC分类号： A61K31/519 ,  A61P3/10 ,  A61P35/00 ,  A61P17/06 ,  A61P29/00 ,  A61P37/06 ,  A61P27/02

CPC分类号： A61K31/519 ,  A61K9/4858 ,  A61K31/496 ,  A61N5/10 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, which involve migration or apoptosis of myeloma cells, which involve angiogenesis or which involve fibrosis. The invention also relates to a method for the treatment of said diseases, comprising simultaneous, separate or sequential administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

摘要翻译： 本发明涉及可用于治疗涉及涉及血管生成或涉及纤维化的骨髓瘤细胞迁移或凋亡的细胞增殖的疾病的药物组合。 本发明还涉及一种用于治疗所述疾病的方法，包括以提供添加剂和协同效应的比例同时，分别或连续施用有效量的特定活性化合物和/或与放射治疗共同治疗，以及 将这些特定化合物和/或放射疗法的组合使用用于制造相应的药物组合制剂。